Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Stuart L, Johnson"'
Autor:
Carlos Aguilar, Debbie Williams, Ramakrishna Kurapati, Rasneer S. Bains, Philomena Mburu, Andy Parker, Jackie Williams, Danilo Concas, Hilda Tateossian, Andrew R. Haynes, Gareth Banks, Pratik Vikhe, Ines Heise, Marie Hutchison, Gemma Atkins, Simon Gillard, Becky Starbuck, Simona Oliveri, Andrew Blake, Siddharth Sethi, Saumya Kumar, Tanaya Bardhan, Jing-Yi Jeng, Stuart L. Johnson, Lara F. Corns, Walter Marcotti, Michelle Simon, Sara Wells, Paul K. Potter, Heena V. Lad
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110170- (2024)
Summary: Despite some evidence indicating diverse roles of whirlin in neurons, the functional corollary of whirlin gene function and behavior has not been investigated or broadly characterized. A single nucleotide variant was identified from our rece
Externí odkaz:
https://doaj.org/article/8421d27753b841d7bc0fb0382fdbd3c7
Autor:
Adam J. Carlton, Jing-Yi Jeng, Fiorella C. Grandi, Francesca De Faveri, Ana E. Amariutei, Lara De Tomasi, Andrew O’Connor, Stuart L. Johnson, David N. Furness, Steve D.M. Brown, Federico Ceriani, Michael R. Bowl, Mirna Mustapha, Walter Marcotti
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114025- (2024)
Summary: Type I spiral ganglion neurons (SGNs) convey sound information to the central auditory pathway by forming synapses with inner hair cells (IHCs) in the mammalian cochlea. The molecular mechanisms regulating the formation of the post-synaptic
Externí odkaz:
https://doaj.org/article/003f391f46fe499b876a09eda87c4a9d
Autor:
Jing-Yi Jeng, Adam J. Carlton, Richard J. Goodyear, Colbie Chinowsky, Federico Ceriani, Stuart L. Johnson, Tsung-Chang Sung, Yelena Dayn, Guy P. Richardson, Michael R. Bowl, Steve D.M. Brown, Uri Manor, Walter Marcotti
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 355-370 (2022)
The transduction of acoustic information by hair cells depends upon mechanosensitive stereociliary bundles that project from their apical surface. Mutations or absence of the stereociliary protein EPS8 cause deafness in humans and mice, respectively.
Externí odkaz:
https://doaj.org/article/5942f8bc16104f7a85b0dffab23f1f8b
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The maintenance of balance and gaze relies on the faithful and rapid signaling of head movements to the brain. In mammals, vestibular organs contain two types of sensory hair cells, type-I and type-II, which convert the head motion-induced movement o
Externí odkaz:
https://doaj.org/article/2aff891aadde429182d17127bd35566d
Autor:
Beatriz Lorente-Cánovas, Stephanie Eckrich, Morag A Lewis, Stuart L Johnson, Walter Marcotti, Karen P Steel
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0261530 (2022)
Tasmanian devil (tde) mice are deaf and exhibit circling behaviour. Sensory hair cells of mutants show disorganised hair bundles with abnormally thin stereocilia. The origin of this mutation is the insertion of a transgene which disrupts expression o
Externí odkaz:
https://doaj.org/article/cee86f7ee77649caa32fec15c001cbb2
Autor:
Marco Manca, Piece Yen, Paolo Spaiardi, Giancarlo Russo, Roberta Giunta, Stuart L. Johnson, Walter Marcotti, Sergio Masetto
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Signal transmission by sensory auditory and vestibular hair cells relies upon Ca2+-dependent exocytosis of glutamate. The Ca2+ current in mammalian inner ear hair cells is predominantly carried through CaV1.3 voltage-gated Ca2+ channels. Despite this
Externí odkaz:
https://doaj.org/article/d479e42949604d35a79bf72763bfb463
Publikováno v:
Physiological Reports, Vol 8, Iss 14, Pp n/a-n/a (2020)
Abstract Mature hair cells transduce information over a wide range of stimulus intensities and frequencies for prolonged periods of time. The efficiency of such a demanding task is reflected in the characteristics of exocytosis at their specialized p
Externí odkaz:
https://doaj.org/article/6d87e842511b4a92a20006fd54592928
Autor:
Laura F. Corns, Stuart L. Johnson, Terri Roberts, Kishani M. Ranatunga, Aenea Hendry, Federico Ceriani, Saaid Safieddine, Karen P. Steel, Andy Forge, Christine Petit, David N. Furness, Corné J. Kros, Walter Marcotti
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair ce
Externí odkaz:
https://doaj.org/article/ecfdf3bfbfef42019680748d1efaa1ea
Autor:
Annalisa Buniello, Neil J Ingham, Morag A Lewis, Andreea C Huma, Raquel Martinez‐Vega, Isabel Varela‐Nieto, Gema Vizcay‐Barrena, Roland A Fleck, Oliver Houston, Tanaya Bardhan, Stuart L Johnson, Jacqueline K White, Huijun Yuan, Walter Marcotti, Karen P Steel
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 3, Pp 191-207 (2016)
Abstract WBP2 encodes the WW domain‐binding protein 2 that acts as a transcriptional coactivator for estrogen receptor α (ESR1) and progesterone receptor (PGR). We reported that the loss of Wbp2 expression leads to progressive high‐frequency hea
Externí odkaz:
https://doaj.org/article/0c9669943136495193cd48843b715189
Autor:
Adam J Carlton, Jing‐Yi Jeng, Fiorella C Grandi, Francesca De Faveri, Federico Ceriani, Lara De Tomasi, Anna Underhill, Stuart L Johnson, Kevin P Legan, Corné J Kros, Guy P Richardson, Mirna Mustapha, Walter Marcotti
Publikováno v:
The EMBO Journal. 42