Zobrazeno 1 - 10
of 328
pro vyhledávání: '"Stylianos Michalakis"'
Autor:
Lisa Maria Riedmayr, Klara Sonnie Hinrichsmeyer, Stefan Bernhard Thalhammer, David Manuel Mittas, Nina Karguth, Dina Yehia Otify, Sybille Böhm, Valentin Johannes Weber, Michael David Bartoschek, Victoria Splith, Manuela Brümmer, Raphael Ferreira, Nanda Boon, Gabriele Maria Wögenstein, Christian Grimm, Jan Wijnholds, Verena Mehlfeld, Stylianos Michalakis, Stefanie Fenske, Martin Biel, Elvir Becirovic
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Large genes including several CRISPR-Cas modules like gene activators (CRISPRa) require dual adeno-associated viral (AAV) vectors for an efficient in vivo delivery and expression. Current dual AAV vector approaches have important limitations
Externí odkaz:
https://doaj.org/article/ed8130e2a4b84e5eb1442fbb00645d85
Autor:
Cornelia Hiemenz, Nadine Baumeister, Constanze Helbig, Andrea Hawe, Sabrina Babutzka, Stylianos Michalakis, Wolfgang Friess, Tim Menzen
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101162- (2023)
Recombinant adeno-associated viruses (rAAVs) are attractive therapeutic viral vectors for gene delivery. To ensure the efficacy and safety of rAAV-based therapies, comprehensive characterization of the adeno-associated virus (AAV) capsids is essentia
Externí odkaz:
https://doaj.org/article/021bc972a55c4085adb2165aff1ec1da
Autor:
Surabhi Kandaswamy, Lena Zobel, Bina John, Sathiyavedu Thyagarajan Santhiya, Jacqueline Bogedein, Gerhard K. H. Przemeck, Valérie Gailus-Durner, Helmut Fuchs, Martin Biel, Martin Hrabĕ de Angelis, Jochen Graw, Stylianos Michalakis, Oana Veronica Amarie
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Retinitis pigmentosa is a group of progressive inherited retinal dystrophies that may present clinically as part of a syndromic entity or as an isolated (nonsyndromic) manifestation. In an Indian family suffering from retinitis pigmentosa, w
Externí odkaz:
https://doaj.org/article/64371217682f4adeb05ba3804086516f
Autor:
Victor Brantl, Benedikt Schworm, Gregor Weber, Johannes Schiefelbein, Thomas C. Kreutzer, Stylianos Michalakis, Jakob Siedlecki, Siegfried G. Priglinger
Publikováno v:
BMC Ophthalmology, Vol 21, Iss 1, Pp 1-6 (2021)
Abstract Importance A small number of COVID-19 patients has been reported to suffer from acute keratoconjunctivitis. In very rare cases, acute inflammatory retinal vein occlusion, papillophlebitis or retinopathy have been observed. Objective To deter
Externí odkaz:
https://doaj.org/article/52bc937f7f9249778b9b46f8849cc6cc
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Microglia are the main resident immune cells of the nervous system and as such they are involved in multiple roles ranging from tissue homeostasis to response to insults and circuit refinement. While most knowledge about microglia comes from brain st
Externí odkaz:
https://doaj.org/article/d70db39d90da4162bb2681ff372ce53c
Autor:
Luisa D. Burgers, Yanfen Li, Stylianos Michalakis, Sarah Ciurus, Stefan Zahler, Rolf Müller, Robert Fürst
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 152, Iss , Pp 113174- (2022)
Angiogenesis contributes to the progression of several diseases including cancer or age-related macular degeneration and is crucially driven by pathologically hyperactive endothelial cells (ECs). Targeting angiogenic processes in ECs thus represents
Externí odkaz:
https://doaj.org/article/d1f76abd4f4941fc825c23a4546e2b78
Autor:
Franziska R. Traube, Dilara Özdemir, Hanife Sahin, Constanze Scheel, Andrea F. Glück, Anna S. Geserich, Sabine Oganesian, Sarantos Kostidis, Katharina Iwan, René Rahimoff, Grazia Giorgio, Markus Müller, Fabio Spada, Martin Biel, Jürgen Cox, Martin Giera, Stylianos Michalakis, Thomas Carell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is red
Externí odkaz:
https://doaj.org/article/135f870c99dd4995a292de8aef187119
Autor:
Elisa Murenu, Marina Pavlou, Lisa Richter, Kleopatra Rapti, Sabrina Just, Jasmina Cehajic-Kapetanovic, Neda Tafrishi, Andrew Hayes, Rachel Scholey, Robert Lucas, Hildegard Büning, Dirk Grimm, Stylianos Michalakis
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 587-600 (2021)
Inherited retinal dystrophies (IRDs) are characterized by progressive degeneration and loss of light-sensing photoreceptors. The most promising therapeutic approach for IRDs is gene supplementation therapy using viral vectors, which requires the pres
Externí odkaz:
https://doaj.org/article/37533d6c477c425d8123d2759419c7c9
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 269 (2023)
The visual process begins with the absorption of photons by photopigments of cone and rod photoreceptors in the retina. In this process, the signal is first amplified by a cyclic guanosine monophosphate (cGMP)-based signaling cascade and then convert
Externí odkaz:
https://doaj.org/article/9d25d2d742f14f57bb0e27379d02a057
Autor:
Luisa D. Burgers, Betty Luong, Yanfen Li, Matthias P. Fabritius, Stylianos Michalakis, Christoph A. Reichel, Rolf Müller, Robert Fürst
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112255- (2021)
Chronic inflammation is characterized by persisting leukocyte infiltration of the affected tissue, which is enabled by activated endothelial cells (ECs). Chronic inflammatory diseases remain a major pharmacotherapeutic challenge, and thus the search
Externí odkaz:
https://doaj.org/article/4d20bc27720141d9918bfdcaca1d4432