Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Stuart M. Cahalan"'
Autor:
Swetha E Murthy, Adrienne E Dubin, Tess Whitwam, Sebastian Jojoa-Cruz, Stuart M Cahalan, Seyed Ali Reza Mousavi, Andrew B Ward, Ardem Patapoutian
Publikováno v:
eLife, Vol 7 (2018)
Mechanically activated (MA) ion channels convert physical forces into electrical signals, and are essential for eukaryotic physiology. Despite their importance, few bona-fide MA channels have been described in plants and animals. Here, we show that v
Externí odkaz:
https://doaj.org/article/21be4628362d442387f027bc248cfc59
Autor:
Jennifer M Kefauver, Kei Saotome, Adrienne E Dubin, Jesper Pallesen, Christopher A Cottrell, Stuart M Cahalan, Zhaozhu Qiu, Gunhee Hong, Christopher S Crowley, Tess Whitwam, Wen-Hsin Lee, Andrew B Ward, Ardem Patapoutian
Publikováno v:
eLife, Vol 7 (2018)
SWELL1 (LRRC8A) is the only essential subunit of the Volume Regulated Anion Channel (VRAC), which regulates cellular volume homeostasis and is activated by hypotonic solutions. SWELL1, together with four other LRRC8 family members, potentially forms
Externí odkaz:
https://doaj.org/article/e5adeb3c861446b49e6c931bba50f887
Autor:
Medha M. Pathak, Ian Parker, Francesco Marangoni, Stuart M. Cahalan, Joseph L. Dynes, Michael D. Cahalan, Jesse R. Holt, Amit Jairaman, Jamison L. Nourse, Milton L. Greenberg, Angel Zavala, Andriy V. Yeromin, Shivashankar Othy
Publikováno v:
Science Advances
Science advances, vol 7, iss 28
Science advances, vol 7, iss 28
Mechanosensitive Piezo1 channels restrict regulatory T cell expansion and limit disease remission in EAE.
T lymphocytes encounter complex mechanical cues during an immune response. The mechanosensitive ion channel, Piezo1, drives inflammatory re
T lymphocytes encounter complex mechanical cues during an immune response. The mechanosensitive ion channel, Piezo1, drives inflammatory re
Autor:
Stuart M Cahalan, Viktor Lukacs, Sanjeev S Ranade, Shu Chien, Michael Bandell, Ardem Patapoutian
Publikováno v:
eLife, Vol 4 (2015)
Red blood cells (RBCs) experience significant mechanical forces while recirculating, but the consequences of these forces are not fully understood. Recent work has shown that gain-of-function mutations in mechanically activated Piezo1 cation channels
Externí odkaz:
https://doaj.org/article/caf82672f9a6446cb872e15acfbdd93a
Autor:
Adrienne E. Dubin, Tess Whitwam, Sebastian Jojoa-Cruz, Stuart M. Cahalan, Swetha E. Murthy, Ardem Patapoutian, Andrew B. Ward, Seyed Ali Reza Mousavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18731611c18f72d527ab8f108ac236a6
https://doi.org/10.7554/elife.41844.019
https://doi.org/10.7554/elife.41844.019
Autor:
Daniel E. Mason, Eric C. Peters, Adrienne E. Dubin, Ardem Patapoutian, Stuart M. Cahalan, Mauricio Montal, Zhaozhu Qiu, Ruhma Syeda, Swetha E. Murthy, Maria N. Florendo, Jayanti Mathur
Publikováno v:
Cell. 164:499-511
The volume-regulated anion channel (VRAC) is activated when a cell swells, and plays a central role in maintaining cell volume in response to osmotic challenges. SWELL1 (LRRC8A) was recently identified as an essential component of VRAC. However, the
Autor:
William B. Kiosses, Emanuela Repetto, Sean Riley, Yasushi Kohno, Stuart M. Cahalan, M. Germana Sanna, Joan Heller Brown, Andrew D. McCulloch, Nhan Nguyen, Pedro J. Gonzalez-Cabrera, Steven J. Brown, Nora B. Leaf, Lusine Abgaryan, Kevin P. Vincent, Hugh Rosen
Publikováno v:
Molecular pharmacology, vol 89, iss 1
Sanna, MG; Vincent, KP; Repetto, E; Nguyen, N; Brown, SJ; Abgaryan, L; et al.(2016). Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction. MOLECULAR PHARMACOLOGY, 89(1), 176-186. doi: 10.1124/mol.115.100222. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/19v1t1kw
Sanna, MG; Vincent, KP; Repetto, E; Nguyen, N; Brown, SJ; Abgaryan, L; et al.(2016). Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction. MOLECULAR PHARMACOLOGY, 89(1), 176-186. doi: 10.1124/mol.115.100222. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/19v1t1kw
The molecular pharmacology of the G protein-coupled receptors for sphingosine 1-phosphate (S1P) provides important insight into established and new therapeutic targets. A new, potent bitopic S1P3 antagonist, SPM-354, with in vivo activity, has been u
Autor:
Andrew B. Ward, Tess Whitwam, Sebastian Jojoa Cruz, Ardem Patapoutian, Adrienne E. Dubin, Swetha E. Murthy, Seyed Ali Reza Mousavi, Stuart M. Cahalan
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
IntroductionMechanotransduction, the conversion of mechanical cues into biochemical signals, is crucial for many biological processes in plants and animals1,2. In mammals, some mechanosensory processes such as touch sensation and vascular development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5f1fb9bb9fba3b1fe173823352d07d
https://doi.org/10.1101/408732
https://doi.org/10.1101/408732
Autor:
Andrew B. Ward, Adrienne E. Dubin, Kei Saotome, Christopher A. Cottrell, Wen Hsin Lee, Zhaozhu Qiu, Jennifer M. Kefauver, Gunhee Hong, Tess Whitwam, Jesper Pallesen, Ardem Patapoutian, Christopher S. Crowley, Stuart M. Cahalan
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
SWELL1 (LRRC8A) is the only essential subunit of the Volume Regulated Anion Channel (VRAC), which regulates cellular volume homeostasis and is activated by hypotonic solutions. SWELL1, together with four other LRRC8 family members, potentially forms
Autor:
Jennifer M. Kefauver, Gunhee Hong, Wen-Hsin Lee, Zhaozhu Qiu, Jesper Pallesen, Stuart M. Cahalan, Adrienne E. Dubin, Kei Saotome, Andrew B. Ward, Ardem Patapoutian, Christopher A. Cottrell, Christopher S. Crowley, Tess Whitwam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7403c026033d99b26699460fb2d16962
https://doi.org/10.7554/elife.38461.026
https://doi.org/10.7554/elife.38461.026