Interleukin 1α Sustains the Expression of Inflammatory Factors in Human Pancreatic Cancer Microenvironment by Targeting Cancer-Associated Fibroblasts

Autor: Vegard Tjomsland, Anna Spångeus, Johanna Välilä, Per Sandström, Kurt Borch, Henrik Druid, Sture Falkmer, Ursula Falkmer, Davorka Messmer, Marie Larsson

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 8, Pp 664-675 (2011)

The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) is dynamic, with an extensive interaction between the stroma and tumor cells. The aim of this study was to delineate the cross talk between PDAC and cancer-associated fibroblasts (

Externí odkaz: https://doaj.org/article/c18effce14234386bb0abbcbc4992248

Evidence for presence and functional effects of Kv1.1 channels in β-cells: general survey and results from mceph/mceph mice.

Autor: Zuheng Ma, Catharina Lavebratt, Malin Almgren, Neil Portwood, Lars E Forsberg, Robert Bränström, Erik Berglund, Sture Falkmer, Frank Sundler, Nils Wierup, Anneli Björklund

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18213 (2011)

BACKGROUND:Voltage-dependent K(+) channels (Kv) mediate repolarisation of β-cell action potentials, and thereby abrogate insulin secretion. The role of the Kv1.1 K(+) channel in this process is however unclear. We tested for presence of Kv1.1 in dif

Externí odkaz: https://doaj.org/article/e295ca21d54b49e1a428fd1ebc35b673

Malignant presacral ghrelinoma with long-standing hyperghrelinaemia

Autor: Frank Sundler, Nils Wierup, Sture Falkmer, Ralf Wenzel, Ursula Falkmer, Richard P. Baum, Harshad R. Kulkarni, Thomas Gustafsson

Publikováno v: Falkmer, U G, Gustafsson, T, Wenzel, R, Wierup, N, Sundler, F, Kulkarni, H, Baum, R P & Falkmer, S E 2015, ' Malignant presacral ghrelinoma with long-standing hyperghrelinaemia ', Upsala Journal of Medical Sciences, vol. 120, no. 4, pp. 299-304 . https://doi.org/10.3109/03009734.2015.1054453
Upsala Journal of Medical Sciences

BACKGROUND: A 57-year old man with low-back pain was found to have a 3 × 3 × 3 cm presacral neuroendocrine tumour (NET) with widespread metastases, mainly to the skeleton. His neoplastic disease responded well to peptide receptor radionuclide thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdafa78a7bd684573e65db432a9ebee
https://doi.org/10.3109/03009734.2015.1054453

Abstracts: 11th International Conference on Developmental Coordination Disorder (DCD11)

Autor: Sture Falkmer, Marita Falkmer, C. Foster, Susan Morris, Simon M. Rosalie, Richard Parsons

Publikováno v: Journal of Comorbidity. 5:32-109

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::137e97fb881e3669c5be82d43bf43615
https://doi.org/10.15256/joc.2015.5.52

Intestinal CART is a regulator of GIP and GLP-1 secretion and expression

Autor: Emma Ahlqvist, Enming Zhang, Liliya Shcherbina, Nils Wierup, A.-H. Thorén Fischer, Anders Lindqvist, Henri Honka, Erik Renström, Jukka Koffert, Sture Falkmer

Publikováno v: Molecular and cellular endocrinology. 476

Impaired incretin effect is a culprit in Type 2 Diabetes. Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide controlling pancreatic islet hormone secretion and beta-cell survival. Here we studied the potential expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107aff1614e8819f3c277cc3f60eaf59
https://pubmed.ncbi.nlm.nih.gov/29627317