Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Su Yun Wang"'
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract Interferons (IFNs) activate JAK‐STAT pathways to induce downstream effector genes for host defense against invaded pathogens and tumors. Here both type I (β) and II (γ) IFNs are shown that can activate the transcription factor IRF3 in pa
Externí odkaz:
https://doaj.org/article/591c80fb4629487aa7be2ccc679b0658
Autor:
Wei-Wei Luo, Zhen Tong, Pan Cao, Fu-Bing Wang, Ying Liu, Zhou-Qin Zheng, Su-Yun Wang, Shu Li, Yan-Yi Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The transcription factor IRF8 has been shown to regulate monocyte differentiation via its DNA-binding activity. Here authors show that IRF8 is also involved in cytosolic DNA sensing via its phosphorylation-dependent association to the adaptor protein
Externí odkaz:
https://doaj.org/article/2f7cce334ca742d9bbb81e7290a22a5d
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract The newly emerging coronavirus SARS-CoV-2 causes severe lung disease and substantial mortality. How the virus evades host defense for efficient replication is not fully understood. In this report, we found that the SARS-CoV-2 nucleocapsid pr
Externí odkaz:
https://doaj.org/article/632c797bc210429ea21d9b702364a008
Autor:
Ping Jiang, Jie Li, Hong-Yan Li, Bin Zhang, Yao-Xian Yue, Su-Yun Wang, Xi-Cun Zi, Shuang-Shuang Liu, Yi-Fan Li, Li-Dong Jiao, Hai-Feng Li
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
IntroductionMinimal manifestation (MM) or better was recommended as the treatment goal for myasthenia gravis (MG). The sustainability of this status has not been described quantitatively in patients who had attained or are close to it.MethodsPatients
Externí odkaz:
https://doaj.org/article/2d29393dd68740f6bf671426ac9cbe63
Publikováno v:
Cell Insight, Vol 1, Iss 2, Pp 100014- (2022)
After herpes simplex virus type 1 (HSV-1) infection, the cytosolic sensor cyclic GMP-AMP synthase (cGAS) recognizes DNA and catalyzes synthesis of the second messenger 2′3′-cGAMP. cGAMP binds to the ER-localized adaptor protein MITA (also known a
Externí odkaz:
https://doaj.org/article/fcb8742a208d4c82becae0bdf1e0a522
Publikováno v:
Cell Insight, Vol 1, Iss 1, Pp 100002- (2022)
Bone homeostasis is maintained through continuous remodeling by osteoclast-driven bone resorption and osteoblast-mediated bone formation. Osteoclasts are multinucleated giant cells (MNCs) differentiated from myeloid progenitors of the monocytic linea
Externí odkaz:
https://doaj.org/article/410390bb58914a0db43a302b1b799cf7
Autor:
Yong Ran, Dan Li, Mei-Guang Xiong, Hua-Nan Liu, Tao Feng, Zheng-Wang Shi, Yu-Hui Li, Huang-Ning Wu, Su-Yun Wang, Hai-Xue Zheng, Yan-Yi Wang
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010270 (2022)
ASFV is a large DNA virus that is highly pathogenic in domestic pigs. How this virus is sensed by the innate immune system as well as why it is so virulent remains enigmatic. In this study, we show that the ASFV genome contains AT-rich regions that a
Externí odkaz:
https://doaj.org/article/71cf65a7f51d4c229f77761f2a67e503
Autor:
Hong-Xia Zhang, Zhi-Sheng Xu, Hen Lin, Mi Li, Tian Xia, Kaisa Cui, Su-Yun Wang, Youjun Li, Hong-Bing Shu, Yan-Yi Wang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Aberrant and persistent activation of the transcription factor STAT3 has been found in various types of cancers. Here the authors identify TRIM27 as a positive regulator of IL-6-induced STAT3 activation through the formation of JAK1-STAT3 complex, th
Externí odkaz:
https://doaj.org/article/3c2d0b0fc6204a1b837bc243ca4ab438
Autor:
Shuai‐bing Liu, Xia Yao, Jun Tao, Jian‐jun Yang, Ying‐ying Zhao, Dong‐wei Liu, Su‐yun Wang, Su‐ke Sun, Xu Wang, Pang‐ke Yan, Nan Wu, Xiao Liu, Xiao‐jian Zhang, Xin Tian, Zhang‐suo Liu
Publikováno v:
British Journal of Clinical Pharmacology. 89:1139-1151
The aim of this study was to develop a population pharmacokinetic (PK) model to simultaneously describe both total and unbound concentrations of ciprofol and its major glucuronide metabolite, M4, and to link it to the population pharmacodynamics (PD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a4a67a8a3e0316214aff55db0f4ac1
https://doi.org/10.1111/bcp.15561
https://doi.org/10.1111/bcp.15561
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007691 (2019)
Cyclic GMP-AMP synthase (cGAS) senses viral DNA in the cytosol and then catalyzes synthesis of the second messenger cGAMP, which activates the ER-localized adaptor protein Mediator of IRF3 Activator (MITA) to initiate innate antiviral response. Human
Externí odkaz:
https://doaj.org/article/65ce37c2e1a147088143dc8d2dae55b8