Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Stuart M, Brierley"'
Autor:
Melinda A. Kyloh, Timothy J. Hibberd, Joel Castro, Andrea M. Harrington, Lee Travis, Kelsi N. Dodds, Lukasz Wiklendt, Stuart M. Brierley, Vladimir P. Zagorodnyuk, Nick J. Spencer
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
A surgical method in mice can selectively remove dorsal root ganglia (DRG) at specific spinal levels without interfering with other nerves, providing insight on thoracolumbar vs. lumbosacral DRG contributions to pain signalling and behaviour.
Externí odkaz:
https://doaj.org/article/20ee2769ce6845a380e7b6dce4ebdd5a
Autor:
Ashlee Caldwell, Luke Grundy, Andrea M. Harrington, Sonia Garcia-Caraballo, Joel Castro, Nigel W. Bunnett, Stuart M. Brierley
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract The mechanisms underlying chronic bladder conditions such as interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder syndrome (OAB) are incompletely understood. However, targeting specific receptors mediating neuronal sen
Externí odkaz:
https://doaj.org/article/e6c2108661e44edea86c27c271ba7cfa
Autor:
Joel Castro, Andrea M. Harrington, Fariba Chegini, Dusan Matusica, Nick J. Spencer, Stuart M. Brierley, Rainer V. Haberberger, Christine M. Barry
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
IntroductionImproved understanding of vestibulodynia pathophysiology is required to develop appropriately targeted treatments. Established features include vulvovaginal hyperinnervation, increased nociceptive signalling and hypersensitivity. Emerging
Externí odkaz:
https://doaj.org/article/484fadecf34f427ba2c55fc8def1462e
Autor:
James R. Bayrer, Joel Castro, Archana Venkataraman, Kouki K. Touhara, Nathan D. Rossen, Ryan D. Morrie, Jessica Maddern, Aenea Hendry, Kristina N. Braverman, Sonia Garcia-Caraballo, Gudrun Schober, Mariana Brizuela, Fernanda M. Castro Navarro, Carla Bueno-Silva, Holly A. Ingraham, Stuart M. Brierley, David Julius
Publikováno v:
Nature. 616:137-142
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c59a7b1b338d52649ed00b16b6cb4a0
https://doi.org/10.1038/s41586-023-05829-8
https://doi.org/10.1038/s41586-023-05829-8
Autor:
Friederike Uhlig, Luke Grundy, Sonia Garcia-Caraballo, Stuart M. Brierley, Simon J. Foster, David Grundy
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101695- (2020)
Summary: Despite recently established contributions of the intestinal microbiome to human health and disease, our understanding of bacteria-host communication pathways with regard to the gut-brain axis remains limited. Here we provide evidence that i
Externí odkaz:
https://doaj.org/article/deea55593b294d5d80a437c4a4caef38
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Endometriosis is a chronic and debilitating condition affecting ∼10% of women. Endometriosis is characterized by infertility and chronic pelvic pain, yet treatment options remain limited. In many respects this is related to an underlying lack of kn
Externí odkaz:
https://doaj.org/article/6e688b097531459d9687efd3215cbd10
Autor:
Luke Grundy, Ashlee Caldwell, Amanda Lumsden, Ehsan Mohammadi, Gerhard Hannig, Beverley Greenwood Van-Meervald, Stuart M. Brierley
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic urological condition characterised by urinary urgency, frequency and pelvic pain, that significantly impacts the quality of life for ∼5% of women. Bladder sensation is coordinated by
Externí odkaz:
https://doaj.org/article/3ed6b1d2b169425e9c16bf71885169d7
Autor:
Luke Grundy, Cindy Tay, Stewart Christie, Andrea M. Harrington, Joel Castro, Fernanda C. Cardoso, Richard J. Lewis, Vladimir Zagorodnyuk, Stuart M. Brierley
Publikováno v:
Pain. 164:1012-1026
The bladder wall is innervated by a complex network of afferent nerves that detect bladder stretch during filling. Sensory signals, generated in response to distension, are relayed to the spinal cord and brain to evoke physiological and painful sensa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e330f810d45b9ebbba23ee1cb4c5b2
https://doi.org/10.1097/j.pain.0000000000002795
https://doi.org/10.1097/j.pain.0000000000002795
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Despite their seemingly elementary roles, the colon and rectum undertake a variety of key processes to ensure our overall wellbeing. Such processes are coordinated by the transmission of sensory signals from the periphery to the central nervous syste
Externí odkaz:
https://doaj.org/article/49f026be7b6946cda6947a4ec6d5d4a1
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
The bladder is innervated by extrinsic afferents that project into the dorsal horn of the spinal cord, providing sensory input to the micturition centers within the central nervous system. Under normal conditions, the continuous activation of these n
Externí odkaz:
https://doaj.org/article/b5027ff4bf0c4e4ca38b1c4e651d69f6