Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Stuart J. Forbes"'
Autor:
Yunxi Gao, Victoria L. Gadd, Maria Heim, Rhiannon Grant, Thomas S. R. Bate, Hannah Esser, Sofia Ferreira Gonzalez, Tak Yung Man, Stuart J. Forbes, Anthony Callanan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Liver disease cases are rapidly expanding worldwide, and transplantation remains the only effective cure for end-stage disease. There is an increasing demand for developing potential drug treatments, and regenerative therapies using in-vitro
Externí odkaz:
https://doaj.org/article/296f78107bb74eb78576ef134603feee
Autor:
Candice Ashmore-Harris, Evangelia Antonopoulou, Rhona E. Aird, Tak Yung Man, Simon M. Finney, Annelijn M. Speel, Wei-Yu Lu, Stuart J. Forbes, Victoria L. Gadd, Sarah L. Waters
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-17 (2024)
Abstract Currently liver transplantation is the only treatment option for liver disease, but organ availability cannot meet patient demand. Alternative regenerative therapies, including cell transplantation, aim to modulate the injured microenvironme
Externí odkaz:
https://doaj.org/article/ae12cbb445934c8a8595557d05d68977
Autor:
Kim Walker, Joanna Moore, Fiona Mitchell, Alison Grant, Christopher J Weir, Ashley Jones, Guruprasad Aithal, Julia Boyd, James W Dear, Aryelly Rodriguez, Julia Grahamslaw, James Coulson, Stuart J Forbes, Angela Thomas, John D M Campbell, Christopher Humphries, Ellise Clarke, Ailsa Geddes, Sharon Zahra, Melisande Addison, Lesley Briody, Maria Elena Candela, Nicholas Downing-James, Robert John Fontana, Anna Heye, James A Hutchinson, Alice Riddell, Garry Tucker, Rachel Woods
Publikováno v:
BMJ Open, Vol 14, Iss 12 (2024)
Introduction Acute liver failure (ALF) has no effective treatment other than liver transplantation and is commonly caused by paracetamol overdose. New treatments are needed to treat and prevent ALF. Alternatively-activated macrophages (AAMs) can prom
Externí odkaz:
https://doaj.org/article/6db0db5e6bff4b63bb8fdd49339ab608
Autor:
Candice Ashmore-Harris, Evangelia Antonopoulou, Simon M. Finney, Melissa R. Vieira, Matthew G. Hennessy, Andreas Muench, Wei-Yu Lu, Victoria L. Gadd, Alicia J. El Haj, Stuart J. Forbes, Sarah L. Waters
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-10 (2024)
Abstract Cell therapies are emerging as promising treatments for a range of liver diseases but translational bottlenecks still remain including: securing and assessing the safe and effective delivery of cells to the disease site; ensuring successful
Externí odkaz:
https://doaj.org/article/ae003db3cf7c435db3b3e580984070d7
Autor:
Zaniah N. Gonzalez Galofre, Alastair M. Kilpatrick, Madalena Marques, Diana Sá da Bandeira, Telma Ventura, Mario Gomez Salazar, Léa Bouilleau, Yvan Marc, Ana B. Barbosa, Fiona Rossi, Mariana Beltran, Harmen J. G. van de Werken, Wilfred F. J. van IJcken, Neil C. Henderson, Stuart J. Forbes, Mihaela Crisan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Hematopoietic stem cells (HSCs) produce all essential cellular components of the blood. Stromal cell lines supporting HSCs follow a vascular smooth muscle cell (vSMC) differentiation pathway, suggesting that some hematopoiesis-supporting cel
Externí odkaz:
https://doaj.org/article/d77d6de51b434aa2a582b339aa96b35c
Autor:
Francesco Bellanti, Giorgia di Bello, Giuseppina Iannelli, Giuseppe Pannone, Maria Carmela Pedicillo, Luke Boulter, Wei-Yu Lu, Rosanna Tamborra, Rosanna Villani, Gianluigi Vendemiale, Stuart J. Forbes, Gaetano Serviddio
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-12 (2021)
Abstract The stem cell ability to self-renew and lead regeneration relies on the balance of complex signals in their microenvironment. The identification of modulators of hepatic progenitor cell (HPC) activation is determinant for liver regeneration
Externí odkaz:
https://doaj.org/article/d61f8bccbb224beb9600090ce80a0056
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Liver disease cases are rapidly expanding across the globe and the only effective cure for end-stage disease is a transplant. Transplant procedures are costly and current supply of donor livers does not satisfy demand. Potential drug treatme
Externí odkaz:
https://doaj.org/article/29039efda635488b91aee81ad2c8b509
Autor:
Nunzia Pastore, Tuong Huynh, Niculin J. Herz, Alessia Calcagni’, Tiemo J. Klisch, Lorenzo Brunetti, Kangho Ho Kim, Marco De Giorgi, Ayrea Hurley, Annamaria Carissimo, Margherita Mutarelli, Niya Aleksieva, Luca D’Orsi, William R. Lagor, David D. Moore, Carmine Settembre, Milton J. Finegold, Stuart J. Forbes, Andrea Ballabio
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The Transcription Factor EB (TFEB) is known to regulate cellular homeostasis and energy metabolism, but its role in cell fate determination in the liver is unknown. Here, the authors show that TFEB regulates the progenitor/cholangiocyte lineage and t
Externí odkaz:
https://doaj.org/article/dac8c6aa736f4598a4966ab084bf32fc
Autor:
Danny Laurent, Fiona Semple, Philip J. Starkey Lewis, Elaine Rose, Holly A. Black, Jennifer Coe, Stuart J. Forbes, Mark J. Arends, James W. Dear, Timothy J. Aitman
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-12 (2020)
Abstract Background Despite the emergence of cell-free DNA (cfDNA) as a clinical biomarker in cancer, the tissue origins of cfDNA in healthy individuals have to date been inferred only by indirect and relative measurement methods, such as tissue-spec
Externí odkaz:
https://doaj.org/article/9401d867436e46d280e980e296abdf7e
Autor:
Iasmim Diniz Orge, Victoria L. Gadd, Judah Leão Barouh, Erik Aranha Rossi, Rejane Hughes Carvalho, Ian Smith, Kyan James Allahdadi, Bruno Diaz Paredes, Daniela Nascimento Silva, Patrícia Kauanna F. Damasceno, Gabriela Louise Sampaio, Stuart J. Forbes, Milena Botelho Pereira Soares, Bruno Solano de Freitas Souza
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-15 (2020)
Abstract Background Hepatocyte-like cells (iHEPs) generated by transcription factor-mediated direct reprogramming of somatic cells have been studied as potential cell sources for the development of novel therapies targeting liver diseases. The mechan
Externí odkaz:
https://doaj.org/article/9ce88985b8a34da1b8f10c15808eaeae