Hydroxyurea for children with sickle cell anemia in sub-Saharan Africa

Autor: Tshilolo, L, Tomlinson, G, Williams, TN, Santos, B, Olupot-Olupot, P, Lane, A, Aygun, B, Stuber, SE, Latham, TS, McGann, PT, Ware, RE, For the REACH investigators

BACKGROUND: Hydroxyurea is an effective treatment for sickle cell anemia, but few studies have been conducted in sub-Saharan Africa, where the burden is greatest. Coexisting conditions such as malnutrition and malaria may affect the feasibility, safe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a473a7feca4278508ddd1c253bf2bc1
http://hdl.handle.net/10044/1/65014

Hydroxyurea for Children and Adults with Hemoglobin SC Disease.

Autor: Dei-Adomakoh YA; Department of Haematology, University of Ghana Medical School, Accra, Ghana.; Department of Haematology, Korle Bu Teaching Hospital, Accra, Ghana., Segbefia CI; Department of Child Health, University of Ghana Medical School, Accra, Ghana.; Department of Child Health, Korle Bu Teaching Hospital, Accra, Ghana., Latham TS; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati.; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati., Lane AC; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati., Dzefi-Tettey K; Department of Radiology, Korle Bu Teaching Hospital, Accra, Ghana.; Department of Radiology, University of Health and Allied Sciences, Ho, Ghana., Amissah-Arthur K; Ophthalmology Unit, Department of Surgery, University of Ghana Medical School, Accra, Ghana.; Ophthalmology Unit, Department of Surgery, Korle Bu Teaching Hospital, Accra, Ghana., Corquaye O; Pharmacy Department, Korle Bu Teaching Hospital, Accra, Ghana., Korang L; Pharmacy Department, Korle Bu Teaching Hospital, Accra, Ghana., Mensah E; Department of Haematology, University of Ghana Medical School, Accra, Ghana., Ekpale P; Department of Haematology, University of Ghana Medical School, Accra, Ghana., Ghunney W; Department of Haematology, Korle Bu Teaching Hospital, Accra, Ghana., Tagoe LG; Department of Child Health, Korle Bu Teaching Hospital, Accra, Ghana., Oteng A; Department of Haematology, Korle Bu Teaching Hospital, Accra, Ghana., Amoako E; Department of Child Health, Korle Bu Teaching Hospital, Accra, Ghana., Schandorf E; Department of Child Health, Korle Bu Teaching Hospital, Accra, Ghana., Bankas E; Department of Haematology, Korle Bu Teaching Hospital, Accra, Ghana., Awuku NA; Department of Haematology, Korle Bu Teaching Hospital, Accra, Ghana., Seedah D; Department of Child Health, Korle Bu Teaching Hospital, Accra, Ghana., Stuber SE; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati.; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati., Smart LR; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati.; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati., Ware RE; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati.; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati.

Publikováno v: NEJM evidence [NEJM Evid] 2024 Dec 08, pp. EVIDoa2400402. Date of Electronic Publication: 2024 Dec 08.

Pharmacokinetic-Guided Hydroxyurea to Reduce Transfusions in Ugandan Children with Sickle Cell Anemia: Study Design of the Alternative Dosing And Prevention of Transfusions Trial.

Autor: Power-Hays A; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA., Namazzi R; Global Health Uganda, Kampala, Uganda.; Makerere University, Kampala, Uganda., Kato C; Global Health Uganda, Kampala, Uganda., McElhinney KE; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Conroy AL; Global Health Uganda, Kampala, Uganda.; Department of Pediatrics, School of Medicine, Indiana University, Indianapolis, Indiana, USA., Hume H; Division of Hematology/Oncology, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Québec, Canada.; Department of Pediatrics, Université de Montréal, Montreal, Québec, Canada., John C; Department of Pediatrics, School of Medicine, Indiana University, Indianapolis, Indiana, USA., O'Hara SM; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA., Stuber SE; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Lane A; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Latham TS; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Opoka RO; Aga Khan Medical College, Nairobi, Kenya., Ware RE; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

Publikováno v: Acta haematologica [Acta Haematol] 2024 Jun 05, pp. 1-12. Date of Electronic Publication: 2024 Jun 05.

Reducing transfusion utilization for children with sickle cell anemia in sub-Saharan Africa with hydroxyurea: Analysis from the phase I/II REACH trial.

Autor: Power-Hays A; Division of Hematology and Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA., Tomlinson GA; Department of Medicine, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada., Tshilolo L; Department of Medicine, Centre Hospitalier Monkole, Kinshasa, Congo., Santos B; Instituto Hematológico Pediátrico, Hospital Pediátrico David Bernardino, Luanda, Angola., Williams TN; KEMRI-Wellcome Trust Programme, Kilifi, Kenya., Olupot-Olupot P; Mbale Clinical Research Institute, Mbale Regional Referral and Teaching Hospital-Busitema University, Mbale, Uganda., Smart LR; Division of Hematology and Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA., Aygun B; Division of Hematology, Cohen Children's Medical Center of New York, New Hyde Park, New York, USA., Lane A; Division of Hematology and Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Stuber SE; Division of Hematology and Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Latham T; Division of Hematology and Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Ware RE; Division of Hematology and Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.

Publikováno v: American journal of hematology [Am J Hematol] 2024 Apr; Vol. 99 (4), pp. 625-632. Date of Electronic Publication: 2024 Feb 08.

Hydroxyurea with dose escalation for primary stroke risk reduction in children with sickle cell anaemia in Tanzania (SPHERE): an open-label, phase 2 trial.

Autor: Ambrose EE; Department of Paediatrics and Child Health, Catholic University of Health and Allied Sciences, Mwanza, Tanzania; Department of Paediatrics and Child Health, Bugando Medical Centre, Mwanza, Tanzania., Latham TS; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Songoro P; Department of Paediatrics and Child Health, Bugando Medical Centre, Mwanza, Tanzania., Charles M; Department of Laboratory Science, Bugando Medical Centre, Mwanza, Tanzania., Lane AC; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Stuber SE; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Makubi AN; Department of Internal Medicine, Bugando Medical Centre, Mwanza, Tanzania., Ware RE; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA., Smart LR; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA. Electronic address: luke.smart@cchmc.org.

Publikováno v: The Lancet. Haematology [Lancet Haematol] 2023 Apr; Vol. 10 (4), pp. e261-e271. Date of Electronic Publication: 2023 Mar 01.