Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Stuart T. Hamilton"'
Autor:
Ece Egilmezer, Stuart T. Hamilton, Charles S. P. Foster, Manfred Marschall, William D. Rawlinson
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Human cytomegalovirus (CMV) infection is the leading non-genetic aetiology of congenital malformation in developed countries, causing significant fetal neurological injury. This study investigated potential CMV pathogenetic mechanisms of fet
Externí odkaz:
https://doaj.org/article/d6dea77e2f39409cb1b7a2d949208ac3
Autor:
Ece Egilmezer, Stuart T. Hamilton, Glen Lauw, Jasmine Follett, Eric Sonntag, Martin Schütz, Manfred Marschall, William D. Rawlinson
Publikováno v:
Viruses, Vol 16, Iss 6, p 918 (2024)
Human cytomegalovirus (CMV) infection is the leading non-genetic cause of congenital malformation in developed countries, causing significant fetal injury, and in some cases fetal death. The pathogenetic mechanisms through which this host-specific vi
Externí odkaz:
https://doaj.org/article/af26405dbaf94078be2097abd1e33dd0
Autor:
Martin Schütz, Christina Wangen, Mona Sommerer, Melanie Kögler, Jan Eickhoff, Carsten Degenhart, Bert Klebl, Zin Naing, Ece Egilmezer, Stuart T. Hamilton, William D. Rawlinson, Heinrich Sticht, Manfred Marschall
Publikováno v:
Virus Research, Vol 335, Iss , Pp 199200- (2023)
Human cytomegalovirus (HCMV) infection is shaped by a tightly regulated interplay between viral and cellular proteins. Distinct kinase activities, such as the viral cyclin-dependent kinase ortholog (vCDK) pUL97 and cellular CDK7 are both crucial for
Externí odkaz:
https://doaj.org/article/ac8f839330fc4cb29be6a6ece1547fd9
Autor:
Martin Schütz, Regina Müller, Eileen Socher, Christina Wangen, Florian Full, Emanuel Wyler, Diana Wong, Myriam Scherer, Thomas Stamminger, Sunwen Chou, William D. Rawlinson, Stuart T. Hamilton, Heinrich Sticht, Manfred Marschall
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11814 (2022)
The complex host interaction network of human cytomegalovirus (HCMV) involves the regulatory protein kinase pUL97, which represents a viral cyclin-dependent kinase (CDK) ortholog. pUL97 interacts with the three human cyclin types T1, H, and B1, where
Externí odkaz:
https://doaj.org/article/1e8fe2e70fcc4f7a8d7709274b08ee92
Autor:
Friedrich Hahn, Stuart T. Hamilton, Christina Wangen, Markus Wild, Jintawee Kicuntod, Nadine Brückner, Jasmine E. L. Follett, Lars Herrmann, Ahmed Kheimar, Benedikt B. Kaufer, William D. Rawlinson, Svetlana B. Tsogoeva, Manfred Marschall
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12858 (2021)
Human cytomegalovirus (HCMV) is a major pathogenic herpesvirus that is prevalent worldwide and it is associated with a variety of clinical symptoms. Current antiviral therapy options do not fully satisfy the medical needs; thus, improved drug classes
Externí odkaz:
https://doaj.org/article/3b17ad2ff9d349dcb2279d6ff7b8f88d
Autor:
Karla J. Helbig, Rowena A. Bull, Rebecca Ambrose, Michael R. Beard, Helen Blanchard, Till Böcking, Brendon Chua, Agathe M. G. Colmant, Keaton M. Crosse, Damian F. J. Purcell, Johanna Fraser, Joshua A. Hayward, Stuart T. Hamilton, Matloob Husain, Robin MacDiarmid, Jason M. Mackenzie, Gregory W. Moseley, Thi H. O. Nguyen, Miguel E. Quiñones-Mateu, Karl Robinson, Chaturaka Rodrigo, Julio Rodriguez-Andres, Penny A. Rudd, Anja Werno, Peter White, Paul Young, Peter Speck, Merilyn Hibma, Heidi E. Drummer, Gilda Tachedjian
Publikováno v:
Viruses, Vol 12, Iss 6, p 621 (2020)
The Australasian Virology Society (AVS) aims to promote, support and advocate for the discipline of virology in the Australasian region. The society was incorporated in 2011 after 10 years operating as the Australian Virology Group (AVG) founded in 2
Externí odkaz:
https://doaj.org/article/6e907b1a42ed4dc9a447293a0e35a8b4
Autor:
Laura Graf, Rike Webel, Sabrina Wagner, Stuart T. Hamilton, William D. Rawlinson, Heinrich Sticht, Manfred Marschall
Publikováno v:
Viruses, Vol 5, Iss 12, Pp 3213-3230 (2013)
The human cytomegalovirus (HCMV)-encoded protein kinase, pUL97, is considered a cyclin-dependent kinase (CDK) ortholog, due to shared structural and functional characteristics. The primary mechanism of CDK activation is binding to corresponding cycli
Externí odkaz:
https://doaj.org/article/18bbe25ac1b140d98121592bcf1439be
Publikováno v:
Placenta. 112:62-65
Human cytomegalovirus congenital infection is the leading non-genetic cause of fetal malformation in developed countries. There are currently no safe antivirals for use during pregnancy. Placental trophoblast cells specifically secrete exosomes conta
Autor:
William D. Rawlinson, Markus Wild, Stuart T. Hamilton, Ahmed Kheimar, Manfred Marschall, Benedikt B. Kaufer, Jasmine E. L. Follett, Lars Herrmann, Jintawee Kicuntod, Svetlana B. Tsogoeva, Nadine Brückner, Friedrich Hahn, Christina Wangen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12858, p 12858 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12858
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12858
Human cytomegalovirus (HCMV) is a major pathogenic herpesvirus that is prevalent worldwide and it is associated with a variety of clinical symptoms. Current antiviral therapy options do not fully satisfy the medical needs; thus, improved drug classes
Autor:
William D. Rawlinson, Ece Egilmezer, Mirjam Steingruber, Manfred Marschall, Stuart T. Hamilton, Jens Milbradt, Corina Hutterer
Publikováno v:
Placenta. :10-19
Congenital cytomegalovirus (HCMV) infection may cause significant fetal malformation and in severe cases fetal and neonatal death. Fetal injury may be caused indirectly by the placental response to infection. Dual-specificity tyrosine phosphorylation