Defects in B-lymphopoiesis and B-cell maturation underlie prolonged B-cell depletion in ANCA-associated vasculitis.

Autor: Thiel J; Division of Rheumatology and Clinical Immunology, Medical University of Graz, Graz, Austria marta.rizzi@uniklinik-freiburg.de jens.thiel@medunigraz.at.; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Schmidt FM; Division of Clinical and Experimental Immunology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Lorenzetti R; Division of Rheumatology and Clinical Immunology, Medical University of Graz, Graz, Austria.; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Troilo A; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Janowska I; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Nießen L; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Pfeiffer S; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Staniek J; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Benassini B; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Bott MT; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Korzhenevich J; Division of Clinical and Experimental Immunology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Konstantinidis L; Department of Orthopedics and Trauma Surgery, University of Freiburg, Freiburg im Breisgau, Germany., Burgbacher F; Department of Orthopedics and Trauma Surgery, University of Freiburg, Freiburg im Breisgau, Germany., Dufner AK; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Frede N; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Voll RE; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.; Centre of Chronic Immunodeficiency, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Stuchly J; Department of Paediatric Haematology and Oncology, University Hospital Motol, Prague, Czech Republic., Bakardjieva M; Department of Paediatric Haematology and Oncology, University Hospital Motol, Prague, Czech Republic., Kalina T; Department of Paediatric Haematology and Oncology, University Hospital Motol, Prague, Czech Republic., Smulski CR; Medical Physics Department, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Bariloche, Argentina., Venhoff N; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Rizzi M; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany marta.rizzi@uniklinik-freiburg.de jens.thiel@medunigraz.at.; Division of Clinical and Experimental Immunology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; Centre of Chronic Immunodeficiency, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

Publikováno v: Annals of the rheumatic diseases [Ann Rheum Dis] 2024 Oct 21; Vol. 83 (11), pp. 1536-1548. Date of Electronic Publication: 2024 Oct 21.

Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells.

Autor: Staniek J; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Kalina T; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic., Andrieux G; Institute of Medical Bioinformatics and Systems Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), partner site Freiburg, and German Cancer Research Center (DKFZ), Heidelberg, Germany., Boerries M; Institute of Medical Bioinformatics and Systems Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), partner site Freiburg, and German Cancer Research Center (DKFZ), Heidelberg, Germany., Janowska I; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Fuentes M; Department of Medicine and General Cytometry Service-Nucleus, Proteomics Unit, CIBERONC CB16/12/00400, Cancer Research Center (IBMCC/CSIC/USAL/IBSAL), Universidad de Salamanca, Salamanca, Spain., Díez P; Department of Medicine and General Cytometry Service-Nucleus, Proteomics Unit, CIBERONC CB16/12/00400, Cancer Research Center (IBMCC/CSIC/USAL/IBSAL), Universidad de Salamanca, Salamanca, Spain.; Department of Immunology, Leiden University Medical Center, Leiden, Netherlands., Bakardjieva M; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic., Stancikova J; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic., Raabe J; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Neumann J; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Schwenk S; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Arpesella L; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Stuchly J; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic., Benes V; Genomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., García Valiente R; Department of Medicine and General Cytometry Service-Nucleus, Proteomics Unit, CIBERONC CB16/12/00400, Cancer Research Center (IBMCC/CSIC/USAL/IBSAL), Universidad de Salamanca, Salamanca, Spain., Fernández García J; Department of Medicine and General Cytometry Service-Nucleus, Proteomics Unit, CIBERONC CB16/12/00400, Cancer Research Center (IBMCC/CSIC/USAL/IBSAL), Universidad de Salamanca, Salamanca, Spain., Carsetti R; B Cell Unit, Immunology Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Piano Mortari E; B Cell Unit, Immunology Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Catala A; Department of Hematology, Institut de Recerca Hospital Sant Joan de Déu Barcelona, Barcelona, Spain., de la Calle O; Immunology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Sogkas G; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany., Neven B; Pediatric Hematology-Immunology and Rheumatology Department, University Hospital Necker-Enfants Malades, Paris, France., Rieux-Laucat F; Université de Paris, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, INSERM UMR 1163, Paris, France., Magerus A; Université de Paris, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, INSERM UMR 1163, Paris, France., Neth O; Department of Paediatric Infectious Diseases, Rheumatology and Immunology, Hospital Universitario Virgen del Rocio (HUVR), Instituto de Biomedicina de Sevilla (IBIS), Universidad de Sevilla/CSIC, Red de Investigación Traslacional en Infectología Pediátrica RITIP, Sevilla, Spain., Olbrich P; Department of Paediatric Infectious Diseases, Rheumatology and Immunology, Hospital Universitario Virgen del Rocio (HUVR), Instituto de Biomedicina de Sevilla (IBIS), Universidad de Sevilla/CSIC, Red de Investigación Traslacional en Infectología Pediátrica RITIP, Sevilla, Spain., Voll RE; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Alsina L; Department of Hematology, Institut de Recerca Hospital Sant Joan de Déu Barcelona, Barcelona, Spain.; Clinical Immunology and Primary Immunodeficiencies Unit, Department of Pediatric Allergy and Clinical Immunology, Hospital Sant Joan de Déu Barcelona, Barcelona, Spain., Allende LM; Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain., Gonzalez-Granado LI; Primary Immunodeficiencies Unit, Department of Pediatrics, Research Institute Hospital 12 Octubre (i+12), Madrid, Spain.; School of Medicine, Complutense University, Madrid, Spain., Böhler C; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Thiel J; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Division of Rheumatology and Clinical Immunology, Medical University Graz, Graz, Austria., Venhoff N; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Lorenzetti R; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Division of Rheumatology and Clinical Immunology, Medical University Graz, Graz, Austria., Warnatz K; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Department of Immunology, University Hospital Zurich, Zurich, Switzerland., Unger S; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Seidl M; Department of Pathology, University Medical Center Freiburg, Freiburg, Germany.; Institute of Pathology, Heinrich-Heine University and University Hospital of Düsseldorf, Düsseldorf, Germany., Mielenz D; Division of Molecular Immunology, Department of Internal Medicine III, Nikolaus Fiebiger Zentrum, Friedrich Alexander University Erlangen-Nürnberg, Erlangen, Germany., Schneider P; Department of Immunobiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Ehl S; Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany., Rensing-Ehl A; Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Smulski CR; Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Medical Physics Department, Centro Atómico Bariloche, Comisión Nacional de Energía Atómica (CNEA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Carlos de Bariloche, Argentina., Rizzi M; Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.; Division of Clinical and Experimental Immunology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

