Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Stuart Norman Lile Bennett"'
Autor:
Yoann Noblet, Stuart Norman Lile Bennett, Paul Murray, John Jeffers, Wojciech Roga, Daniel K. L. Oi, Stephen Marshall, Paul F. Griffin
In this paper we present an evolution of the single-pixel camera architecture, called “pushframe,” which addresses the limitations of pushbroom cameras in space-based applications. In particular, it is well-suited to observing fast-moving scenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd919e62ed6f414276adff18e59ae816
https://strathprints.strath.ac.uk/74395/1/Noblet_etal_AO_2020_Compact_multispectral_pushframe_camera_for.pdf
https://strathprints.strath.ac.uk/74395/1/Noblet_etal_AO_2020_Compact_multispectral_pushframe_camera_for.pdf
Autor:
Nathaniel G. Martin, Stuart Norman Lile Bennett, Christopher Tickner, Stephen Hallam, Leonie Campbell, Michael J. Waring
Publikováno v:
Tetrahedron Letters. 56:4904-4907
Epoxides are useful precursors for the synthesis of hydroxyl-bearing building blocks via Lewis acid catalyzed, nucleophilic ring opening. However, the reaction of glycidate esters with alcohol nucleophiles can be quite challenging with many of the cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8701973ab66ac5f2b99a0138264ddf78
https://doi.org/10.1016/j.tetlet.2015.06.080
https://doi.org/10.1016/j.tetlet.2015.06.080
Autor:
Wendy L. Snelson, Craig S. Donald, Cristian Bodin, Pablo Morentin Gutierrez, A. Gyte, James S. Scott, Frederick W. Goldberg, Sam D. Groombridge, Stuart Norman Lile Bennett, Andrew G. Leach
Publikováno v:
Journal of Medicinal Chemistry. 55:10652-10661
11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) has been a target of intensive research efforts across the pharmaceutical industry, due to its potential for the treatment of type II diabetes and other elements of the metabolic syndrome. To demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c155378b32b731417a2543475a9e683
https://doi.org/10.1021/jm3013163
https://doi.org/10.1021/jm3013163
Autor:
Paul Robert Owen Whittamore, Nidhal Selmi, Andy Stocker, Peter W. Kenny, Stuart Norman Lile Bennett, Adrian Pickup, Andrew D. Campbell, Alleyn T. Plowright, Craig Johnstone, David Whalley, Iain Simpson, Andrew Hancock
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3511-3514
A series of carboxylic acid glycogen phosphorylase inhibitors, which have potential as oral antidiabetic agents, is described. Defining and applying simple physicochemical design criteria was used to assess the opportunity and to focus synthetic effo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f5c3c4f7593eea071ca91aef6a97e5
https://doi.org/10.1016/j.bmcl.2010.04.147
https://doi.org/10.1016/j.bmcl.2010.04.147
Autor:
Christopher Tickner, Stephen Hallam, Stuart Norman Lile Bennett, Michael J. Waring, Nathaniel G. Martin, Leonie Campbell
Publikováno v:
ChemInform. 46
Primary, secondary, and tertiary alcohol nucleophiles are employed in the magnesium triflate catalyzed ring-opening of epoxide (I) to form the title products in moderate yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0286accbfd5fdd2cca45eb237fa53107
https://doi.org/10.1002/chin.201547066
https://doi.org/10.1002/chin.201547066
Autor:
Alexander G. Dossetter, Helen Pointon, Mark L. Fenwick, Gary Wilkinson, Sam D. Groombridge, David G.A. Morgan, Graeme R. Robb, Susan J. G. Loxham, David Baker, Stuart Norman Lile Bennett, Michael J. Waring, Jenny Morrell, Rob Garcia, Philip A. MacFaul, Jennie Georgsson, David M. Smith, Katie G. Maskill, Stephen Stokes
A series of 2-(pyridinyl)pyrimidines were identified as potent GPR40 antagonists. Despite significant challenges related to improving the combination of potency and lipophilicity within the series, the compounds were optimised to identify a suitable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f148b3f7ff76822b87760b13cc1915e2
Autor:
Guruprasad P. Aithal, Stuart Norman Lile Bennett, Ira Pande, Dominic P. Williams, Caroline Earnshaw, Rosalind E. Jenkins, Andrew V. Stachulski, Xiaoli Meng, B. Kevin Park, J. Gerry Kenna, Thomas G. Hammond, James L. Maggs, Sophie L. Regan, Anahi Santoyo Castelazo
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 350(2)
Covalent protein modifications by electrophilic acyl glucuronide (AG) metabolites are hypothetical causes of hypersensitivity reactions associated with certain carboxylate drugs. The complex rearrangements and reactivities of drug AG have been define
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c37d95314bec4db6206a162852810b1
https://pubmed.ncbi.nlm.nih.gov/24902585
https://pubmed.ncbi.nlm.nih.gov/24902585
Autor:
Michael Butters, Alan Martin Birch, Peter W. Kenny, Pawel Siedlecki, Paul Robert Owen Whittamore, Jennifer Whitehouse, Ludovic Otterbein, Matthew S. Addie, Andrew Pannifer, Melvyn J. Taylor, Paul M. Murray, Linda Godfrey, David Whalley, Andy Stocker, Jeremy S. Parker, Andrew David Morley, Nikos G. Oikonomakos, Kristy Readman, Linda A. Townsend, Stuart Norman Lile Bennett, Paul Schofield
Publikováno v:
Bioorganic & Medicinal Chemistry Letters 16:21(Nov2006):5567-5571
Two series of novel thienopyrrole inhibitors of recombinant human liver glycogen phosphorylase a (GPa) which are effective in reducing glucose output from rat hepatocytes are described. Representative compounds have been shown to bind at the dimer in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a027fdd96a6fc9f365265c8ad7e44fb1
https://pubmed.ncbi.nlm.nih.gov/16945526
https://pubmed.ncbi.nlm.nih.gov/16945526
Autor:
J. Matthew Wood, Derek Ogg, Graeme R. Robb, Robert D. M. Davies, Nathaniel G. Martin, Michael J. Waring, Leonie Campbell, Gary Wilkinson, Scott Boyd, Stuart Norman Lile Bennett, Philip A. MacFaul, David J. Hargreaves
Publikováno v:
MedChemComm. 4:663
The matched triplicate approach to lead optimisation offers a means of generating more robust quantitative structure activity relationship data and this rigour leads to better quality decision making and greater ability to predict optimal compounds w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21535df6df3329de3941445893236164
https://doi.org/10.1039/c3md20368a
https://doi.org/10.1039/c3md20368a
Autor:
Nathaniel G. Martin, Scott Boyd, David J. Hargreaves, Stefan Gerhardt, Gary Wilkinson, Graeme R. Robb, Leonie Campbell, Michael J. Waring, Stuart Norman Lile Bennett, Robert D. M. Davies
Publikováno v:
MedChemComm. 4:657
Successful lead optimisation requires the identification of the best compound within the chemical space explored during an optimisation campaign. This can be a costly and inefficient process leading to the synthesis of many sub-optimal compounds. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e834e115ceb2fbcd3042b9747711b008
https://doi.org/10.1039/c3md20367k
https://doi.org/10.1039/c3md20367k