Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

Autor: Houlston, RS, Webb, E, Broderick, P, Pittman, AM, Di Bernardo, MC, Lubbe, S, Chandler, I, Vijayakrishnan, J, Sullivan, K, Penegar, S, Carvajal-Carmona, L, Howarth, K, Jaeger, E, Spain, SL, Walther, A, Barclay, E, Martin, L, Gorman, M, Domingo, E, Teixeira, AS, Kerr, D, Cazier, J-B, Niittymaki, I, Tuupanen, S, Karhu, A, Aaltonen, LA, Tomlinson, IPM, Farrington, SM, Tenesa, A, Prendergast, JGD, Barnetson, RA, Cetnarskyj, R, Porteous, ME, Pharoah, PDP, Koessler, T, Hampe, J, Buch, S, Schafmayer, C, Tepel, J, Schreiber, S, Voelzke, H, Chang-Claude, J, Hoffmeister, M, Brenner, H, Zanke, BW, Montpetit, A, Hudson, TJ, Gallinger, S, Campbell, H, Dunlop, MG, Study, COGENT, Consor, CCAS, Consortium, C, Assoc, ICCG

Publikováno v: Houlston, R S, Webb, E, Broderick, P, Pittman, A M, Di Bernardo, M C, Lubbe, S, Chandler, I, Vijayakrishnan, J, Sullivan, K, Penegar, S, Carvajal-Carmona, L, Howarth, K, Jaeger, E, Spain, S L, Walther, A, Barclay, E, Martin, L, Gorman, M, Domingo, E, Teixeira, A S, Kerr, D, Cazier, J-B, Niittymäki, I, Tuupanen, S, Karhu, A, Aaltonen, L A, Tomlinson, I P M, Farrington, S M, Tenesa, A, Prendergast, J, Barnetson, R A, Cetnarskyj, R, Porteous, M E, Pharoah, P D P, Koessler, T, Hampe, J, Buch, S, Schafmayer, C, Tepel, J, Schreiber, S, Völzke, H, Chang-Claude, J, Hoffmeister, M, Brenner, H, Zanke, B W, Montpetit, A, Hudson, T J, Gallinger, S & Campbell, H & Dunlop, M G 2008, ' Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer ', Nature Genetics, vol. 40, no. 12, pp. 1426-1435 . https://doi.org/10.1038/ng.262

Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci with similar effect sizes, we conducted a met

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