Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform.

Autor: Liangxian Cao, Marla Weetall, Jenelle Bombard, Hongyan Qi, Tamil Arasu, William Lennox, Jean Hedrick, Josephine Sheedy, Nicole Risher, Peter C Brooks, Panayiota Trifillis, Christopher Trotta, Young-Choon Moon, John Babiak, Neil G Almstead, Joseph M Colacino, Thomas W Davis, Stuart W Peltz

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0168366 (2016)

Current anti-VEGF (Vascular Endothelial Growth Factor A) therapies to treat various cancers indiscriminately block VEGF function in the patient resulting in the global loss of VEGF signaling which has been linked to dose-limiting toxicities as well a

Externí odkaz: https://doaj.org/article/429e9fa300c64e3997b2fda5fbe6a256

Data from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties

Autor: Stuart W. Peltz, Joseph M. Colacino, Art Branstrom, Neil G. Almstead, Allan Jacobson, Thomas W. Davis, John Babiak, Young-Choon Moon, Janet Petruska, Ronald Kong, William Lennox, Seongwoo Hwang, Tamil Arasu, Hongyan Qi, Shirley Yeh, Nicole Risher, Jean Hedrick, Josephine Sheedy, Joshua Du, Wencheng Li, Jason D. Graci, Charles Romfo, Bansri Furia, Min Jung Kim, Jiyuan Ma, Katherine Cintron, Christopher Trotta, Marla Weetall, Liangxian Cao

PTC299 was identified as an inhibitor of VEGFA mRNA translation in a phenotypic screen and evaluated in the clinic for treatment of solid tumors. To guide precision cancer treatment, we performed extensive biological characterization of the activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b38cf3c29f914ea98d3f3c7be961d2f
https://doi.org/10.1158/1535-7163.c.6539454.v1

Supplementary Excel file-1 from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties

Autor: Stuart W. Peltz, Joseph M. Colacino, Art Branstrom, Neil G. Almstead, Allan Jacobson, Thomas W. Davis, John Babiak, Young-Choon Moon, Janet Petruska, Ronald Kong, William Lennox, Seongwoo Hwang, Tamil Arasu, Hongyan Qi, Shirley Yeh, Nicole Risher, Jean Hedrick, Josephine Sheedy, Joshua Du, Wencheng Li, Jason D. Graci, Charles Romfo, Bansri Furia, Min Jung Kim, Jiyuan Ma, Katherine Cintron, Christopher Trotta, Marla Weetall, Liangxian Cao

contains the raw data from the Microarrays study in the PTC299-resistant HT1080 cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ffd21a73c725157d53ebd64ecdca72
https://doi.org/10.1158/1535-7163.22509948.v1

Meta-analyses of deflazacort versus prednisone/prednisolone in patients with nonsense mutation Duchenne muscular dystrophy

Autor: Perry B Shieh, Gary Elfring, Panayiota Trifillis, Claudio Santos, Stuart W Peltz, Julie A Parsons, Susan Apkon, Basil T Darras, Craig Campbell, Craig M McDonald, Richard J Barohn, Enrico Bertini, Kate Bushby, Brigitte Chabrol, Emma Ciafaloni, Jaume Columer, Giacomi Pietro Comi, Anne Connolly, Richard S Finkel, Kevin M Flanigan, Nathalie Goemans, Michela Guglieri, Susan T Iannaccone, Kristi J Jones, Petra Kaufmann, Janbernd Kirschner, Jean K Mah, Katherine Mathews, Eugenio Mercuri, Francesco Muntoni, Yoram Nevo, Andrés Nascimento Osorio, Yann Péréon, Rosaline Quinlivan, J. Ben Renfroe, Barry Russman, Monique Ryan, Jacinda Sampson, Ulrike Schara, Kathryn Selby, Thomas Sejersen, Douglas M Sproule, H. Lee Sweeney, Már Tulinius, Juan J Vilchez, Giuseppe Vita, Thomas Voit, Stephanie Burns-Wechsler, Brenda Wong, Ted Abresch, Erik K Henricson, Kim Coleman, Michelle Eagle, Julaine Florence, Ed Gappmaier, Craig McDonald, Hoda Z Abdel-Hamid, Clemens Bloetzer, Russell J Butterfield, Jong-Hee Chae, Jahannaz Dastgir, Isabelle Desguerre, Raul G Escobar, Erika Finanger, Peter Heydemann, Imelda Hughes, Anna Kaminska, Peter Karachunski, Martin Kudr, Timothy Lotze, Alexandra Prufer de Queiroz Campos Araujo, Maria Bernadete Dutra de Resende, Gihan Tennekoon, Haluk Topaloglu, Ricardo Erazo Torricelli, Lindsay N Alfano, Meredith K James, Linda Lowes, Anna Mayhew, Elena S Mazzone, Leslie Nelson, Kristy J Rose

Publikováno v: Paediatrics Publications

Aim: Compare efficacies of deflazacort and prednisone/prednisolone in providing clinically meaningful delays in loss of physical milestones in patients with nonsense mutation Duchenne muscular dystrophy. Materials & methods: Placebo data from Phase I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e773db882a9b68ac18148646fe6a8d7
https://ir.lib.uwo.ca/context/paedpub/article/3206/viewcontent/843.pdf

Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties

Autor: Jiyuan Ma, Thomas W. Davis, Young-Choon Moon, Hongyan Qi, Stuart W. Peltz, Janet Petruska, Neil Gregory Almstead, Nicole Risher, Art Branstrom, Jean Hedrick, Seongwoo Hwang, Katherine Cintron, William Joseph Lennox, Charles M. Romfo, Tamil Arasu, Liangxian Cao, Josephine Sheedy, John Babiak, Min Jung Kim, Ronald Kong, Wencheng Li, Jason D. Graci, Allan Jacobson, Shirley Yeh, Christopher R. Trotta, Joshua Du, Joseph M. Colacino, Bansri Furia, Marla Weetall

Publikováno v: Molecular Cancer Therapeutics. 18:3-16

PTC299 was identified as an inhibitor of VEGFA mRNA translation in a phenotypic screen and evaluated in the clinic for treatment of solid tumors. To guide precision cancer treatment, we performed extensive biological characterization of the activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc21306fbe053e0ead2cdd503bd008ff
https://doi.org/10.1158/1535-7163.mct-18-0863