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pro vyhledávání: '"Stubbs John K"'
Autor:
Roger A. Burges, Campbell Simon F, Stubbs John K, Donald G. Gardiner, John Edmund Arrowsmith, Peter Edward Cross, Kenneth J. Blackburn
Publikováno v:
Journal of medicinal chemistry. 29(9)
A series of dihydropyridines substituted at the 2-position by basic side chains are described and their potencies as calcium antagonists listed. One compound, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5- methoxycarbonyl-6-methyl-1
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2322
Dimethyl acetylenedicarboxylate with 4-ethoxyquinazoline and its 6-methyl derivative give tetramethyl 6-ethoxy-4aH-pyrido[1,2-a]quinazoline-1,2,3,4-tetracarboxylates, which by an acid catalysed ring-opening–ring-closure process isomerise to the cor