Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Stuart M, Levitz"'
Autor:
Charles A. Specht, Ruiying Wang, Lorena V. N. Oliveira, Maureen M. Hester, Christina Gomez, Zhongming Mou, Diana Carlson, Chrono K. Lee, Camaron R. Hole, Woei C. Lam, Rajendra Upadhya, Jennifer K. Lodge, Stuart M. Levitz
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT The global burden of infections due to the pathogenic fungus Cryptococcus is substantial in persons with low CD4+ T-cell counts. Previously, we deleted three chitin deacetylase genes from Cryptococcus neoformans to create a chitosan-deficien
Externí odkaz:
https://doaj.org/article/06a1bf7a6e2243f584d221896bb3e019
Autor:
Ruiying Wang, Lorena V N Oliveira, Maureen M Hester, Diana Carlson, Dennis Christensen, Charles A Specht, Stuart M Levitz
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012220 (2024)
The fungal infection, cryptococcosis, is responsible for >100,000 deaths annually. No licensed vaccines are available. We explored the efficacy and immune responses of subunit cryptococcal vaccines adjuvanted with Cationic Adjuvant Formulation 01 (CA
Externí odkaz:
https://doaj.org/article/f95efdf0739045df975e52daceeaec34
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cryptococcus neoformans and C. gattii, the etiologic agents of cryptococcosis, cause over 100,000 deaths worldwide every year, yet no cryptococcal vaccine has progressed to clinical trials. In preclinical studies, mice vaccinated with an attenuated s
Externí odkaz:
https://doaj.org/article/cd822e4aaf3044ae875264ba6359ba7b
Autor:
Chrono K. Lee, Lorena V. N. Oliveira, Ali Akalin, Charles A. Specht, Diana Lourenco, Christina L. Gomez, Zaida G. Ramirez-Ortiz, Jennifer P. Wang, Stuart M. Levitz
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Inhalation of airborne conidia of the ubiquitous fungus Aspergillus fumigatus commonly occurs but invasive aspergillosis is rare except in profoundly immunocompromised persons. Severe influenza predisposes patients to invasive pulmonary aspe
Externí odkaz:
https://doaj.org/article/623216ce948f4d589b3d3c2221dc2b98
Autor:
Ruiying Wang, Lorena V. N. Oliveira, Diana Lourenco, Christina L. Gomez, Chrono K. Lee, Maureen M. Hester, Zhongming Mou, Gary R. Ostroff, Charles A. Specht, Stuart M. Levitz
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract Vaccination with glucan particles (GP) containing the Cryptococcus neoformans chitin deacetylases Cda1 and Cda2 protect mice against experimental cryptococcosis. Here, immunological correlates of vaccine-mediated protection were explored. St
Externí odkaz:
https://doaj.org/article/2abf535f6ab94b949746239e52eee480
Autor:
Maureen M. Hester, Lorena V. N. Oliveira, Ruiying Wang, Zhongming Mou, Diana Lourenco, Gary R. Ostroff, Charles A. Specht, Stuart M. Levitz
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Meningitis due to the fungal pathogen Cryptococcus neoformans is estimated to cause nearly 200,000 deaths annually, mostly in resource-limited regions. We previously identified cryptococcal protein antigens which, when delivered in glucan particles,
Externí odkaz:
https://doaj.org/article/dd5f51e1e83046fa9dabdc899f222182
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-8 (2021)
Abstract Despite the substantial global burden of human fungal infections, there are no approved fungal vaccines to protect at risk individuals. Here, we review the progress that has been made and the challenges that lie ahead in the quest towards ef
Externí odkaz:
https://doaj.org/article/3533b1cf9858451ca3dd793cf9e1cccc
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1390 (2023)
Glucan particles (GPs) are hollow, porous 3–5 µm microspheres derived from the cell walls of Baker’s yeast (Saccharomyces cerevisiae). Their 1,3-β-glucan outer shell allows for receptor-mediated uptake by macrophages and other phagocytic innate
Externí odkaz:
https://doaj.org/article/4d571a25c09b4c1389e9329789a03181
Autor:
Charles A. Specht, E. Jane Homan, Chrono K. Lee, Zhongming Mou, Christina L. Gomez, Maureen M. Hester, Ambily Abraham, Florentina Rus, Gary R. Ostroff, Stuart M. Levitz
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT The high global burden of cryptococcosis has made development of a protective vaccine a public health priority. We previously demonstrated that a vaccine composed of recombinant Cryptococcus neoformans chitin deacetylase 2 (Cda2) delivered i
Externí odkaz:
https://doaj.org/article/1a6114f4299c4ca8a075e43864d1b9ee
Autor:
Rajendra Upadhya, Woei C. Lam, Camaron R. Hole, Danealle Parchment, Chrono K. Lee, Charles A. Specht, Stuart M. Levitz, Jennifer K. Lodge
Publikováno v:
The Cell Surface, Vol 7, Iss , Pp 100066- (2021)
Chitosan, a deacetylated form of chitin, is required for the virulence of Cryptococcus neoformans. There are three chitin deacetylase genes (CDA) that are essential for chitosan production, and deletion of all three genes results in the absence of ch
Externí odkaz:
https://doaj.org/article/6e8b69ee789c4441b354836b1b93ffaf