Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Stuart K, Calderwood"'
Autor:
Yuka Okusha, Martin E. Guerrero-Gimenez, Benjamin J. Lang, Thiago J. Borges, Mary A. Stevenson, Andrew W. Truman, Stuart K. Calderwood
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The dynamic network of chaperone interactions known as the chaperome contributes significantly to the proteotoxic cell response and the malignant phenotype. To bypass the inherent redundancy in the network, we have used a microRNA (mir) appr
Externí odkaz:
https://doaj.org/article/08c5c3ecf3294ec38e46e5dccd87122b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5168 (2023)
The cell stress response is an essential system present in every cell for responding and adapting to environmental stimulations. A major program for stress response is the heat shock factor (HSF)–heat shock protein (HSP) system that maintains prote
Externí odkaz:
https://doaj.org/article/d022eeb5e87645d4a3c2786a6951efec
Autor:
Donguk Kim, Na Yeon Park, Keunsoo Kang, Stuart K. Calderwood, Dong-Hyung Cho, Ill Ju Bae, Heeyoun Bunch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Arsenic is reportedly a biphasic inorganic compound for its toxicity and anticancer effects in humans. Recent studies have shown that certain arsenic compounds including arsenic hexoxide (AS4O6; hereafter, AS6) induce programmed cell death a
Externí odkaz:
https://doaj.org/article/13917fef64e648a2b26cd33f38adb295
Autor:
Takanori Eguchi, Eva Csizmadia, Hotaka Kawai, Mona Sheta, Kunihiro Yoshida, Thomas L. Prince, Barbara Wegiel, Stuart K. Calderwood
Publikováno v:
Cells, Vol 11, Iss 24, p 3993 (2022)
Epithelial–mesenchymal transition (EMT) is a reversible cellular program that transiently places epithelial (E) cells into pseudo-mesenchymal (M) cell states. The malignant progression and resistance of many carcinomas depend on EMT activation, par
Externí odkaz:
https://doaj.org/article/d07c6fbc92cd4676a76f634ee71fdddf
Autor:
Heeyoun Bunch, Jaehyeon Jeong, Keunsoo Kang, Doo Sin Jo, Anh T. Q. Cong, Deukyeong Kim, Donguk Kim, Dong-Hyung Cho, You Mie Lee, Benjamin P. C. Chen, Matthew J. Schellenberg, Stuart K. Calderwood
Publikováno v:
Open Biology, Vol 11, Iss 10 (2021)
RNA polymerase II (Pol II)-dependent transcription in stimulus-inducible genes requires topoisomerase IIβ (TOP2B)-mediated DNA strand break and the activation of DNA damage response signalling in humans. Here, we report a novel function of the breas
Externí odkaz:
https://doaj.org/article/6d84432b1b6c4245b6debb21f48be0c7
Publikováno v:
Cell Stress and Chaperones. 28:167-175
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1369110a579fd7033b5fc087cd3d643e
https://doi.org/10.1007/s12192-023-01326-z
https://doi.org/10.1007/s12192-023-01326-z
Autor:
Kisho Ono, Chiharu Sogawa, Hotaka Kawai, Manh Tien Tran, Eman A. Taha, Yanyin Lu, May Wathone Oo, Yuka Okusha, Hirohiko Okamura, Soichiro Ibaragi, Masaharu Takigawa, Ken-Ichi Kozaki, Hitoshi Nagatsuka, Akira Sasaki, Kuniaki Okamoto, Stuart K. Calderwood, Takanori Eguchi
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Evidence has been accumulating to indicate that extracellular vesicles (EVs), including exosomes, released by cancer cells can foster tumour progression. The molecular chaperones – CDC37, HSP90α and HSP90β play key roles in cancer progression inc
Externí odkaz:
https://doaj.org/article/b53c1f3ebc004569af677ed7fa7d9e2a
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Heat shock proteins (HSP) are a highly abundant class of molecular chaperones that can be released into the extracellular milieu and influence the immune response. HSP release can occur when cells undergo necrosis and exude their contents. However, H
Externí odkaz:
https://doaj.org/article/206ec7506e0347f6814ed52b310ee244
Autor:
Thiago J. Borges, Naoka Murakami, Felipe D. Machado, Ayesha Murshid, Benjamin J. Lang, Rafael L. Lopes, Laura M. Bellan, Mayuko Uehara, Krist H. Antunes, Maria José Pérez-Saéz, Gabriel Birrane, Priscila Vianna, João Ismael B. Gonçalves, Rafael F. Zanin, Jamil Azzi, Reza Abdi, Satoshi Ishido, Jeoung-Sook Shin, Ana Paula D. Souza, Stuart K. Calderwood, Leonardo V. Riella, Cristina Bonorino
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Donor-derived dendritic cells (do-DC) in the graft can contribute to the induction of alloimmunity and tissue rejection, but how do-DC can be targeted for improving graft survival is unclear. Here the authors show that reducing MHC-II expression on d
Externí odkaz:
https://doaj.org/article/ead005caa3954154a96d660f0fad15fc
Autor:
Jianlin Gong, Benjamin J. Lang, Desheng Weng, Takanori Eguchi, Ayesha Murshid, Thiago J. Borges, Sachin Doshi, Baizheng Song, Mary A. Stevenson, Stuart K. Calderwood
Publikováno v:
Molecular Oncology, Vol 12, Iss 8, Pp 1249-1263 (2018)
We describe a cell damage‐induced phenotype in mammary carcinoma cells involving acquisition of enhanced migratory and metastatic properties. Induction of this state by radiation required increased activity of the Ptgs2 gene product cyclooxygenase
Externí odkaz:
https://doaj.org/article/1791069ec17b4a3d837dbec84af4d35f