Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Stuart T, Caldwell"'
Autor:
Jan Lj. Miljkovic, Nils Burger, Justyna M. Gawel, John F. Mulvey, Abigail A.I. Norman, Takanori Nishimura, Yoshiyuki Tsujihata, Angela Logan, Olga Sauchanka, Stuart T. Caldwell, Jordan L. Morris, Tracy A. Prime, Stefan Warrington, Julien Prudent, Georgina R. Bates, Dunja Aksentijević, Hiran A. Prag, Andrew M. James, Thomas Krieg, Richard C. Hartley, Michael P. Murphy
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102429- (2022)
Mitochondria-targeted H2S donors are thought to protect against acute ischemia-reperfusion (IR) injury by releasing H2S that decreases oxidative damage. However, the rate of H2S release by current donors is too slow to be effective upon administratio
Externí odkaz:
https://doaj.org/article/f01616a12f704ac39a2ca4515711e427
Autor:
Laura Pala, Hans M. Senn, Stuart T. Caldwell, Tracy A. Prime, Stefan Warrington, Thomas P. Bright, Hiran A. Prag, Claire Wilson, Michael P. Murphy, Richard C. Hartley
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
There is considerable interest in developing drugs and probes targeted to mitochondria in order to understand and treat the many pathologies associated with mitochondrial dysfunction. The large membrane potential, negative inside, across the mitochon
Externí odkaz:
https://doaj.org/article/55f3b6d8361e43d484624302dfb0660e
Autor:
Shinpei Uno, Alexander H. Harkiss, Roy Chowdhury, Stuart T. Caldwell, Tracy A. Prime, Andrew M. James, Brendan Gallagher, Julien Prudent, Richard C. Hartley, Michael P. Murphy
The targeting of bioactive molecules and probes to mitochondria can be achieved by coupling to the lipophilic triphenyl phosphonium (TPP) cation, which accumulates several hundred-fold within mitochondria in response to the mitochondrial membrane pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95a5af6fe0fa731cdfc5050043de79d
https://www.repository.cam.ac.uk/handle/1810/349471
https://www.repository.cam.ac.uk/handle/1810/349471
Autor:
Richard C. Hartley, Michael P. Murphy, Runa S.J. Lindblom, Sih Min Tan, Assam El-Osta, Thomas Krieg, Cesare Granata, Mark Ziemann, Stuart T. Caldwell, Melinda T. Coughlan, Mark E. Cooper, Vicki Thallas-Bonke, Carlos D. Baeza-Garza, Adrienne Laskowski, Matthew Snelson
Publikováno v:
Nutrients
Volume 13
Issue 5
Nutrients, Vol 13, Iss 1457, p 1457 (2021)
Volume 13
Issue 5
Nutrients, Vol 13, Iss 1457, p 1457 (2021)
Diabetic kidney disease (DKD) remains the number one cause of end-stage renal disease in the western world. In experimental diabetes, mitochondrial dysfunction in the kidney precedes the development of DKD. Reactive 1,2-dicarbonyl compounds, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f75a16aa5e2f18dbe9af515c64d012
Autor:
Filip Cvetko, John G. McCarron, Calum Wilson, Sean N O'Byrne, Michael P. Murphy, Stuart T. Caldwell, Richard C. Hartley
Publikováno v:
Chemical Communications (Cambridge, England)
Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c523af5d2b80a73cbb82446ba2c85a
Autor:
Rebecca H. Ritchie, Thomas Krieg, Runa S.J. Lindblom, Helen Kiriazis, Mitchel Tate, Richard C. Hartley, Melinda T. Coughlan, Miles J. De Blasio, Stuart T. Caldwell, Michael P. Murphy, Minh Deo, Gavin C Higgins, Darnel Prakoso, Min Park, Carlos D. Baeza-Garza
Publikováno v:
Cardiovascular Drugs and Therapy
Cardiovasc Drugs Ther
Cardiovasc Drugs Ther
Purpose Methylglyoxal, a by-product of glycolysis and a precursor in the formation of advanced glycation end-products, is significantly elevated in the diabetic myocardium. Therefore, we sought to investigate the mitochondria-targeted methylglyoxal s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa21a4ded8bf464bdea78cb55472c85
http://europepmc.org/articles/PMC6994445
http://europepmc.org/articles/PMC6994445
Autor:
Laura Tronci, Ana S. H. Costa, Efterpi Nikitopoulou, Krishnaa T. Mahbubani, Thomas Krieg, Jack Martin, Fay M Allen, Angela Logan, Timothy E. Beach, Elizabeth C. Hinchy, Kourosh Saeb-Parsy, Margaret M. Huang, Christian Frezza, Richard C. Hartley, Alan J. Robinson, Laura Pala, Michael P. Murphy, Hiran A. Prag, Mazin Hamed, Anja V. Gruszczyk, Andrew M. James, Stuart T. Caldwell
Publikováno v:
Nature metabolism
During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient1,2. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54eee6ea96375ae5f76308148cf2c23f
https://doi.org/10.1038/s42255-019-0115-y
https://doi.org/10.1038/s42255-019-0115-y
Autor:
Stuart T. Caldwell, Andrew Harrison, Michael P. Murphy, Alexander Negoda, Justyna M. Gawel, Richard C. Hartley, Andrew M. James, Kishore K. Gaddale Devanna, Evgeny Pavlov, Cristiane Benincá, Tracy A. Prime, Filip Cvetko
Publikováno v:
Chemical Communications (Cambridge, England)
TPB lipophilic anions deliver cargoes to lysosomes and are excluded from mitochondria.
Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δψ). TPB-conjugates also distributed across
Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δψ). TPB-conjugates also distributed across
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e8555d50df77a67c1b45be21c06490
https://pubmed.ncbi.nlm.nih.gov/33634803
https://pubmed.ncbi.nlm.nih.gov/33634803
Autor:
Michael P. Murphy, Richard C. Hartley, Hiran A. Prag, Tracy A. Prime, Thomas P. Bright, Claire Wilson, Laura Pala, Hans Martin Senn, Stuart T. Caldwell, Stefan Warrington
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Frontiers in Chemistry
Frontiers in Chemistry
There is considerable interest in developing drugs and probes targeted to mitochondria in order to understand and treat the many pathologies associated with mitochondrial dysfunction. The large membrane potential, negative inside, across the mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2d6615b358fdd5f970b2bd583fe5e7
https://www.frontiersin.org/article/10.3389/fchem.2020.00783/full
https://www.frontiersin.org/article/10.3389/fchem.2020.00783/full
Autor:
Stuart T. Caldwell, Duvaraka Kula-Alwar, Richard C. Hartley, Michael P. Murphy, Timothy E. Beach, Kourosh Saeb-Parsy, Laura Pala, Andrew M. James, Hiran A. Prag, Thomas Krieg
Publikováno v:
Molecular Pharmaceutics
Many mitochondrial metabolites and bioactive molecules contain two carboxylic acid moieties that make them unable to cross biological membranes. Hence, there is considerable interest in facilitating the uptake of these molecules into cells and mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28c49694b9a521f94fe06386bd73068
https://www.repository.cam.ac.uk/handle/1810/309294
https://www.repository.cam.ac.uk/handle/1810/309294