Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Stuart N, Peirson"'
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background The natural light environment is far more complex than that experienced by animals under laboratory conditions. As a burrowing species, wild mice are able to self-modulate their light exposure, a concept known as light environment
Externí odkaz:
https://doaj.org/article/56b81e92f772420ab3f60dd2bdbe42f3
Autor:
Sara Hestehave, Roxana Florea, Alexander J.H. Fedorec, Maria Jevic, Lucile Mercy, Annia Wright, Oakley B. Morgan, Laurence A. Brown, Stuart N. Peirson, Sandrine M. Géranton
Publikováno v:
PAIN Reports, Vol 9, Iss 6, p e1213 (2024)
Abstract. Introduction:. Chronic pain is a hallmark of joint diseases. Although these conditions are often accompanied by negative affective symptoms including depression and anxiety, these comorbidities are rarely studied simultaneously in preclinic
Externí odkaz:
https://doaj.org/article/6a22647df48c415095a43d7794cc57ec
Autor:
Robert J Lucas, Annette E Allen, George C Brainard, Timothy M Brown, Robert T Dauchy, Altug Didikoglu, Michael Tri H Do, Brianna N Gaskill, Samer Hattar, Penny Hawkins, Roelof A Hut, Richard J McDowell, Randy J Nelson, Jan-Bas Prins, Tiffany M Schmidt, Joseph S Takahashi, Vandana Verma, Vootele Voikar, Sara Wells, Stuart N Peirson
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002535 (2024)
Light enables vision and exerts widespread effects on physiology and behavior, including regulating circadian rhythms, sleep, hormone synthesis, affective state, and cognitive processes. Appropriate lighting in animal facilities may support welfare a
Externí odkaz:
https://doaj.org/article/0c924f09db1d4bce8870e35320c9de9a
Autor:
Michael J. Gilhooley, Moritz Lindner, Teele Palumaa, Steven Hughes, Stuart N. Peirson, Mark W. Hankins
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 111-123 (2022)
During inherited retinal degenerations (IRDs), vision is lost due to photoreceptor cell death; however, a range of optogenetic tools have been shown to restore light responses in animal models. Restored response characteristics vary between tools and
Externí odkaz:
https://doaj.org/article/389b4ef8b91348ca90be5783efcfc4e6
Autor:
Gauri Ang, Laurence A. Brown, Shu K. E. Tam, Kay E. Davies, Russell G. Foster, Paul J. Harrison, Rolf Sprengel, Vladyslav V. Vyazovskiy, Peter L. Oliver, David M. Bannerman, Stuart N. Peirson
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Dysfunction of the glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluA1 subunit and deficits in synaptic plasticity are implicated in schizophrenia and sleep and circadian rhythm disruption. To investigate th
Externí odkaz:
https://doaj.org/article/db96924aa90f4475ae84a2e870b1ccac
Autor:
Aarti Jagannath, Norbert Varga, Robert Dallmann, Gianpaolo Rando, Pauline Gosselin, Farid Ebrahimjee, Lewis Taylor, Dragos Mosneagu, Jakub Stefaniak, Steven Walsh, Teele Palumaa, Simona Di Pretoro, Harshmeena Sanghani, Zeinab Wakaf, Grant C. Churchill, Antony Galione, Stuart N. Peirson, Detlev Boison, Steven A. Brown, Russell G. Foster, Sridhar R. Vasudevan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Sleep pressure and circadian rhythms influence one another. However, the regulatory mechanisms are unclear. Here, the authors show that adenosine A1/A2A receptor antagonists, such as caffeine, shift circadian rhythms and enhance the effects of light,
Externí odkaz:
https://doaj.org/article/fe29a732cf334692a98923abc1d068d8
Autor:
Tara C. Delorme, Shashank B. Srikanta, Angus S. Fisk, Marie-Ève Cloutier, Miho Sato, Carina A. Pothecary, Chantal Merz, Russell G. Foster, Steven A. Brown, Stuart N. Peirson, Nicolas Cermakian, Gareth T. Banks
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Mistimed exposure to light has been demonstrated to negatively affect multiple aspects of physiology and behavior. Here we analyzed the effects of chronic exposure to abnormal lighting conditions in mice. We exposed mice for 1 year to either: a stand
Externí odkaz:
https://doaj.org/article/d5a5dc5b40e74d4baf83746ada31a086
Autor:
Timothy M. Brown, George C. Brainard, Christian Cajochen, Charles A. Czeisler, John P. Hanifin, Steven W. Lockley, Robert J. Lucas, Mirjam Münch, John B. O’Hagan, Stuart N. Peirson, Luke L. A. Price, Till Roenneberg, Luc J. M. Schlangen, Debra J. Skene, Manuel Spitschan, Céline Vetter, Phyllis C. Zee, Kenneth P. Wright
Publikováno v:
PLoS Biology, Vol 20, Iss 3 (2022)
Ocular light exposure has important influences on human health and well-being through modulation of circadian rhythms and sleep, as well as neuroendocrine and cognitive functions. Prevailing patterns of light exposure do not optimally engage these ac
Externí odkaz:
https://doaj.org/article/d0bcc6f82fcb489ead3445e29aef6251
Autor:
Tatjana Lalic, Aiste Steponenaite, Liting Wei, Sridhar R. Vasudevan, Alistair Mathie, Stuart N. Peirson, Gurprit S. Lall, M. Zameel Cader
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The suprachiasmatic nucleus (SCN) ensures rhythmic electrical activity that varies between day and night to determine circadian behaviours. The authors show that TRESK channels provide a feedback mechanism to maintain the SCN in the appropriate state
Externí odkaz:
https://doaj.org/article/92d80056b5bc4ccbb603e1addb6b05b5
Autor:
Laura C. E. Steel, Selma Tir, Shu K. E. Tam, James N. Bussell, Manuel Spitschan, Russell G. Foster, Stuart N. Peirson
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2022)
Light is known to exert powerful effects on behavior and physiology, including upon the amount and distribution of activity across the day/night cycle. Here we use home cage activity monitoring to measure the effect of differences in home cage light
Externí odkaz:
https://doaj.org/article/79bca56331174fa48df4b20d59db0e58