Measurement of HNE-protein adducts in human plasma and serum by ELISA—Comparison of two primary antibodies

Autor: Daniela Weber, Lidija Milkovic, Stuart J. Bennett, Helen R. Griffiths, Neven Zarkovic, Tilman Grune

Publikováno v: Redox Biology, Vol 1, Iss 1, Pp 226-233 (2013)

There is increasing evidence that non-enzymatic post-translational protein modifications might play key roles in various diseases. These protein modifications can be caused by free radicals generated during oxidative stress or by their products gener

Externí odkaz: https://doaj.org/article/223b39a5f3414740b7a2207f06ca6c02

Oxidative Stress in Vascular Dementia and Alzheimer's Disease: A Common Pathology

Autor: Stuart J. Bennett, Melissa M. Grant, Sarah Aldred

Publikováno v: Journal of Alzheimer's Disease. 17:245-257

Alzheimer's disease and vascular dementia are the two most common types of dementia with the former being the most predominant. It is evident that oxidative stress, an environment where pro-oxidant species overwhelm antioxidant species, is involved i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa5df2eb4fee4d7c4b5ffd6a7f3a19d
https://doi.org/10.3233/jad-2009-1041

Novel ageing-biomarker discovery using data-intensive technologies

Autor: Christopher R. Dunston, Florence Debacq-Chainiaux, Olivier Toussaint, Santos A. Navarrete, Stuart J. Bennett, Peter Kristensen, Helen R. Griffiths, Andreas Simm, Connie Jenning Melchjorsen, Edyta Augustyniak

Publikováno v: Griffiths, H R, Augustyniak, E M, Bennett, S J, Debacq-Chainiaux, F, Dunston, C R, Kristensen, P, Melchjorsen, C J, Navarrete, S A, Simm, A & Toussaint, O 2015, ' Novel ageing-biomarker discovery using data-intensive technologies ', Mechanisms of Ageing and Development, vol. 151, pp. 114–121 . https://doi.org/10.1016/j.mad.2015.05.010

Ageing is accompanied by many visible characteristics. Other biological and physiological markers are also well-described e.g. loss of circulating sex hormones and increased inflammatory cytokines. Biomarkers for healthy ageing studies are presently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d9da9da6c9412c4f2378f0da839b9c
https://pure.au.dk/portal/da/publications/novel-ageingbiomarker-discovery-using-dataintensive-technologies(fe9866b1-b244-40db-a162-5dd87353f050).html

Ankyrin is the major oxidised protein in erythrocyte membranes from end-stage renal disease patients on chronic haemodialysis and oxidation is decreased by dialysis and vitamin C supplementation

Autor: Slave Dimitrov, Tatjana Ruskovska, Caroline L. R. Brown, Helen R. Griffiths, Stuart J. Bennett, Nikola Kamcev

Chronically haemodialysed end-stage renal disease patients are at high risk of morbidity arising from complications of dialysis, the underlying pathology that has led to renal disease and the complex pathology of chronic kidney disease. Anaemia is co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2037b11bc7377882cd842c2520fcefe1
https://publications.aston.ac.uk/id/eprint/24652/1/Ankyrin_is_the_major_oxidised_protein_in_erythrocyte_membranes.pdf

Does metabolic reprogramming underpin age-associated changes in T cell phenotype and function?

Autor: James Brown, Rita C. Torrão, Helen R. Griffiths, Stuart J. Bennett

Publikováno v: Free radical biologymedicine. 71

T cells are required for an effective adaptive immune response. The principal function of T cells is to promote efficient removal of foreign material by identifying and mounting a specific response to nonself. A decline in T cell function in aging is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd293d105eb5cc01575d5c3d9afc29a8
https://pubmed.ncbi.nlm.nih.gov/24632379