Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Stuart J. Kahn"'
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
Tramadol is widely used globally and is the second most prescribed opioid in the United States. It treats moderate to severe pain but lethal opioid-induced respiratory depression is uncommon even in large overdose. It is unknown why tramadol spares r
Externí odkaz:
https://doaj.org/article/02111778d07a4ee8a972583f7ab1f827
Autor:
David A. Sallman, Amy E. DeZern, Arlene A. Gayle, Stuart J. Kahn, Eric Padron, Jeffrey E. Lancet, Andrew Kuykendall, Kendra Sweet, Onyee Chan, Dean Y. Maeda, Aaron D. Schuler, John A. Zebala, Rami S. Komrokji
Publikováno v:
Blood. 140:2070-2072
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c2982870ad1ba0b866d35677065cc09
https://doi.org/10.1182/blood-2022-159774
https://doi.org/10.1182/blood-2022-159774
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
Frontiers in Pharmacology
Frontiers in Pharmacology
Tramadol is widely used globally and is the second most prescribed opioid in the United States. It treats moderate to severe pain but lethal opioid-induced respiratory depression is uncommon even in large overdose. It is unknown why tramadol spares r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522146044c951b5cbb3329b260f64736
https://www.frontiersin.org/article/10.3389/fphar.2019.01680/full
https://www.frontiersin.org/article/10.3389/fphar.2019.01680/full
Autor:
Dean Y. Maeda, Aaron D. Schuler, Matthew S. Johnson, Shawn L. Searle, John A. Zebala, Stuart J. Kahn, Lynn R. Webster
Publikováno v:
J Pain
Desmetramadol is an investigational analgesic consisting of (+) and (-) enantiomers of the tramadol metabolite O-desmethyltramadol (M1). Tramadol is racemic and exerts analgesia by monoaminergic effects of (-)-tramadol and (-)-M1, and by the opioid (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1db60c8dfd5c9d17cc66d8350da73e
https://pubmed.ncbi.nlm.nih.gov/31005596
https://pubmed.ncbi.nlm.nih.gov/31005596
Autor:
Shawn L. Searle, Stuart J. Kahn, Dean Y. Maeda, John A. Zebala, Lynn R. Webster, Aaron D. Schuler
Publikováno v:
The Journal of Pain. 20:S54
Desmetramadol (INN) is an investigational analgesic consisting of the (+) and (-) enantiomers of the tramadol active M1 metabolite. Tramadol is schedule IV with better safety than schedule II opioids. Tramadol is racemic and exerts analgesia by a mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14fc2f863b3de4e3f11a20606f790afb
https://doi.org/10.1016/j.jpain.2019.01.476
https://doi.org/10.1016/j.jpain.2019.01.476
Autor:
Joel R. Morgan, Lei Wang, Aleem Gangjee, Stuart J. Kahn, Aaron D. Schuler, Breck Thrash, Dean Y. Maeda, Larry H. Matherly, Alan Menter, Christina Cherian, John A. Zebala
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 342:696-708
N-[4-[[(2,4-diamino-6-pterdinyl)methyl]amino]benzoyl]-l/d-glutamic acid (l/d-AMT) is an investigational drug in phase 1 clinical development that consists of the l-and d-enantiomers of aminopterin (AMT). l/d-AMT is obtained from a novel process for m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e631960def7924fbacc3f7353fb09d9b
https://doi.org/10.1124/jpet.112.195479
https://doi.org/10.1124/jpet.112.195479
Autor:
Sonali Trivedi, Vijay K. Rai, Steven G. Reed, Subodh Kumar, Anna Marie Beckmann, Stuart J. Kahn, Karen D. Cowgill, Shyam Sundar, Jaya Chakravarty, Franco M. Piazza, Elsa M. Laughlin, Anup Singh, Rhea N. Coler, Jill A. Ashman
Publikováno v:
Vaccine. 29:3531-3537
Healthy Indian adult volunteers, with or without a history of leishmaniasis, were evaluated for evidence of previous infection with Leishmania donovani based on the direct agglutination test (DAT). Three cohorts of 6 DAT-negative and 6 DAT-positive s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9149ebdea6284d19d9f546c87713149b
https://doi.org/10.1016/j.vaccine.2011.02.096
https://doi.org/10.1016/j.vaccine.2011.02.096
Autor:
Steven G. Reed, Stuart J. Kahn, Karen D. Cowgill, Anna Marie Beckmann, Wessmark Calderon, Elsa M. Laughlin, Lisa Y. Bogatzki, Maria Cruz, Fabiana P. Alves, Rhea N. Coler, Sylvie Bertholet, Jill A. Ashman, Franco M. Piazza, Alejandro Llanos-Cuentas
Publikováno v:
Vaccine. 28:7427-7435
Adult patients with mucosal leishmaniasis (ML) were enrolled in a randomized, double-blind, placebo-controlled, dose-escalating clinical trial and were randomly assigned to receive three injections of either the LEISH-F1+MPL-SE vaccine (consisting of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdcb96157fbb712a382e2517a0341e6e
https://doi.org/10.1016/j.vaccine.2010.08.092
https://doi.org/10.1016/j.vaccine.2010.08.092
Autor:
Anna Marie Beckmann, Stuart J. Kahn, Karen D. Cowgill, Edva P. Vieira, Evaldo Nascimento, Demetrios F. Fernandes, Samuel O. Pine, Rhea N. Coler, Franco M. Piazza, Lisa Y. Bogatzki, Jill A. Ashman, Antonio Campos-Neto, Fabiana P. Alves, Steven G. Reed
Publikováno v:
Vaccine. 28:6581-6587
Forty-four adult patients with cutaneous leishmaniasis (CL) were enrolled in a randomized, double-blind, controlled, dose-escalating clinical trial and were randomly assigned to receive three injections of either the LEISH-F1 + MPL-SE vaccine (consis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b564f7439a7497b97b5bd4632c6fe7ea
https://doi.org/10.1016/j.vaccine.2010.07.063
https://doi.org/10.1016/j.vaccine.2010.07.063
Autor:
Fabiana P. Alves, Lisa Y. Bogatzki, Katherine Gilchrist, Iván D. Vélez, Franco M. Piazza, Sofía Martínez, Steven G. Reed, Anna Marie Beckmann, José R. Ramírez-Pineda, Stuart J. Kahn, Karen D. Cowgill, Rhea N. Coler, Jill A. Ashman
Publikováno v:
Vaccine. 28:329-337
Healthy Colombian adult volunteers with no history of leishmaniasis were evaluated for evidence of previous subclinical infection with Leishmania based on the Montenegro skin test (MST). Twelve MST-positive subjects were enrolled in an open-label, un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e1b23139d1368f3a80f2c92184676f
https://doi.org/10.1016/j.vaccine.2009.10.045
https://doi.org/10.1016/j.vaccine.2009.10.045