Zobrazeno 1 - 10
of 478
pro vyhledávání: '"Stuart J Spechler"'
Autor:
Colin W Howden, Stuart J Spechler, Christian Atkinson, Michael F Vaezi, Stephen Brunton, A Mark Fendrick, Corey Pelletier, Rinu Jacob
Publikováno v:
BMJ Open Gastroenterology, Vol 9, Iss 1 (2022)
Objective Management of erosive oesophagitis (EE) remains suboptimal, with many patients experiencing incomplete healing, ongoing symptoms, and relapse despite proton pump inhibitor (PPI) treatment. The Study of Acid-Related Disorders investigated pa
Externí odkaz:
https://doaj.org/article/7fbc73b2dc4c493f9abc07011ca45d1d
Autor:
Edaire Cheng, Xi Zhang, Kathleen S Wilson, David H Wang, Jason Y Park, Xiaofang Huo, Chunhua Yu, Qiuyang Zhang, Stuart J Spechler, Rhonda F Souza
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157376 (2016)
Although most studies on treatments for eosinophilic esophagitis (EoE) have focused on effects in the epithelium, EoE is a transmural disease. Eosinophils that infiltrate the subepithelial layers of the esophagus lead to fibrosis and the serious comp
Externí odkaz:
https://doaj.org/article/cddd89b23eb54e8fb74b2526997a8ae3
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101391 (2014)
Besides reducing gastric acid secretion, proton pump inhibitors (PPIs) suppress Th2-cytokine-stimulated expression of an eosinophil chemoattractant (eotaxin-3) by esophageal epithelial cells through acid-independent, anti-inflammatory mechanisms. To
Externí odkaz:
https://doaj.org/article/f84ef3cb5a624ddd84a100b056f8735f
Autor:
Xi Zhang, Edaire Cheng, Xiaofang Huo, Chunhua Yu, Qiuyang Zhang, Thai H Pham, David H Wang, Stuart J Spechler, Rhonda F Souza
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50037 (2012)
Patients who have esophageal eosinophilia without gastroesophageal reflux disease (GERD) nevertheless can respond to proton pump inhibitors (PPIs), which can have anti-inflammatory actions independent of effects on gastric acid secretion. In esophage
Externí odkaz:
https://doaj.org/article/ddea688dca2b4eeeb85de10b072f1f7f
Autor:
Xi Zhang, Chunhua Yu, Kathleen Wilson, Hui Ying Zhang, Shelby D Melton, Xiaofang Huo, David H Wang, Robert M Genta, Stuart J Spechler, Rhonda F Souza
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
Human Barrett's cancer cell lines have numerous, poorly-characterized genetic abnormalities and, consequently, those lines have limited utility as models for studying the early molecular events in carcinogenesis. Cell lines with well-defined genetic
Externí odkaz:
https://doaj.org/article/a3b7b9ae06e0436c9d87edad1f43b4e1
Autor:
Chin Hur, Tristan J Hayeck, Jennifer M Yeh, Ethan M Richards, Stuart J Spechler, G Scott Gazelle, Chung Yin Kong
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9483 (2010)
The incidence of esophageal adenocarcinoma (EAC) has risen rapidly in the U.S. and western world. The aim of the study was to begin the investigation of this rapid rise by developing, calibrating, and validating a mathematical disease simulation mode
Externí odkaz:
https://doaj.org/article/dbc807415c6f4988ad9d7c79fed55bd6
Autor:
Colin W. Howden, Stuart J. Spechler, Michael F. Vaezi, A. Mark Fendrick, Christian Atkinson, Corey Pelletier, Rinu Jacob, Stephen Brunton
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 2, Pp 231-240 (2022)
Background and Aims: Helicobacter pylori eradication rates have declined as antibiotic resistance rates have increased. In addition, adherence to treatment guidelines is suboptimal. It is therefore important that contemporary, real-world evidence of
Externí odkaz:
https://doaj.org/article/39375afa12d14f2dae5434725d2f863a
Autor:
Rhonda F. Souza, Stuart J. Spechler
Publikováno v:
Nature Reviews Gastroenterology & Hepatology. 19:605-620
Autor:
Joan W Chen, Abraham Khan, Reena V Chokshi, John O Clarke, Ronnie Fass, Jose M Garza, Milli Gupta, C Prakash Gyawali, Anand S Jain, Philip Katz, Vani Konda, Adriana Lazarescu, Kristle L Lynch, Felice Schnoll-Sussman, Stuart J Spechler, Marcelo F Vela, Rena Yadlapati, Jacob M Schauer, Peter J Kahrilas, John E Pandolfino, Dustin A Carlson
Publikováno v:
American Journal of Gastroenterology.
Autor:
Benjamin R. Chebaa, Brandon Burgman, Andrew D. Smith, Daniel S. Kim, Tisha Lunsford, Miriam Mara, Leon Kundrotas, Kerry B. Dunbar, Stuart J. Spechler, S. Stephen Yi, Linda A. Feagins
Publikováno v:
Digestive Diseases and Sciences. 67:3210-3219