Sildenafil Attenuates Inflammation and Oxidative Stress in Pelvic Ganglia Neurons after Bilateral Cavernosal Nerve Damage

Autor: Richard A. Gutierrez, Leah A. Garcia, Monica G. Ferrini, María Díaz Sánchez, Su M Hlaing, Istvan Kovanecz, Jorge N. Artaza

Publikováno v: International Journal of Molecular Sciences, Vol 15, Iss 10, Pp 17204-17220 (2014)
International Journal of Molecular Sciences
Volume 15
Issue 10
Pages 17204-17220

Erectile dysfunction is a common complication for patients undergoing surgeries for prostate, bladder, and colorectal cancers, due to damage of the nerves associated with the major pelvic ganglia (MPG). Functional re-innervation of target organs depe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf1388ec40da4475dbae5ca0387ff8d
http://www.mdpi.com/1422-0067/15/10/17204

Sildenafil Promotes Smooth Muscle Preservation and Ameliorates Fibrosis Through Modulation of Extracellular Matrix and Tissue Growth Factor Gene Expression After Bilateral Cavernosal Nerve Resection in the Rat

Autor: Jacob Rajfer, Fara Sirad, Su M Hlaing, Istvan Kovanecz, Monica G. Ferrini, Jorge N. Artaza, Leah A. Garcia

Publikováno v: The Journal of Sexual Medicine. 8:1048-1060

Introduction It has been shown that phosphodiesterase type 5 (PDE5) inhibitors preserve smooth muscle (SM) content and ameliorate the fibrotic degeneration normally seen in the corpora cavernosa after bilateral cavernosal nerve resection (BCNR). Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fe5f73e3c79238c4314cf24304ff62
https://doi.org/10.1111/j.1743-6109.2010.02195.x

Treatment with a combination of ginger, L-citrulline, muira puama and Paullinia cupana can reverse the progression of corporal smooth muscle loss, fibrosis and veno-occlusive dysfunction in the aging rat

Autor: Su M Hlaing, Andre Chan, Monica G. Ferrini, Jorge N. Artaza

Publikováno v: Andrology : open access. 4(1)

Aims: Aging associated erectile dysfunction is characterized within the corpora by a progressive apoptosis of the smooth muscle cells and their replacement by collagen. Nitric oxide from iNOS has been shown to inhibit these histological changes in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db90a7d6e564ed2b56174d3865d3784
https://pubmed.ncbi.nlm.nih.gov/26405615