Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Stuart L, Rulten"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12613 (2023)
Our understanding of the molecular mechanisms underlying cancer development and evolution have evolved rapidly over recent years, and the variation from one patient to another is now widely recognized. Consequently, one-size-fits-all approaches to th
Externí odkaz:
https://doaj.org/article/275820e1459f43a88e940a7a5dbad0c8
Autor:
Mark J. O'Connor, Alan Lau, Keith W. Caldecott, Niall M.B. Martin, David Rudge, Jos Jonkers, Sven Rottenberg, Marina Pajic, Robert H. Bradbury, Attilla Ting, Bastiaan Evers, Charlotte Knights, Louise Jones, Janneke E. Jaspers, Henry Brown, Rajesh Odedra, Aaron N. Cranston, Stuart L. Rulten, Lenka Oplustil O'Connor
The PARP inhibitor AZD2461 was developed as a next-generation agent following olaparib, the first PARP inhibitor approved for cancer therapy. In BRCA1-deficient mouse models, olaparib resistance predominantly involves overexpression of P-glycoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2109b65c80b64c5dc8e0c07cc7793822
https://doi.org/10.1158/0008-5472.c.6508109
https://doi.org/10.1158/0008-5472.c.6508109
Autor:
Mark J. O'Connor, Alan Lau, Keith W. Caldecott, Niall M.B. Martin, David Rudge, Jos Jonkers, Sven Rottenberg, Marina Pajic, Robert H. Bradbury, Attilla Ting, Bastiaan Evers, Charlotte Knights, Louise Jones, Janneke E. Jaspers, Henry Brown, Rajesh Odedra, Aaron N. Cranston, Stuart L. Rulten, Lenka Oplustil O'Connor
Supplementary materials and methods. Suppl Table 1. MMS combination PF50 cell line assays. Concentration-dependent potentiation of MMS (PF50 ratios). Suppl Table 2. Permeability of AZD2461 and olaparib were assessed. Suppl Table 3. Activity of olapar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730097b7c140c8178ff65dd44a170b76
https://doi.org/10.1158/0008-5472.22410926.v1
https://doi.org/10.1158/0008-5472.22410926.v1
Autor:
Gabrielle J. Grundy, Luis M. Polo, Zhihong Zeng, Stuart L. Rulten, Nicolas C. Hoch, Pathompong Paomephan, Yingqi Xu, Steve M. Sweet, Alan W. Thorne, Antony W. Oliver, Steve J. Matthews, Laurence H. Pearl, Keith W. Caldecott
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of
Externí odkaz:
https://doaj.org/article/f4adc148d44f418d9df058242e7f3bd6
Autor:
Gabrielle J. Grundy, Stuart L. Rulten, Raquel Arribas-Bosacoma, Kathryn Davidson, Zuzanna Kozik, Antony W. Oliver, Laurence H. Pearl, Keith W. Caldecott
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Werner syndrome is a progeroid disease characterised by genetic instability due to mutations to the WRN helicase/exonuclease. Here the authors define a novel Ku binding motif (KBM) and show that two such motifs facilitate the involvement of WRN in DN
Externí odkaz:
https://doaj.org/article/f76baaf3e5cb4dc5b122d503eff9616e
Autor:
Yolanda ePeña-Oliver, Fabiana M Carvalho, Sandra eSanchez-Roige, Erin B Quinlan, Tianye eJia, Tom eWalker-Tilley, Stuart L Rulten, Frances ePearl, Tobias eBanaschewski, Gareth eBarker, Arun eBokde, Christian eBüchel, Patricia eConrod, Herta eFlor, Jürgen eGallinat, Hugh eGaravan, Andreas eHeinz, Penny eGowland, Marie-Laure ePaillere, Tomas ePaus, Marcella eRietschel, Trevor W Robbins, Michael N Smolka, Gunter eSchumann, Dai N Stephens
Publikováno v:
Frontiers in Genetics, Vol 7 (2016)
Impulsivity is associated with a spectrum of psychiatric disorders including drug addiction. To investigate genetic associations with impulsivity and initiation of drug taking, we took a two-step approach. First, we identified genes whose expression
Externí odkaz:
https://doaj.org/article/5bd45d158ef440a6aef3a3b401d9ecbe
Autor:
Julian R. Thorpe, Sabrina Mosaheb, Lida Hashemzadeh-Bonehi, Nigel J. Cairns, John E. Kay, Simon J. Morley, Stuart L. Rulten
Publikováno v:
Neurobiology of Disease, Vol 17, Iss 2, Pp 237-249 (2004)
The peptidyl-prolyl cis–trans isomerase (PPIase) Pin1 modulates the activity of a range of target proteins involved in the cell cycle, transcription, translation, endocytosis, and apoptosis by facilitating dephosphorylation of phosphorylated serine
Externí odkaz:
https://doaj.org/article/6831e948e542486db703bd4ceee72784
Autor:
Niall M. B. Martin, Bastiaan Evers, Charlotte Knights, Janneke E. Jaspers, Jos Jonkers, Attilla Ting, Henry Brown, Keith W. Caldecott, Sven Rottenberg, Rajesh Odedra, Lenka Oplustil O'Connor, Robert Hugh Bradbury, Aaron Cranston, David Alan Rudge, Mark J. O'Connor, Marina Pajic, Louise J. Jones, Alan Lau, Stuart L. Rulten
Publikováno v:
Cancer Research. 76:6084-6094
The PARP inhibitor AZD2461 was developed as a next-generation agent following olaparib, the first PARP inhibitor approved for cancer therapy. In BRCA1-deficient mouse models, olaparib resistance predominantly involves overexpression of P-glycoprotein
Publikováno v:
Journal of Proteome Research. 14:2575-2582
Poly(ADP-ribose) polymerase 3 (PARP3) is a member of the PARP family enzymes which catalyze the ADP-ribosylation of proteins. PARP3 plays an important role in DNA damage repair and mitotic progression. In this study, we identified, using mass spectro
Autor:
Claire Breslin, Zhihong Zeng, Victoria Coulthard, Anastasia Zlatanou, Stuart L. Rulten, Keith W. Caldecott
Publikováno v:
DNA repair. 58
Acylpeptide hydrolase (APEH) deacetylates N-alpha-acetylated peptides and selectively degrades oxidised proteins, but the biochemical pathways that are regulated by this protease are unknown. Here, we identify APEH as a component of the cellular resp