Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors

Autor: Anne W. J. Martens, Inga Kavazović, Mia Krapić, Su Min Pack, Ramon Arens, Aldo Jongejan, Perry D. Moerland, Eric Eldering, Gerritje J. W. van der Windt, Felix M. Wensveen, Fleur S. Peters, Arnon P. Kater

Publikováno v: Leukemia, 1-11. Nature Publishing Group
STARTPAGE=1;ENDPAGE=11;ISSN=0887-6924;TITLE=Leukemia
Leukemia, 37, 606-616. SPRINGERNATURE
Leukemia
Volume 37

T-cell dysregulation in chronic lymphocytic leukemia (CLL) associates with low response rates to autologous T cell-based therapies. How CLL affects antigen-specific T-cell responses remains largely unknown. We investigated (epi)genetic and functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4913b98a4d25cb7dce2df04195881459
https://doi.org/10.1038/s41375-023-01817-z

SARS-CoV-2-Specific Vaccine Candidates; the Contribution of Structural Vaccinology

Autor: Su Min Pack, Peter J. Peters

Publikováno v: Vaccines. 10(2)

SARS-CoV-2 vaccine production has taken us by storm. We aim to fill in the history of concepts and the work of pioneers and provide a framework of strategies employing structural vaccinology. Cryo-electron microscopy became crucial in providing three

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b182585c9a9dbc92b55af26b71919ff8
https://pubmed.ncbi.nlm.nih.gov/35214693