Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Stuart N Dunn"'
Autor:
Emily R. Webb, Silvia Lanati, Carol Wareham, Alistair Easton, Stuart N. Dunn, Tatyana Inzhelevskaya, Freja M. Sadler, Sonya James, Margaret Ashton-Key, Mark S. Cragg, Stephen A. Beers, Juliet C. Gray
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Immunotherapy offers a potentially less toxic, more tumor-specific treatment for neuroblastoma than conventional cytotoxic therapies. Accurate and reproducible immune competent preclinical models are key to understanding mechanisms of action
Externí odkaz:
https://doaj.org/article/1cd179c8bd0e4a0ba1a1db6fa9ea0186
Autor:
Juliet C. Gray, Martin J. Glennie, Mark S. Cragg, Peter W. Johnson, Sonya James, Stuart N. Dunn, Emily L. Williams
Figure S1 - PDF file 105K, Figure S1. Neuroblastoma cell lines do not express 4-1BB, CD40 or CTLA-4. The expression of 4-1BB, CD40 and CTLA-4 on naive and activated splenocytes (0.5 mg anti-CD3 i.v. 48 hr) and the neuroblastoma cell lines was determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97dabe738c42f60501acb167374e989a
https://doi.org/10.1158/1078-0432.22452687
https://doi.org/10.1158/1078-0432.22452687
Autor:
Juliet C. Gray, Martin J. Glennie, Mark S. Cragg, Peter W. Johnson, Sonya James, Stuart N. Dunn, Emily L. Williams
Purpose: Neuroblastoma is one of the commonest extracranial tumors of childhood. The majority of patients present with metastatic disease for which outcome remains poor. Immunotherapy is an attractive therapeutic approach for this disease, and a numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0f04b4715d3ab7e02cd3aa4ece42c1
https://doi.org/10.1158/1078-0432.c.6522552
https://doi.org/10.1158/1078-0432.c.6522552
Autor:
Emily R Webb, Sonya James, Tatyana Inzhelevskaya, Alistair Easton, Freja M Sadler, Silvia Lanati, Margaret Ashton-Key, Stephen A. Beers, Carol Wareham, Stuart N. Dunn, Juliet C. Gray, Mark S. Cragg
Publikováno v:
Webb, E R, Lanati, S, Wareham, C, Easton, A, Dunn, S N, Inzhelevskaya, T, Sadler, F M, James, S, Ashton-Key, M, Cragg, M S, Beers, S A & Gray, J C 2020, ' Immune characterization of pre-clinical murine models of neuroblastoma ', Scientific Reports, vol. 10, no. 1, 16695 . https://doi.org/10.1038/s41598-020-73695-9
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Immunotherapy offers a potentially less toxic, more tumor-specific treatment for neuroblastoma than conventional cytotoxic therapies. Accurate and reproducible immune competent preclinical models are key to understanding mechanisms of action, interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7040d338b2c88b82612dd7aba7ac602
https://hdl.handle.net/20.500.11820/f2df8389-6fef-4341-8e68-db28f884b7f7
https://hdl.handle.net/20.500.11820/f2df8389-6fef-4341-8e68-db28f884b7f7
Autor:
Björn Frendéus, Christine A. Penfold, Monika Semmrich, Emily L Williams, Steven G. Booth, Mats Jernetz, Anne Rogel, Ingrid Teige, Lekh N. Dahal, Jane E. Willoughby, Lang Dou, C. Ian Mockridge, J. Sjef Verbeek, Stuart N. Dunn, Kirstie L. S. Cleary, Juliet C. Gray, Chester Lai, Aymen Al-Shamkhani, Linda Mårtensson, Sarah L. Buchan, H.T. Claude Chan, Mark S. Cragg, Stephen A. Beers, Peter Johnson, Marcus Remer, Eugene Healy, Sonya James, Päivi Kannisto, Martin J. Glennie
Publikováno v:
Immunity. 49:958-970.e7
The costimulatory receptor 4-1BB is expressed on activated immune cells, including activated T cells. Antibodies targeting 4-1BB enhance the proliferation and survival of antigen-stimulated T cells in vitro and promote CD8 T cell-dependent anti-tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2971578b5fb5a1c4b51417d4ea86ef84
https://doi.org/10.1016/j.immuni.2018.09.014
https://doi.org/10.1016/j.immuni.2018.09.014
Publikováno v:
Cancer Research. 66:5436-5442
The graft-versus-leukemia effect of allogeneic stem-cell transplantation is believed to be mediated by T-cell recognition of minor histocompatibility antigens on recipient cells. For minor histocompatibility antigens HA-1 and HA-2, normal cell expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b49691dccf2fe6821f3338fd8f641dc
https://doi.org/10.1158/0008-5472.can-05-3130
https://doi.org/10.1158/0008-5472.can-05-3130
Autor:
Stuart N Dunn
Publikováno v:
EVA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c02b9bfcdbb742a8bc4703b2dda5fa61
https://doi.org/10.14236/ewic/eva2014.41
https://doi.org/10.14236/ewic/eva2014.41
Autor:
Stuart N. Dunn, Sonya James, Mark S. Cragg, Martin J. Glennie, Juliet C. Gray, Emily L Williams, Peter Johnson
Purpose: Neuroblastoma is one of the commonest extracranial tumors of childhood. The majority of patients present with metastatic disease for which outcome remains poor. Immunotherapy is an attractive therapeutic approach for this disease, and a numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9e57e15e0ae6af2dc86dd742713c4c
https://europepmc.org/articles/PMC3743027/
https://europepmc.org/articles/PMC3743027/
Autor:
Sarah L. Buchan, Freda K. Stevenson, Claes Öhlén, Philip D. Greenberg, Jason Rice, Timothy J. Kendall, Stuart N. Dunn, Michelle L. Dossett
Publikováno v:
Rice, J, Dossett, M L, Ohlén, C, Buchan, S L, Kendall, T J, Dunn, S N, Stevenson, F K & Greenberg, P D 2008, ' DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire ', European Journal of Immunology, vol. 38, no. 8, pp. 2118-30 . https://doi.org/10.1002/eji.200838213
The majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfea72f74413a9158a0dd56276e0278
https://www.pure.ed.ac.uk/ws/files/10644019/DNA_fusion_gene_vaccination_mobilizes_effective_anti_leukemic_cytotoxic_T_lymphocytes_from_a_tolerized_repertoire.pdf
https://www.pure.ed.ac.uk/ws/files/10644019/DNA_fusion_gene_vaccination_mobilizes_effective_anti_leukemic_cytotoxic_T_lymphocytes_from_a_tolerized_repertoire.pdf
Autor:
Ferdousi Chowdhury, Toby Mellows, Simon Mitchell, Stuart N. Dunn, Juliet C. Gray, Margaret Ashton-Key
Publikováno v:
OncoImmunology. 4:e1029701
Recent monoclonal antibody trials targeting the PD1/PD-L1 immune-checkpoint pathway have shown remarkable success in treating adult malignancies, with PD-L1-expressing tumors showing the most objective response. However, little is known as to whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38a04f4537c08d97d4472c89c8b30a36
https://doi.org/10.1080/2162402x.2015.1029701
https://doi.org/10.1080/2162402x.2015.1029701