Human cytomegalovirus replication is strictly inhibited by siRNAs targeting UL54, UL97 or UL122/123 gene transcripts.

Autor: Stuart T Hamilton, Jens Milbradt, Manfred Marschall, William D Rawlinson

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e97231 (2014)

Human cytomegalovirus (HCMV) causes severe sequelae in immunocompromised hosts. Current antiviral therapies have serious adverse effects, with treatment in many clinical settings problematic, making new therapeutic approaches necessary. We examined t

Externí odkaz: https://doaj.org/article/c88c754fd4094e3195f941f2eec85799

Human cytomegalovirus-induces cytokine changes in the placenta with implications for adverse pregnancy outcomes.

Autor: Stuart T Hamilton, Gillian Scott, Zin Naing, Jenna Iwasenko, Beverley Hall, Nicole Graf, Susan Arbuckle, Maria E Craig, William D Rawlinson

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52899 (2012)

Human cytomegalovirus (CMV) infection of the developing fetus can result in adverse pregnancy outcomes including death in utero. Fetal injury results from direct viral cytopathic damage to the CMV-infected fetus, although evidence suggests CMV placen

Externí odkaz: https://doaj.org/article/5cff58329b434aeba5ee981421fe4bf8

Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency

Autor: Martin Schütz, Christina Wangen, Mona Sommerer, Melanie Kögler, Jan Eickhoff, Carsten Degenhart, Bert Klebl, Zin Naing, Ece Egilmezer, Stuart T. Hamilton, William D. Rawlinson, Heinrich Sticht, Manfred Marschall

Publikováno v: Virus Research, Vol 335, Iss , Pp 199200- (2023)

Human cytomegalovirus (HCMV) infection is shaped by a tightly regulated interplay between viral and cellular proteins. Distinct kinase activities, such as the viral cyclin-dependent kinase ortholog (vCDK) pUL97 and cellular CDK7 are both crucial for

Externí odkaz: https://doaj.org/article/ac8f839330fc4cb29be6a6ece1547fd9

A placental specific miRNA miR-517a-3p exerts anti-human cytomegalovirus activity

Autor: Friedrich Hahn, Stuart T. Hamilton, Eric Sonntag, Manfred Marschall, William D. Rawlinson

Publikováno v: Placenta. 112:62-65

Human cytomegalovirus congenital infection is the leading non-genetic cause of fetal malformation in developed countries. There are currently no safe antivirals for use during pregnancy. Placental trophoblast cells specifically secrete exosomes conta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ff05d78875577baedc6921277e0e40
https://doi.org/10.1016/j.placenta.2021.06.013

Development of a PROTAC-Based Targeting Strategy Provides a Mechanistically Unique Mode of Anti-Cytomegalovirus Activity

Autor: William D. Rawlinson, Markus Wild, Stuart T. Hamilton, Ahmed Kheimar, Manfred Marschall, Benedikt B. Kaufer, Jasmine E. L. Follett, Lars Herrmann, Jintawee Kicuntod, Svetlana B. Tsogoeva, Nadine Brückner, Friedrich Hahn, Christina Wangen

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 12858, p 12858 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12858

Human cytomegalovirus (HCMV) is a major pathogenic herpesvirus that is prevalent worldwide and it is associated with a variety of clinical symptoms. Current antiviral therapy options do not fully satisfy the medical needs; thus, improved drug classes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025fe4cd9b48d660f9617837c866f6cb
https://www.mdpi.com/1422-0067/22/23/12858