Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Stuart W. Ember"'
Autor:
Simon R. Scutts, Stuart W. Ember, Hongwei Ren, Chao Ye, Christopher A. Lovejoy, Michela Mazzon, David L. Veyer, Rebecca P. Sumner, Geoffrey L. Smith
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1953-1965.e4 (2018)
Summary: Virus infection is sensed by pattern recognition receptors (PRRs) detecting virus nucleic acids and initiating an innate immune response. DNA-dependent protein kinase (DNA-PK) is a PRR that binds cytosolic DNA and is antagonized by vaccinia
Externí odkaz:
https://doaj.org/article/2e9af660b028485482172474468ea970
Autor:
Ernst Schönbrunn, Nicholas J. Lawrence, Gary W. Reuther, Harshani R. Lawrence, Cyril H. Benes, Conor C. Lynch, Patricia Greninger, Paula J. Cranfill, Jin-Yi Zhu, Marilena Tauro, Muhammad Ayaz, Steven Gunawan, Norbert Berndt, Que T. Lambert, Stuart W. Ember
Table S1: Crystallographic data collection and refinement statistics Table S2: Inhibitory activity against other BET bromodomains Table S3: Bromodomain profiling data Fig. S1: Detailed binding interactions of compounds 1 - 5 in BRD4-1 Fig. S2: Compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a8658e8c0c794a279fbf75d3faea43
https://doi.org/10.1158/1535-7163.22504383.v1
https://doi.org/10.1158/1535-7163.22504383.v1
Autor:
Ernst Schönbrunn, Nicholas J. Lawrence, Gary W. Reuther, Harshani R. Lawrence, Cyril H. Benes, Conor C. Lynch, Patricia Greninger, Paula J. Cranfill, Jin-Yi Zhu, Marilena Tauro, Muhammad Ayaz, Steven Gunawan, Norbert Berndt, Que T. Lambert, Stuart W. Ember
Synergistic action of kinase and BET bromodomain inhibitors in cell killing has been reported for a variety of cancers. Using the chemical scaffold of the JAK2 inhibitor TG101348, we developed and characterized single agents which potently and simult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174289931beab104a62e35bd2bf1cb33
https://doi.org/10.1158/1535-7163.c.6537717.v1
https://doi.org/10.1158/1535-7163.c.6537717.v1
Autor:
Ernst Schönbrunn, Nicholas J. Lawrence, Gary W. Reuther, Harshani R. Lawrence, Cyril H. Benes, Conor C. Lynch, Patricia Greninger, Paula J. Cranfill, Jin-Yi Zhu, Marilena Tauro, Muhammad Ayaz, Steven Gunawan, Norbert Berndt, Que T. Lambert, Stuart W. Ember
Table S4: Kinome profiling data (Microsoft Excel sheet) Table S5: Cell line screening data (Microsoft Excel sheet)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229255a872f5f91718071196e1a1a877
https://doi.org/10.1158/1535-7163.22504377.v1
https://doi.org/10.1158/1535-7163.22504377.v1