Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Stuart M. Allan"'
Autor:
Tara A. Gleeson, Christina Kaiser, Catherine B. Lawrence, David Brough, Stuart M. Allan, Jack P. Green
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/35abc22ec05f4cda92c605362d68cc25
Autor:
Kieron South, Lucy Roberts, Anna Gray, Nadim Luka, Patrick Strangward, Graham Coutts, Craig J. Smith, Ingo Schiessl, Stuart M. Allan
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117166- (2024)
Recent investigation of a constitutively active ADAMTS13 variant (caADAMTS13) in murine models of acute ischaemic stroke (AIS) have revealed a potential anti-inflammatory mechanism of action contributing to its protective effect. However, it remains
Externí odkaz:
https://doaj.org/article/6b075d79a3a24b2ba65f6c046add9823
Autor:
Oluwaseun A. Sobowale, Isabel C. Hostettler, Teddy Y. Wu, Calvin Heal, Duncan Wilson, Darshan G. Shah, Daniel Strbian, Jukka Putaala, Turgut Tatlisumak, Andy Vail, Gagan Sharma, Stephen M. Davis, David J. Werring, Atte Meretoja, Stuart M. Allan, Adrian R. Parry-Jones
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundThe relationship between baseline perihematomal edema (PHE) and inflammation, and their impact on survival after intracerebral hemorrhage (ICH) are not well understood.ObjectiveAssess the association between baseline PHE, baseline C-reactiv
Externí odkaz:
https://doaj.org/article/96b76d613e3346df8c8f4fbd97528056
Autor:
Sarah E. Withers, Charlie F. Rowlands, Victor S. Tapia, Frances Hedley, Ioana-Emilia Mosneag, Siobhan Crilly, Gillian I. Rice, Andrew P. Badrock, Andrew Hayes, Stuart M. Allan, Tracy A. Briggs, Paul R. Kasher
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Aicardi-Goutières syndrome (AGS1-9) is a genetically determined encephalopathy that falls under the type I interferonopathy disease class, characterized by excessive type I interferon (IFN-I) activity, coupled with upregulation of IFN-stimulated gen
Externí odkaz:
https://doaj.org/article/21996985323c40e7b3c222331fcef159
Autor:
James Tollitt, Stuart M. Allan, Rajkumar Chinnadurai, Aghogho Odudu, Margaret Hoadley, Craig Smith, Philip A. Kalra
Publikováno v:
BMC Nephrology, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background Chronic kidney disease (CKD) is an independent risk factor for stroke. Stroke is also an independent risk factor for worse CKD outcomes and inflammation may contribute to this bidirectional relationship. This study aims to investi
Externí odkaz:
https://doaj.org/article/193ee4b739e5494992f1b008df01fb30
Autor:
Siobhan Crilly, Adrian Parry-Jones, Xia Wang, Julian N. Selley, James Cook, Victor S. Tapia, Craig S. Anderson, Stuart M. Allan, Paul R. Kasher
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 3 (2022)
Despite the global health burden, treatment of spontaneous intracerebral haemorrhage (ICH) is largely supportive, and translation of specific medical therapies has not been successful. Zebrafish larvae offer a unique platform for drug screening to ra
Externí odkaz:
https://doaj.org/article/3a6cbe4f2e264bf9a3f740c81571b953
Autor:
Catriona J. Cunningham, Raymond Wong, Jack Barrington, Sabrina Tamburrano, Emmanuel Pinteaux, Stuart M. Allan
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2020)
Abstract Background Mesenchymal stem cells (MSCs) hold great potential as a therapy for stroke and have previously been shown to promote recovery in preclinical models of cerebral ischaemia. MSCs secrete a wide range of growth factors, chemokines, cy
Externí odkaz:
https://doaj.org/article/26f6891a49f642bfaeffb57448916fea
Publikováno v:
F1000Research, Vol 8 (2019)
Background: Blockade of the cytokine interleukin-1 (IL-1) with IL-1 receptor antagonist (IL-1Ra) is a candidate treatment for stroke entering phase II/III trials, which acts by inhibiting harmful inflammatory responses. Infection is a common complica
Externí odkaz:
https://doaj.org/article/da9614a3902f4a2fa57d10e8d70a36b6
Autor:
Elena Redondo-Castro, Catriona J. Cunningham, Jonjo Miller, Helena Brown, Stuart M. Allan, Emmanuel Pinteaux
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-11 (2018)
Abstract Background Mesenchymal stem cells (MSCs) are one of the most promising candidates for the treatment of major neurological disorders. Desirable therapeutic properties of MSCs include reparative and regenerative potential but, despite their pr
Externí odkaz:
https://doaj.org/article/310054594d11473fa7ec2015e3889b78
Autor:
Elena Redondo-Castro, Catriona Cunningham, Jonjo Miller, Licia Martuscelli, Sarah Aoulad-Ali, Nancy J. Rothwell, Cay M. Kielty, Stuart M. Allan, Emmanuel Pinteaux
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-11 (2017)
Abstract Background Inflammation is a key contributor to central nervous system (CNS) injury such as stroke, and is a major target for therapeutic intervention. Effective treatments for CNS injuries are limited and applicable to only a minority of pa
Externí odkaz:
https://doaj.org/article/17a516f6e4c24ba9a4a4c740dfdb4cea