Výsledky vyhledávání - "Stuart Turnbull"

Autor: Andrew Stuart Turnbull

Publikováno v: Emerging Library & Information Perspectives. 2:6-29

Computer software media has long had intrinsic similarities to books...so why may one be borrowed in a library and not the other? The answer lies in the context and history of how computer media came to be. In this essay I explore the early history o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::646c6b3b14e5349d67e02b5a23e45159
https://doi.org/10.5206/elip.v2i1.5928

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Elektronická kniha

Enter the Darkness

Autor: Stuart Turnbull

Enter the Darkness is a collection of poetry documenting the feelings and experiences of the author over time. The poetry within is relatable and is guaranteed to make the reader connect with the experiences and feel what the writer was feeling.

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Copper-mediated formation of hydrogen peroxide from the amylin peptide: A novel mechanism for degeneration of islet cells in type-2 diabetes mellitus?

Autor: Lee Hayes, Atef A Masad, Omar M. A. El-Agnaf, Brian J. Tabner, Nigel J. Fullwood, Leanne J. Cooper, Stuart Turnbull, Fuyuki Kametani, David Allsop, Matthew J. German

Publikováno v: FEBS Letters. 581:3489-3493

Amyloid deposits derived from the amylin peptide accumulate within pancreatic islet beta-cells in most cases of type-2 diabetes mellitus (T2Dm). Human amylin 'oligomers' are toxic to these cells. Using two different experimental techniques, we found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be41fcbc0d7ed25836b9fa5654999c0f
https://doi.org/10.1016/j.febslet.2007.06.061

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A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on β-amyloid and α-synuclein

Autor: David Allsop, Omar M. A. El-Agnaf, Fiona E. Benson, Jennifer King, Brian J. Tabner, Stuart Turnbull

Publikováno v: Free Radical Research. 40:731-739

There is clear evidence implicating oxidative stress in the pathology of many neurodegenerative diseases. Reactive oxygen species (ROS) are the primary mediators of oxidative stress, and hydrogen peroxide, a key ROS, is generated during aggregation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28eb5e148f39da624e8d15700f62ded6
https://doi.org/10.1080/10715760600632545

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Generation of Hydrogen Peroxide from Mutant Forms of the Prion Protein Fragment PrP121−231

Autor: David Allsop, Stuart Turnbull, David R. Brown, Brian J. Tabner

Publikováno v: Biochemistry. 42:7675-7681

By means of electron spin resonance spectroscopy, in conjunction with the spin trapping technique, we have shown previously that Abeta and alpha-synuclein (aggregating proteins that accumulate in the brain in Alzheimer's disease, Parkinson's disease,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7249d1f994995c5513c2d60061777ce
https://doi.org/10.1021/bi030036e

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Copper-dependent generation of hydrogen peroxide from the toxic prion protein fragment PrP106–126

Autor: David Allsop, Brian J. Tabner, David R. Brown, Stuart Turnbull

Publikováno v: Neuroscience Letters. 336:159-162

Oligomeric forms of many of the aggregating proteins associated with neurodegenerative diseases are toxic to cultured cells. We have shown recently that Aβ and α-synuclein can both induce the formation of hydroxyl radicals following incubation in s

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https://doi.org/10.1016/s0304-3940(02)01254-5

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New evidence that the Alzheimer β-amyloid peptide does not spontaneously form free radicals: An ESR study using a series of spin-traps

Autor: Omar M. A. El-Agnaf, Lance J. Twyman, Brian J. Tabner, Stuart Turnbull, David Allsop

Publikováno v: Free Radical Biology and Medicine. 30:1154-1162

The direct formation of free radicals from Abeta has been suggested to be a key neurotoxic mechanism in Alzheimer's disease (AD). We have explored the possibility of the spontaneous formation of peptide-derived free radicals during the incubation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b68ee6b71e3cbb657218ca3e28397e0
https://doi.org/10.1016/s0891-5849(01)00510-x

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The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?

Autor: David Allsop, Nigel J. Fullwood, Matthew J. German, Stuart Turnbull, Brian J. Tabner

Publikováno v: Lancaster University-Pure

By means of an ESR spin-trapping method, we have shown that Aβ (amyloid β), α-synuclein and various toxic forms of the prion protein all appear to generate H2O2in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death i

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https://doi.org/10.1042/bst0330548

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3- p -toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide

Autor: David Allsop, Gillian L. Gibson, Stuart Turnbull, Ian K. Martin, Susan Moore, Lance J. Twyman

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:255-257

The cmc and IC50 values of the beta-amyloid (Abeta) aggregation inhibitors, 3-p-toluoyl-2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran 1, and 2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran 2 have been determined. After comparison of the cmc data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbbe079be8f0ea93bcfcdd93e28a404
https://doi.org/10.1016/s0960-894x(00)00645-4

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