Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Stuart Knechtle"'
Publikováno v:
Frontiers in Transplantation, Vol 2 (2023)
The United States system of solid organ transplantation is overseen by the Organ Procurement Transplantation Network (OPTN). Recent announcements from the Health Resources and Services Administration (HRSA) indicate their clear intention to reform th
Externí odkaz:
https://doaj.org/article/ac83f5dcaa8a46e1b49876408acb63cc
Autor:
Robin Schmitz, Miriam Manook, Zachary Fitch, Imran Anwar, Isabel DeLaura, Danae Olaso, Ashley Choi, Janghoon Yoon, Yeeun Bae, Mingqing Song, Alton B. Farris, Jean Kwun, Stuart Knechtle
Publikováno v:
Frontiers in Transplantation, Vol 2 (2023)
IntroductionOne-third of HLA-incompatible kidney transplant recipients experience antibody mediated rejection (AMR) with limited treatment options. This study describes a novel treatment strategy for AMR consisting of proteasome inhibition and costim
Externí odkaz:
https://doaj.org/article/d6ea67d48a0748f3a4d2932d898a1dee
Autor:
Meixue Duan, Doan C. Nguyen, Chester J. Joyner, Celia L. Saney, Christopher M. Tipton, Joel Andrews, Sagar Lonial, Caroline Kim, Ian Hentenaar, Astrid Kosters, Eliver Ghosn, Annette Jackson, Stuart Knechtle, Stalinraja Maruthamuthu, Sindhu Chandran, Tom Martin, Raja Rajalingam, Flavio Vincenti, Cynthia Breeden, Ignacio Sanz, Greg Gibson, F. Eun-Hyung Lee
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112682- (2023)
Summary: Human bone marrow (BM) plasma cells are heterogeneous, ranging from newly arrived antibody-secreting cells (ASCs) to long-lived plasma cells (LLPCs). We provide single-cell transcriptional resolution of 17,347 BM ASCs from five healthy adult
Externí odkaz:
https://doaj.org/article/e2cfa9f8c92144a5ae6fadda3ba129f7
Publikováno v:
Frontiers in Transplantation, Vol 2 (2023)
Using novel drugs targeting lymphocyte costimulation, cytokines, antibody, complement, and plasma cells, we have developed strategies in a non-human primate model to modulate the B cell response to incompatible kidney transplants. After more than two
Externí odkaz:
https://doaj.org/article/673b054ae55a40e6893b982eeb1536bd
Autor:
Samuel J. Kesseli, Jared N. Gloria, Nader Abraham, Samantha E. Halpern, Greta N. Cywinska, Min Zhang, Dimitrios Moris, Robin Schmitz, Brian I. Shaw, Zachary W. Fitch, Mingqing Song, Cynthia D. Guy, Mathew G Hartwig, Stuart Knechtle, Andrew S. Barbas
Publikováno v:
Hepatology Communications, Vol 5, Iss 9, Pp 1527-1542 (2021)
Normothermic machine perfusion (NMP) provides clinicians an opportunity to assess marginal livers before transplantation. However, objective criteria and point‐of‐care (POC) biomarkers to predict risk and guide decision making are lacking. In thi
Externí odkaz:
https://doaj.org/article/d2501de6355e401196796b4e7d412c7c
Autor:
Miriam Manook, Walter J. Flores, Robin Schmitz, Zachary Fitch, Janghoon Yoon, Yeeun Bae, Brian Shaw, Allan Kirk, Melissa Harnois, Sallie Permar, Alton B. Farris, Diogo M. Magnani, Jean Kwun, Stuart Knechtle
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundIn transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor-specific antibody (DSA), yet both have limitations. We sought to test the efficacy of targeting the IgG recycli
Externí odkaz:
https://doaj.org/article/1f0e067ea29d456693bbacb7f1722d6b
Autor:
Ashley Y. Choi, Miriam Manook, Danae Olaso, Brian Ezekian, Jaeberm Park, Kyle Freischlag, Annette Jackson, Stuart Knechtle, Jean Kwun
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
There is an urgent need for therapeutic interventions for desensitization and antibody-mediated rejection (AMR) in sensitized patients with preformed or de novo donor-specific HLA antibodies (DSA). The risk of AMR and allograft loss in sensitized pat
Externí odkaz:
https://doaj.org/article/6a83d9ff3f7848059a8ddacea87a1d85
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 16, p 3656 (2021)
Patients with previous sensitization events against anti-human leukocyte antigens (HLA) often have circulating anti-HLA antibodies. Following organ transplantation, sensitized patients have higher rates of antibody-mediated rejection (AMR) compared t
Externí odkaz:
https://doaj.org/article/1d343722189646858e8a57f49ae478b1
Autor:
Kyle William Freischlag, BA, Julia Messina, MD, Brian Ezekian, MD, Michael S. Mulvihill, MD, Andrew Barbas, MD, Carl Berg, MD, Debra Sudan, MD, John Reynolds, MD, Matthew Hartwig, MD, Stuart Knechtle, MD
Publikováno v:
Transplantation Direct, Vol 4, Iss 5, p e349 (2018)
Background. Combined lung-liver transplantation (LLT) applies 2 technically challenging transplants in 1 patient with severe 2-organ failure. Methods. Institutional medical records and United Network for Organ Sharing database were queried for patien
Externí odkaz:
https://doaj.org/article/d5b83f9da0dd4972a317b35548b80b56
Autor:
Kazuhito Kawata, Masanobu Tsuda, Guo-Xiang Yang, Weici Zhang, Hajime Tanaka, Koichi Tsuneyama, Patrick Leung, Xiao-Song He, Stuart Knechtle, Aftab A Ansari, Ross L Coppel, M Eric Gershwin
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74225 (2013)
Primary biliary cirrhosis (PBC) is considered a model autoimmune disease, with the most highly directed and specific autoantibody in both murine and human autoimmunity, the anti-mitochondrial autoantibody (AMA). However, therapeutic advances in this
Externí odkaz:
https://doaj.org/article/071b3f16f31142db9ffa468902ca6751