Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Stuart McLaren"'
Autor:
Sandrine Boyault, Laura Van't Veer, Serge Dronov, Alain Viari, David C. Wedge, Xavier Pivot, Jos Jonkers, Dominik Glodzik, Se Jin Jang, Sandro Morganella, Hee Jin Lee, Marcel Smid, Serena Nik-Zainal, Hyung-Yong Kim, Steven Van Laere, Iris Pauporté, Ludmil B. Alexandrov, Gilles Romieu, Sancha Martin, Sarah O’Meara, Sunil R. Lakhani, Lucy R. Yates, Åke Borg, Michael R. Stratton, Ewan Birney, Miriam Ragle Aure, Young Seok Ju, Olafur A. Stefansson, Andrea L. Richardson, Helen Davies, Carlos Caldas, Andrew Menzies, Gerrit K. J. Hooijer, Luc Dirix, Anne Lise Børresen-Dale, Gilles Thomas, Moritz Gerstung, Gu Kong, Naoto T. Ueno, Andrew Tutt, Anita Langerød, Kamna Ramakrishnan, Paul N. Span, Jorunn E. Eyfjord, Johan Staaf, Rebecca Shepherd, Lucy Stebbings, David Jones, Jeong-Yeon Lee, Markus Ringnér, Jane E. Brock, Annegien Broeks, Peter T. Simpson, Stian Knappskog, Manasa Ramakrishna, Gert Van den Eynden, P. Andrew Futreal, Ole Christian Lingjærde, Hendrik G. Stunnenberg, Isabelle Treilleux, Xueqing Zou, Savitri Krishnamurthy, Tari A. King, Sung-Min Ahn, Inigo Martincorena, John A. Foekens, Christine Desmedt, John W.M. Martens, Marc J. van de Vijver, Alastair M Thompson, Anieta M. Sieuwerts, Germán Fg Rodríguez-González, Aquila Fatima, Ville Mustonen, Peter J. Campbell, Keiran Raine, Stefania Tommasi, Anne Vincent-Salomon, Yang Li, Colin A. Purdie, Peter B. Vermeulen, Arie B. Brinkman, Adam Butler, Jon W. Teague, Peter Van Loo, Stuart McLaren, Christos Sotiriou, Benita Kiat Tee Bk Tan
Publikováno v:
Nature
Nature (London)
Nature (London)
In the Methods section of this Article, 'greater than' should have been 'less than' in the sentence 'Putative regions of clustered rearrangements were identified as having an average inter-rearrangement distance that was at least 10 times greater tha
Autor:
Luke Marsden, Colin Cooper, Jorge Zamora, Barbara Kremeyer, Jonathan Kay, Steven Hazell, Mahbubl Ahmed, Tim Dudderidge, Edward Rowe, Hongwei Zhang, William Howat, Freddie C. Hamdy, Tapio Visakorpi, Paul C. Boutros, Gunes Gundem, Bissan Al-Lazikani, S. Edwards, David C. Wedge, Inigo Martincorena, Charles E. Massie, Douglas F. Easton, Gerhardt Attard, Nicholas van As, Anne Y. Warren, Dan J. Woodcock, Naomi Livni, Johann S. de Bono, Nening Dennis, Adam Lambert, Clare Verrill, Alan Thompson, Niedzica Camacho, Daniel Leongamornlert, William B. Isaacs, Christopher S. Foster, Hayley C. Whitaker, Pardeep Kumar, Daniel Brewer, Christopher Greenman, Declan Cahill, Simon Tavaré, Yong-Jie Lu, Stuart McLaren, Ultan McDermott, David T. Jones, Sue Merson, Rosalind A. Eeles, Vincent Khoo, Steve Hawkins, Daniel M. Berney, Cyril Fisher, Hayley J. Luxton, Lucy Matthews, Ludmil B. Alexandrov, G. Steven Bova, Adam Butler, David Nicol, Andy G. Lynch, Michael Fraser, Tokhir Dadaev, Keiran Raine, Mohammed J. R. Ghori, Katalin Karaszi, Jon W. Teague, Chris Sander, Robert G. Bristow, Peter Van Loo, Nimish Shah, Chris Ogden, Paul Workman, Andrew Menzies, Lucy Stebbings, Stefan C. Dentro, Cathy Corbishley, Thomas J. Mitchell, Zsofia Kote-Jarai, Pelvender Gill, Andrew Futreal, Elizabeth Bancroft, David E. Neal, Sarah Thomas, Anthony C. H. Ng, Erik Mayer, Yongwei Yu, Vincent Gnanapragasam, Valeria Bo
