Protective role for kidney TREM2 ^high macrophages in obesity- and diabetes-induced kidney injury.

Autor: Subramanian A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: as3894@cornell.edu., Vernon KA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhou Y; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: zhouym35@mail.sysu.edu.cn., Marshall JL; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Alimova M; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Arevalo C; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhang F; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Slyper M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Waldman J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Montesinos MS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dionne D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen LT; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cuoco MS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dubinsky D; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Purnell J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Keller K; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sturner SH; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Grinkevich E; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ghoshal A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kotek A; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Trivioli G; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK; Nephrology Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Richoz N; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK., Humphrey MB; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Darby IG; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Miller SJ; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Xu Y; Institute of Dermatology and Venereology, Dermatology Hospital, Southern Medical University, Guangzhou, China., Weins A; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Chloe-Villani A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chang SL; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA, USA; Division of Urology, Brigham and Women's Hospital, Boston, MA, USA., Kretzler M; Internal Medicine, Department of Nephrology, University of Michigan, Ann Arbor, MI, USA., Rosenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shaw JL; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zimmerman KA; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Clatworthy MR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK; Cellular Genetics, Wellcome Sanger Institute, Hinxton, UK; NIHR Cambridge Biomedical Research Center, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Cambridge, UK., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Greka A; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: agreka@broadinstitute.org.

Publikováno v: Cell reports [Cell Rep] 2024 Jun 25; Vol. 43 (6), pp. 114253. Date of Electronic Publication: 2024 May 22.