Publikováno v: Science immunology [Sci Immunol] 2024 Jan 12; Vol. 9 (91), pp. eadj5948. Date of Electronic Publication: 2024 Jan 12.

Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease.

Autor: Zuna J; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic. jan.zuna@lfmotol.cuni.cz.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic. jan.zuna@lfmotol.cuni.cz.; University Hospital Motol, Prague, Czech Republic. jan.zuna@lfmotol.cuni.cz., Hovorkova L; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic., Krotka J; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.; University Hospital Motol, Prague, Czech Republic., Koehrmann A; Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Bardini M; Tettamanti Research Center, Pediatrics, University of Milano-Bicocca/Fondazione Tettamanti, Monza, Italy., Winkowska L; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic., Fronkova E; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.; University Hospital Motol, Prague, Czech Republic., Alten J; Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Koehler R; Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany., Eckert C; Charité-Universitätsmedizin Berlin, Berlin, Germany., Brizzolara L; Tettamanti Research Center, Pediatrics, University of Milano-Bicocca/Fondazione Tettamanti, Monza, Italy., Trkova M; Centre for Medical Genetics and Reproductive Medicine GENNET, Prague, Czech Republic., Stuchly J; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic., Zimmermann M; Department of Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany., De Lorenzo P; EsPhALL Trial Data Center, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Valsecchi MG; EsPhALL Trial Data Center, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Conter V; Pediatric Hemato-Oncolgy, Fondazione MBBM/ASST-Monza, University of Milano-Bicocca, Monza, Italy., Stary J; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.; University Hospital Motol, Prague, Czech Republic., Schrappe M; Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Biondi A; Pediatric Hemato-Oncolgy, Fondazione MBBM/ASST-Monza, University of Milano-Bicocca, Monza, Italy., Trka J; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.; University Hospital Motol, Prague, Czech Republic., Zaliova M; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.; University Hospital Motol, Prague, Czech Republic., Cazzaniga G; Tettamanti Research Center, Pediatrics, University of Milano-Bicocca/Fondazione Tettamanti, Monza, Italy.; Medical Genetics, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Cario G; Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Publikováno v: Leukemia [Leukemia] 2022 Dec; Vol. 36 (12), pp. 2793-2801. Date of Electronic Publication: 2022 Aug 06.

The clinical value of circulating free tumor DNA in testicular germ cell tumor patients.

Autor: Boublikova L; Department of Pediatric Hematology and Oncology, Charles University and University Hospital Motol, Prague, Czech Republic; Department of Oncology, Charles University and Thomayer University Hospital, Prague, Czech Republic. Electronic address: ludmila.boublikova@lfmotol.cuni.cz., Kramarzova KS; Department of Pediatric Hematology and Oncology, Charles University and University Hospital Motol, Prague, Czech Republic., Zwyrtkova M; Department of Pediatric Hematology and Oncology, Charles University and University Hospital Motol, Prague, Czech Republic., Bakardjieva-Mihaylova V; Department of Pediatric Hematology and Oncology, Charles University and University Hospital Motol, Prague, Czech Republic., Stuchly J; Department of Pediatric Hematology and Oncology, Charles University and University Hospital Motol, Prague, Czech Republic., Rosova B; Department of Pathology and Molecular Medicine, Charles University and Thomayer University Hospital, Prague, Czech Republic., Kolostova K; Department of Laboratory Genetics, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic., Sonsky J; Department of Urology, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic., Kindlova E; Department of Oncology and Radiotherapy, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic., Zachoval R; Department of Urology, Charles University and Thomayer University Hospital, Prague, Czech Republic., Buchler T; Department of Oncology, Charles University and Thomayer University Hospital, Prague, Czech Republic., Trka J; Department of Pediatric Hematology and Oncology, Charles University and University Hospital Motol, Prague, Czech Republic.

Publikováno v: Urologic oncology [Urol Oncol] 2022 Sep; Vol. 40 (9), pp. 412.e15-412.e24. Date of Electronic Publication: 2022 Jun 18.

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