Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Su Er W Huskey"'
Autor:
Diego Albrecht, Priya Chandra, Su-Er W Huskey, Timothy Bedman, Helen Gu, Yancy Du, Lai Wang, Heidi J. Einolf, Jimmy Flarakos, Qusai Al-Share, Pierre Jordaan, James B. Mangold
Publikováno v:
Xenobiotica. 46:986-1000
1. Sacubitril/valsartan (LCZ696) is an angiotensin receptor neprilysin inhibitor (ARNI) providing simultaneous inhibition of neprilysin (neutral endopeptidase 24.11; NEP) and blockade of the angiotensin II type-1 (AT1) receptor. 2. Following oral adm
Autor:
Alexandra Vargas, Oliver Simon, Matthias Kittelmann, Melissa M. Lin, Chun-qi Zhu, Hongmei Li, Su-Er W. Huskey, Helen Gu, Sarah Favara, Handan He, Jin Zhang, Ry R. Forseth, Lai Wang, Alexandre Luneau, Heidi J. Einolf, Fabian K. Eggimann, James B. Mangold
Publikováno v:
Drug Metabolism and Disposition. 44:653-664
KAE609 [(1'R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyridol[3,4-b]indol]-2-one] is a potent, fast-acting, schizonticidal agent being developed for the treatment of malaria. After oral dosing of KAE609 to rats
Publikováno v:
Bioanalysis. 6:617-628
Background: A tiered approach to drug metabolite measurement and identification is often used industry wide to fulfill regulatory requirements specified in recent US FDA and European Medicines Agency guidance. Although this strategy is structured in
Autor:
Ry R Forseth, Alexandre Catoire, Tapan Ray, Jin Zhang, Handan He, James B. Mangold, Su-Er W Huskey, Zhigang Jian, Hongmei Li, Jimmy Flarakos
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 44(10)
Identification of polar metabolites of drug candidates during development is often challenging. Several prominent polar metabolites of 2-amino-1-(2-(4-fluorophenyl)-3-((4-fluorophenyl)amino)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)etha
Autor:
Thomas E. Bradstreet, Anup K. Majumdar, John Busillo, Kala-Jyoti Viswanathan Aiyer, Trisha Fosbinder, Thomas Marbury, Lisa Hickey, Arthur J. Bergman, Kevin J. Petty, Su-Er W. Huskey, Suzanne K. Swan, M.L. Constanzer
Publikováno v:
Clinical Pharmacokinetics. 44:637-647
Background: The neurokinin NK1-receptor antagonist aprepitant has demonstrated efficacy in preventing highly emetogenic chemotherapy-induced nausea and vomiting. Objective: The objective of the present study was to investigate the effects of impaired
Autor:
Su-Er W. Huskey, Ray Bakhtiar, Deborah J. Newton, David C. Evans, Ping Lu, Regina W. Wang, Rosa I. Sanchez, Shuet-Hing Lee Chiu
Publikováno v:
Drug Metabolism and Disposition. 32:1287-1292
The contribution of human cytochrome P450 (P450) isoforms to the metabolism of aprepitant in humans was investigated using recombinant P450s and inhibition studies. In addition, aprepitant was evaluated as an inhibitor of human P450s. Metabolism of a
Autor:
Edward J. Carlini, Xudong Dai, Yudong D. He, Su-er W. Huskey, Roger G. Ulrich, Bonnie Wang, Dylan P. Hartley, David C. Evans, Raymond Evers, Thomas H. Rushmore
Publikováno v:
Molecular Pharmacology. 65:1159-1171
Ligand-mediated activation of the pregnane X receptor (PXR, NR1I2) is postulated to affect both hepatic and intestinal gene expression, because of the presence of this nuclear receptor in these important drug metabolizing organs; as such, activation
Autor:
Zhen Wang, Ronald B. Franklin, Paul E. Finke, Thomas A. Baillie, John R. Strauss, Su Er W Huskey, Shuet Hing L Chiu, William P. Feeney, Brian Dean, Bonnie Wang, Cornelis E. C. A. Hop, George A. Doss, Reza Anari, Minghua Zhang, Robichaud Albert Jean, P Cunningham
Publikováno v:
Drug Metabolism and Disposition. 32:246-258
The absorption, metabolism, and excretion of [14C]aprepitant, a potent and selective human substance P receptor antagonist for the treatment of chemotherapy-induced nausea and vomiting, was evaluated in rats and dogs. Aprepitant was metabolized exten
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 309:156-164
Ethinylestradiol (EE) is one of the key constituents of oral contraceptives. Major metabolites of EE in humans are the glucuronide and sulfate conjugates, EE-3-O-glucuronide (EE-G) and EE-3-O-sulfate (EE-S). In the present study, transport of EE-G an
Publikováno v:
Analytical Chemistry. 74:4136-4144
The extensive metabolism and administration of low doses of ethinylestradiol (EE) in preclinical animal species necessitates a sensitive analytical method to quantify the drug at low picogram-per-milliliter concentrations in biological matrixes. A hi