Zobrazeno 1 - 10 of 44 pro vyhledávání: '"Stuart Sims"'
1
Akademický článek
In Vitro Comparison of the Internal Ribosomal Entry Site Activity from Rodent Hepacivirus and Pegivirus and Construction of Pseudoparticles
Autor: Stuart Sims, Kevin Michaelsen, Sara Burkhard, Cornel Fraefel
Publikováno v: Advances in Virology, Vol 2021 (2021)
The 5′ untranslated region (5′ UTR) of rodent hepacivirus (RHV) and pegivirus (RPgV) contains sequence homology to the HCV type III internal ribosome entry sites (IRES). Utilizing a monocistronic expression vector with an RNA polymerase I promote
Externí odkaz: https://doaj.org/article/e82ef88a16e94a648ce1d623424d76b0
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2
Akademický článek
Adenoviral Vector Vaccination Induces a Conserved Program of CD8+ T Cell Memory Differentiation in Mouse and Man
Autor: Beatrice Bolinger, Stuart Sims, Leo Swadling, Geraldine O’Hara, Catherine de Lara, Dilair Baban, Natasha Saghal, Lian Ni Lee, Emanuele Marchi, Mark Davis, Evan Newell, Stefania Capone, Antonella Folgori, Ellie Barnes, Paul Klenerman
Publikováno v: Cell Reports, Vol 13, Iss 8, Pp 1578-1588 (2015)
Following exposure to vaccines, antigen-specific CD8+ T cell responses develop as long-term memory pools. Vaccine strategies based on adenoviral vectors, e.g., those developed for HCV, are able to induce and sustain substantial CD8+ T cell population
Externí odkaz: https://doaj.org/article/5a7c95e44b1148cba3efb8207f6e3cd7
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3
Akademický článek
Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities.
Autor: Ellen M Leitman, Christine D Palmer, Søren Buus, Fabian Chen, Lynn Riddell, Stuart Sims, Paul Klenerman, Asier Sáez-Cirión, Bruce D Walker, Paul R Hess, Marcus Altfeld, Philippa C Matthews, Philip J R Goulder
Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0184496 (2017)
Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most efficacious responses is critical to vaccine design. However, current methods depend on indirect
Externí odkaz: https://doaj.org/article/fb7a3d6217b74a1fa025d6dc51b45b58
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4
Akademický článek
Autophagy is a critical regulator of memory CD8+ T cell formation
Autor: Daniel J Puleston, Hanlin Zhang, Timothy J Powell, Elina Lipina, Stuart Sims, Isabel Panse, Alexander S Watson, Vincenzo Cerundolo, Alain RM Townsend, Paul Klenerman, Anna Katharina Simon
Publikováno v: eLife, Vol 3 (2014)
During infection, CD8+ T cells initially expand then contract, leaving a small memory pool providing long lasting immunity. While it has been described that CD8+ T cell memory formation becomes defective in old age, the cellular mechanism is largely
Externí odkaz: https://doaj.org/article/ce12fecbf3f241cfaec733408cc19eea
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5
Akademický článek
CD73 is dispensable for the regulation of inflationary CD8+ T-cells after murine cytomegalovirus infection and adenovirus immunisation.
Autor: Stuart Sims, Julia Colston, Beatrice Bolinger, Vince Emery, Paul Klenerman
Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114323 (2014)
The ecto-5'-nucleotidase (CD73) is expressed by T-cell subsets, myeloid derived suppressive cells and endothelial cells. It works in conjunction with CD39 to regulate the formation and degradation of adenosine in vivo. Adenosine has previously been s
Externí odkaz: https://doaj.org/article/ee85a5a5469c4f9495fe796e8b10c34d
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6
Akademický článek
A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirus.
Autor: Sarah Hutchinson, Stuart Sims, Geraldine O'Hara, Jon Silk, Uzi Gileadi, Vincenzo Cerundolo, Paul Klenerman
Publikováno v: PLoS ONE, Vol 6, Iss 2, p e14646 (2011)
Murine cytomegalovirus (MCMV) is an important animal model of human cytomegalovirus (HCMV), a β-Herpesvirus that infects the majority of the world's population and causes disease in neonates and immunocompromised adults. CD8(+) T cells are a major p
Externí odkaz: https://doaj.org/article/20b73904b1bc4d43bad785c96f20c01f
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7
Akademický článek
A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus.
Autor: Guo-Jen Huang, Adrian L Smith, Daniel H D Gray, Cormac Cosgrove, Benjamin H Singer, Andrew Edwards, Stuart Sims, Jack M Parent, Alyssa Johnsen, Richard Mott, Diane Mathis, Paul Klenerman, Christophe Benoist, Jonathan Flint
Publikováno v: PLoS Biology, Vol 8, Iss 12, p e1000561 (2010)
Neurogenesis continues through the adult life of mice in the subgranular zone of the dentate gyrus in the hippocampus, but its function remains unclear. Measuring cellular proliferation in the hippocampus of 719 outbred heterogeneous stock mice revea
Externí odkaz: https://doaj.org/article/7448670e6c53468698a30ec5ccd1c935
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10
Going beyond metric-driven responses to surveys: evaluating uses of UKES to support students' critical reflection on their learning gain
Autor: Juliet Winter, Cassie Lowe, Stuart Sims
Publikováno v: Lowe, C, Sims, S & Winter, J 2019, ' Going beyond metric-driven responses to surveys : evaluating uses of UKES to support students’ critical reflection on their learning gain ', Higher Education Pedagogies, vol. 4, no. 1, pp. 448-461 . https://doi.org/10.1080/23752696.2019.1672359
Higher Education Pedagogies, Vol 4, Iss 1, Pp 448-461 (2019)
Genuine engagement by academic staff and students in reflective practice in a time of great institutional pressure and a neo-liberal agenda for more metrics driven practice has become increasingly difficult to set time aside for. While more and more
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538162aab1c3ef408cfd2d287e40599e
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