Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Stuart N. Behncken"'
Autor:
Michael J. Waters, Stuart N. Behncken
Publikováno v:
Journal of Molecular Recognition. 12:355-362
Binding of growth hormone (GH) to its receptor (GHR) is a well-studied example of molecular recognition between a cytokine and its receptor. Extensive mutagenesis studies and several crystal structures have defined the key interactive amino acid resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a71fc7ec4a06e09e5d47c1a1d7035ad3
https://doi.org/10.1002/(sici)1099-1352(199911/12)12:6<355::aid-jmr477>3.0.co
https://doi.org/10.1002/(sici)1099-1352(199911/12)12:6<355::aid-jmr477>3.0.co
Autor:
S. P. Tam, Peter E. Lobie, H. Li, Bojiang Shen, C. A. Shang, Stuart N. Behncken, Michael J. Waters
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 26:760-764
1. The growth hormone (GH) receptor was the first of the class 1 cytokine receptors to be cloned. It shares a number of structural characteristics with other family members and common signalling mechanisms based on common usage of the Janus kinase 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5493436314a98aa7c4946c798e00e129
https://doi.org/10.1046/j.1440-1681.1999.03129.x
https://doi.org/10.1046/j.1440-1681.1999.03129.x
Autor:
Changmin Chen, Michael J. Waters, S. W. Rowlinson, Becky L. Conway-Campbell, Jennifer E. Rowland, Stuart N. Behncken
Publikováno v:
Letters in Peptide Science. 6:353-357
This article reviews the prospects for a small-molecule agonist of the growth hormone receptor in the light of current successes in identifying small agonist molecules for other homomeric class 1 cytokine receptors. A variety of mutagenic analyses on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9753d73b6a6117a5622b54f372ff9855
https://doi.org/10.1007/bf02443432
https://doi.org/10.1007/bf02443432
Autor:
S. W. Rowlinson, Stuart N. Behncken, William R. Baumbach, Michael J. Waters, Richard W. E. Clarkson, Zida Wu, Christian J. Strasburger, Jennifer E. Rowland
Publikováno v:
Journal of Biological Chemistry. 273:5307-5314
Signal transduction by the growth hormone receptor (GHR) occurs through growth hormone (GH)-induced dimerization of two GHRs to form a trimeric complex. It is thought that dimerization alone is sufficient for signaling, since monoclonal antibodies (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79952d763b137d66ffefd353e6f538fa
https://doi.org/10.1074/jbc.273.9.5307
https://doi.org/10.1074/jbc.273.9.5307
Autor:
S. W. Rowlinson, Becky L. Conway-Campbell, Jennifer E. Rowland, Stuart N. Behncken, Michael J. Waters, Thea A. Monks
Publikováno v:
Journal of Biological Chemistry. 272:27077-27083
It has been known for more than 4 decades that only primate growth hormones are effective in primate species, but it is only with the availability of the 2.8 A structure of the human growth hormone (hGH).hGH-binding protein (hGHBP)2 complex that Souz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ce0877bf90d3f6d6463be9a89b809c5
https://doi.org/10.1074/jbc.272.43.27077
https://doi.org/10.1074/jbc.272.43.27077
Autor:
Michael J. Waters, Jan Amstrup, Richard J. C. Brown, Becky L. Conway-Campbell, Stuart N. Behncken, Nils Billestrup
Publikováno v:
University of Copenhagen
Growth hormone initiates signaling by inducing homodimerization of two GH receptors. Here, we have sought to determine whether constitutively active receptor can be created in the absence of the extracellular domain by substituting it with high affin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b306f565a0379b3c0ac51f210cb5e84
https://curis.ku.dk/portal/en/publications/growth-hormone-ghindependent-dimerization-of-gh-receptor-by-a-leucine-zipper-results-in-constitutive-activation(d7d411fc-9f98-4953-a741-4aecfb4bcf3e).html
https://curis.ku.dk/portal/en/publications/growth-hormone-ghindependent-dimerization-of-gh-receptor-by-a-leucine-zipper-results-in-constitutive-activation(d7d411fc-9f98-4953-a741-4aecfb4bcf3e).html
