Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Stuart Linn"'
Publikováno v:
Human Molecular Genetics. 16:1578-1586
Damage-specific DNA-binding (DDB) protein heterodimer has been extensively studied in the context of nucleotide excision repair. However, the smaller subunit, DDB2, is also implicated in tumor suppressor p53-mediated processes, although the precise d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96da28f92a7e436d1f69d6e5cd1bbc2
https://doi.org/10.1093/hmg/ddm107
https://doi.org/10.1093/hmg/ddm107
Autor:
Stuart Linn
Publikováno v:
The Journal of biological chemistry, vol 290, iss 14
In a previous autobiographical sketch for DNA Repair (Linn, S. (2012) Life in the serendipitous lane: excitement and gratification in studying DNA repair. DNA Repair 11, 595-605), I wrote about my involvement in research on mechanisms of DNA repair.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3e92ee213101f82e9d413397de86e1
https://pubmed.ncbi.nlm.nih.gov/25713083
https://pubmed.ncbi.nlm.nih.gov/25713083
Autor:
Stuart Linn, Toshiki Itoh
Publikováno v:
DNA Repair. 4:1457-1462
p21 CDKN1A is a critical regulator of cell cycle progression in response to DNA damage. There are conflicting conclusions as to whether p21 CDKN1A levels increase or decrease after ultraviolet (UV)-irradiation and recently it was even reported to dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a7d6bc07a615a53324d9d20e0902a8
https://doi.org/10.1016/j.dnarep.2005.08.008
https://doi.org/10.1016/j.dnarep.2005.08.008
Publikováno v:
Annual Review of Biochemistry. 73:39-85
▪ Abstract DNA damage is a relatively common event in the life of a cell and may lead to mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular responses that enable the cell either to eliminate or cope with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0646ebe879d95775e9d2849507ef9f8d
https://doi.org/10.1146/annurev.biochem.73.011303.073723
https://doi.org/10.1146/annurev.biochem.73.011303.073723
Publikováno v:
Molecular and Cellular Biology. 23:7540-7553
Tumor suppressor p53 controls cell cycle progression and apoptosis following DNA damage, thus minimizing carcinogenesis. Mutations in the human DDB2 gene generate the E subgroup of xeroderma pigmentosum (XP-E). We report here that XP-E strains are de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b406b3e876fc64a7f56a47c462895a
https://doi.org/10.1128/mcb.23.21.7540-7553.2003
https://doi.org/10.1128/mcb.23.21.7540-7553.2003
Publikováno v:
Journal of Biological Chemistry. 278:42495-42504
DNA is damaged in vivo by the Fenton reaction mediated by Fe2+ and cellular reductants such as NADH, which reduce Fe3+ to Fe2+ and allow the recycling of iron. To study the response of Escherichia coli to such cycling, the activities of several enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c23c0de3c35782b3cc92877d354f8404
https://doi.org/10.1074/jbc.m306251200
https://doi.org/10.1074/jbc.m306251200
Autor:
Mark T. Boyd, Stuart Linn, Dale S. Haines, Nikolina Vlatkovic, Ying Li, Hitomi Asahara, Jill Fuss
Publikováno v:
Nucleic Acids Research. 31:2451-2459
The human DNA polymerase epsilon catalytic subunit consists of a 140-kDa N-terminal domain that contains the catalytic activity and a 120-kDa C-terminal domain that binds to the other subunits and to exogenous peptides, including PCNA and MDM2. We re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea4725c5d0b6305d5aa34d73dabd21cf
https://doi.org/10.1093/nar/gkg342
https://doi.org/10.1093/nar/gkg342
Publikováno v:
Nucleic Acids Research. 31:2323-2332
Aminopurine (2-AP), a fluorescent analog of ade- nine, has been widely used as a probe for local DNA conformation, since excitation and emission charac- teristics and fluoresence lifetimes of 2-AP vary in a sequence-dependent manner within DNA. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa7aae65fa239285d6a978b39fb0003
https://doi.org/10.1093/nar/gkg339
https://doi.org/10.1093/nar/gkg339
Autor:
Hitomi Asahara, Atsushi Kato, Hiromi Yoshida, Yoshiyuki Mizushina, Kengo Sakaguchi, Xianai Xu, Fumio Sugawara, Nobuyuki Kasai, Masaharu Takemura, Naoki Asano, Stuart Linn
Publikováno v:
Biochemical and Biophysical Research Communications. 304:78-85
The pyrrolidine alkaloids mimicking the structures of pentose with nitrogen in the ring are known to be inhibitors of glycosidases. We report here that a compound belonging to this category is an inhibitor of eukaryotic DNA polymerases. Among the eig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49b638d6c594650b48c2b341d301062
https://doi.org/10.1016/s0006-291x(03)00540-0
https://doi.org/10.1016/s0006-291x(03)00540-0
Publikováno v:
Nucleic Acids Research. 31:562-569
The human DDB1 and DDB2 genes encode the 127 and 48 kDa subunits, respectively, of the damage-specific DNA-binding protein (DDB). Mutations in the DDB2 gene have been correlated with the hereditary disease xeroderma pigmentosum group E. We have inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e834e5feb3bf20f8baf509d54db7c097
https://doi.org/10.1093/nar/gkg152
https://doi.org/10.1093/nar/gkg152