Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Stuart M. Cain"'
Autor:
Stuart M. Cain, Sascha R. A. Alles, Ray Gopaul, Louis-Philippe Bernier, Andrew C. Yung, Andrew Bauman, Yi Yang, Glen B. Baker, Piotr Kozlowski, Brian A. MacVicar, Terrance P. Snutch
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-14 (2023)
Abstract Familial hemiplegic migraine type-1 (FHM-1) is a form of migraine with aura caused by mutations in the P/Q-type (Cav2.1) voltage-gated calcium channel. Pregabalin, used clinically in the treatment of chronic pain and epilepsy, inhibits P/Q-t
Externí odkaz:
https://doaj.org/article/7f60fbce64114253a4fc70c967d52dd5
Autor:
Dan L. McElroy, Andrew J. Roebuck, Quentin Greba, Sumanta Garai, Asher L. Brandt, Orhan Yilmaz, Stuart M. Cain, Terrance P. Snutch, Ganesh A. Thakur, Robert B. Laprairie, John G. Howland
Publikováno v:
IBRO Neuroscience Reports, Vol 12, Iss , Pp 121-130 (2022)
Childhood absence epilepsy (CAE) is a non-convulsive seizure disorder primarily in children characterized by absence seizures. Absence seizures consist of 2.5–5 Hz spike-and-wave discharges (SWDs) detectable using electroencephalography (EEG). Curr
Externí odkaz:
https://doaj.org/article/b926279b3de946e6b0d7bbfc1871a059
Autor:
Kevin J. H. Allen, Ohyun Kwon, Matthew R. Hutcheson, Joseph J. Grudzinski, Stuart M. Cain, Frederic A. Cruz, Remitha M. Vinayakamoorthy, Ying S. Sun, Lindsay Fairley, Chandra B. Prabaharan, Ryan Dickinson, Valerie MacDonald-Dickinson, Maruti Uppalapati, Bryan P. Bednarz, Ekaterina Dadachova
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 979 (2023)
Background: Osteosarcoma (OS) represents the most common primary bone tumor in humans and in companion dogs, being practically phenotypically identical. There is a need for effective treatments to extend the survival of patients with OS. Here, we exa
Externí odkaz:
https://doaj.org/article/c4e817e3f39f4e6b99757ca74f03bafa
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Initially developed to generate new treatments for epilepsy, gabapentin, and pregabalin (“gabapentinoids”) were engineered to mimic the action of GABA and to modulate GABA metabolism. Rather than their intended pharmacological action on GABA neur
Externí odkaz:
https://doaj.org/article/02cb45047369467fb6fbd31197ca8032
Autor:
Jordan J. Shimell, Bhavin S. Shah, Stuart M. Cain, Samrat Thouta, Naila Kuhlmann, Igor Tatarnikov, D. Blair Jovellar, G. Stefano Brigidi, Jennifer Kass, Austen J. Milnerwood, Terrance P. Snutch, Shernaz X. Bamji
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2422-2437.e8 (2019)
Summary: Palmitoylation is a reversible post-translational lipid modification that facilitates vesicular transport and subcellular localization of modified proteins. This process is catalyzed by ZDHHC enzymes that are implicated in several neurologic
Externí odkaz:
https://doaj.org/article/fb1d68dc9602431a9df8d9734febf116
Publikováno v:
Neurobiology of Disease, Vol 94, Iss , Pp 106-115 (2016)
Childhood absence epilepsy (CAE) is often comorbid with behavioral and cognitive symptoms, including impaired visual memory. Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is an animal model closely resembling CAE; however, cognition in GAERS
Externí odkaz:
https://doaj.org/article/3f137259581846dbba219cf020b1036a
Autor:
Dadachova, Kevin J. H. Allen, Ohyun Kwon, Matthew R. Hutcheson, Joseph J. Grudzinski, Stuart M. Cain, Frederic A. Cruz, Remitha M. Vinayakamoorthy, Ying S. Sun, Lindsay Fairley, Chandra B. Prabaharan, Ryan Dickinson, Valerie MacDonald-Dickinson, Maruti Uppalapati, Bryan P. Bednarz, Ekaterina
Publikováno v:
Pharmaceuticals; Volume 16; Issue 7; Pages: 979
Background: Osteosarcoma (OS) represents the most common primary bone tumor in humans and in companion dogs, being practically phenotypically identical. There is a need for effective treatments to extend the survival of patients with OS. Here, we exa
Autor:
Timothy J. Onofrychuk, Terrance P. Snutch, Jonathan J. Simone, Ayat Zagzoog, Robert B. Laprairie, Quentin Greba, John G. Howland, Thaísa M. Sandini, Stuart M. Cain, Dan L. McElroy, Andrew J. Roebuck
Publikováno v:
European Journal of Neuroscience. 55:1063-1078
There is significant interest in the use of cannabinoids for the treatment of many epilepsies including absence epilepsy (AE). Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model many aspects of AE including the presence of spike-and-wave dis
Publikováno v:
Behavioural Brain Research. 361:54-64
Abnormalities in social behavior are a co-morbid symptom of idiopathic generalized epilepsies such as childhood absence epilepsy. The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model is a spontaneously occurring absence epilepsy phenotype
Autor:
Ayat Zagzoog, Jonathan J. Simone, Quentin Greba, Dan L. McElroy, Timothy J. Onofrychuk, John G. Howland, Stuart M. Cain, Terrance P. Snutch, Thaísa M. Sandini, Andrew J. Roebuck, Robert B. Laprairie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9086919228be64fc7c2f5384c7e60f88
https://doi.org/10.1111/ejn.15096/v2/response1
https://doi.org/10.1111/ejn.15096/v2/response1