Publikováno v:
Nature genetics, vol 50, iss 5
Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer samples. From joint analysis of t
Autor:
Per Eystein Lønning, Andrew Menzies, Young Seok Ju, Hans Kristian Haugland, Turid Aas, Lucy R. Yates, Jonathan Hinton, Moritz Gerstung, April Greene-Colozzi, Denis Larsimont, Andrea L. Richardson, Bing B Jiang, Pierre-Yves Adnet, Delphine Vincent, L. Alexandrov, Marion Maetens, Gunes Gundem, Sancha Martin, Dominic D Glodzik, Helen Davies, Laura Mudie, Michael R. Stratton, Serena Nik-Zainal, Manasa Ramakrishna, Stian Knappskog, Aquila Fatima, Michail Ignatiadis, Christine Desmedt, David C. Wedge, Peter J. Campbell, Keiran Raine, Peer Kaare Lilleng, David T. Jones, Stuart McLaren, Yang Li, Christos Sotiriou, Adam Butler, Peter Van Loo
Publikováno v:
Nature medicine
The sequencing of cancer genomes may enable tailoring of therapeutics to the underlying biological abnormalities driving a particular patient's tumor. However, sequencing-based strategies rely heavily on representative sampling of tumors. To understa
Autor:
Andrew Menzies, Lucy Stebbings, Philip H. Jones, Stuart McLaren, David C. Wedge, Inigo Martincorena, Michael R. Stratton, Ludmil B. Alexandrov, Peter Van Loo, Peter R. Ellis, Peter J. Campbell, Moritz Gerstung, Anthony Fullam, Sara Widaa, Jose M. C. Tubio, Amit Roshan
Publikováno v:
Science. 348:880-886
Normal skin's curiously abnormal genome Within every tumor, a battle is being waged. As individual tumor cells acquire new mutations that promote their survival and growth, they clonally expand at the expense of tumor cells that are “less fit.” M
Publikováno v:
Small Enterprise Research. 21:190-201
Technological and legislative safety solutions will only succeed if the social systems, attitudes and behaviours at work support them. Safety climate is one of the factors related to effective hazard management, including management of noise. Data on
Autor:
Michael R. Stratton, Stuart McLaren, Roberto Tirabosco, Adrienne M. Flanagan, Gunes Gundem, Susanna L. Cooke, Serena Nik-Zainal, Adam Butler, Jon W. Teague, Dina Halai, Patrick S. Tarpey, Peter Van Loo, Susanne Scheipl, Sancha Martin, Helen Davies, David C. Wedge, P. Andrew Futreal, Peter J. Campbell, Gernot Jundt, Nischalan Pillay, Bhavisha Khatri, Sam Behjati, Victoria Goodie, Ben Robinson, Daniel Baumhoer, M Fernanda Amary, Nadege Presneau, Rifat Hamoudi, Ola Myklebost
Publikováno v:
Nature Genetics. 45:1479-1482
It is recognized that some mutated cancer genes contribute to the development of many cancer types, whereas others are cancer type specific. For genes that are mutated in multiple cancer classes, mutations are usually similar in the different affecte
Autor:
Ultan McDermott, Mingming Jia, Adam Butler, Stephen J. Gamble, Jon W. Teague, Andrew Menzies, Michael R. Stratton, P. Andrew Futreal, Peter Van Loo, Scott M. Lippman, Jonathan Hinton, Graham R. Bignell, Calli Latimer, Stuart McLaren, Serena Nik-Zainal, David C. Wedge, Peter J. Campbell, Yoshitsugu Mitani, Philip J. Stephens, David T. Jones, Keiran Raine, David J. McBride, John Gamble, Laura Mudie, Adam Shlien, Ignacio Varela, Mark Maddison, Alagu Jayakumar, Sarah O’Meara, Angela Cheverton, Helen Davies, Claire Hardy, Ian Whitmore, Patrick S. Tarpey, Elli Papaemmanuil, Adel K. El-Naggar
Publikováno v:
Journal of Clinical Investigation. 123:2965-2968
Adenoid cystic carcinoma (ACC) is a rare malignancy that can occur in multiple organ sites and is primarily found in the salivary gland. While the identification of recurrent fusions of the MYB-NFIB genes have begun to shed light on the molecular und
Autor:
P. Andrew Futreal, Susanna L. Cooke, Masoud Zamani Esteki, Ligia Mateiu, Jon W. Teague, Niels Van der Aa, Adam Butler, Meng-Lay Lin, Michael R. Stratton, Thierry Voet, David J. McBride, Yves Moreau, Joris Vermeesch, Peter Van Loo, Graham R. Bignell, Parveen Kumar, Michael A. Quail, Thomas D'Hooghe, Stuart McLaren, Peter J. Campbell, Keiran Raine, John Marshall, Lucy Stebbings
Publikováno v:
Nucleic Acids Research
The nature and pace of genome mutation is largely unknown. Because standard methods sequence DNA from populations of cells, the genetic composition of individual cells is lost, de novo mutations in cells are concealed within the bulk signal and per c
Autor:
David G. Bowen, Andrea Pellagatti, Paresh Vyas, Sarah O’Meara, Claire Hardy, Ilaria Ambaglio, Michael J. Groves, Peter J. Campbell, Keiran Raine, Jon Hinton, Mario Cazzola, Chris J. Yoon, Eva Hellström-Lindberg, Gunilla Walldin, Matteo G. Della Porta, Moritz Gerstung, Alex Sternberg, Calli Latimer, Luca Malcovati, Anthony R. Green, Laura Mudie, Adam Butler, Sudhir Tauro, Anna Gallì, Simon A. Forbes, David C. Wedge, Jon W. Teague, Jacqueline Boultwood, Peter Van Loo, Lynn Quek, Stuart McLaren, Carlo Gambacorti-Passerini, Elli Papaemmanuil, Nicholas C.P. Cross, Adam Shlien, Peter R. Ellis, Gunes Gundem, Michael R. Stratton
Myelodysplastic syndromes (MDS) are a heterogeneous group of chronic hematological malignancies characterized by dysplasia, ineffective hematopoiesis and a variable risk of progression to acute myeloid leukemia. Sequencing of MDS genomes has identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edd43afde4523c2e3712773bad31180
https://doi.org/10.1182/blood-2013-08-518886
https://doi.org/10.1182/blood-2013-08-518886
Autor:
Richard F. Schlenk, Gunes Gundem, Hartmut Döhner, Laura Mudie, Sarah O’Meara, Moritz Gerstung, Peter J. Campbell, Michael Heuser, Elli Papaemmanuil, Verena I. Gaidzik, Nicola D. Roberts, Lars Bullinger, Niccolo Bolli, Keiran Raine, Konstanze Döhner, Adam Butler, Jon W. Teague, David R. Jones, Nicola E. Potter, Peter Van Loo, Stuart McLaren, Mel Greaves, Arnold Ganser, Inigo Martincorena, Felicitas Thol, Peter Paschka, Peter Ganly
Publikováno v:
The New England journal of medicine. 374(23)
Recent studies have provided a detailed census of genes that are mutated in acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity defines the pathophysiology of AML and informs clinical practice.We enrolled a to