Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Stuart J Rabin"'
Autor:
Ryan T. Libby, Stuart J Rabin, Ruth Wang, Elaine Pirie, Ranjan Batra, Florian Krach, Anthony Q. Vu, Zacharias Kohl, John Ravits, Gene W. Yeo, Emily C. Wheeler, Michael Baughn, Kasey R. Hutt, María Jesús Delgado Rodríguez, Sandra Diaz-Garcia, Jennifer E. Stauffer, Shahram Saberi, Beate Winner, Assael A. Madrigal
Publikováno v:
Acta neuropathologica, vol 136, iss 3
Sporadic amyotrophic lateral sclerosis (sALS) is the most common form of ALS, however, the molecular mechanisms underlying cellular damage and motor neuron degeneration remain elusive. To identify molecular signatures of sALS we performed genome-wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c8524fa972a3775420f809cbfd797a
https://doi.org/10.1007/s00401-018-1870-7
https://doi.org/10.1007/s00401-018-1870-7
Autor:
Randell T. Libby, Ryan T. Libby, Albert R. La Spada, Jae Mun ‘Hugo’ Kim, Michael Baughn, Stuart J Rabin, Yuxin Fan, Brad Stone, Young Joo Kim, John Ravits
Publikováno v:
Human Molecular Genetics
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive weakness from loss of motor neurons. The fundamental pathogenic mechanisms are unknown and recent evidence is implicating a significant role for abn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe14cb9c2ea7c0d1c98b573ff9f70469
https://doi.org/10.1093/hmg/ddp498
https://doi.org/10.1093/hmg/ddp498
Publikováno v:
Journal of Biological Chemistry. 277:49466-49472
We used NIH-3T3 fibroblasts expressing the different Trk receptors to examine whether GM1 ganglioside and its semisynthetic derivative LIGA20 activate various neurotrophin receptors. GM1 induced autophosphorylation of TrkC more potently than TrkA or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787f58babfa6c4dd9066747a614e3fc6
https://doi.org/10.1074/jbc.m203240200
https://doi.org/10.1074/jbc.m203240200
Publikováno v:
Neurotoxicity Research. 4:225-234
Gangliosides protect cerebellar granule cells from excitotoxicity; however, their mechanism of action remains to be fully characterized. GM1 ganglioside has been shown to activate Trk, the tyrosine kinase receptor implicated in the neuroprotective pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980aa2f45d87ce70db63f945c1bae864
https://doi.org/10.1080/10298420290015836
https://doi.org/10.1080/10298420290015836
Publikováno v:
The Journal of Neuroscience. 18:9326-9334
Glucocorticoid hormones influence neuronal plasticity during development; however little is known about the mechanisms of this trophic activity. Because glucocorticoids increase nerve growth factor (NGF) synthesis in selected brain areas and NGF play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac71e78bb08e2d227ee39e2a54578726
https://doi.org/10.1523/jneurosci.18-22-09326.1998
https://doi.org/10.1523/jneurosci.18-22-09326.1998
Publikováno v:
Journal of Biological Chemistry. 273:29394-29399
The molecular mechanism(s) ofN-methyl-d-aspartate (NMDA) neuroprotective properties were investigated in primary cultures of cerebellar granule cell neurons. Granule cells express the neurotrophin receptor TrkB but not TrkA or TrkC. In these cells, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c04b2b56206ea4cc0e59a53acead00
https://doi.org/10.1074/jbc.273.45.29394
https://doi.org/10.1074/jbc.273.45.29394
Publikováno v:
Molecular Brain Research. 56:273-276
Nerve growth factor (NGF) acts as an anti-mitogenic factor in C6-2B glioma cells stably expressing TrkA (C6trk+). To study the effect of TrkA on cell growth in vivo, we grafted mock and C6trk+ cells into the striatum of ACI nude rats. Thy 1.1 and p75
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e68de2dab9eec04fc268df50c6d1151
https://doi.org/10.1016/s0169-328x(98)00020-5
https://doi.org/10.1016/s0169-328x(98)00020-5
Autor:
Italo Mocchetti, Stuart J. Rabin, Jean R. Wrathall, Scott R. Whittemore, Anna Maria Colangelo
Publikováno v:
Experimental Neurology. 141:154-164
Neurotrophic factors appear to be crucial for the survival and potential regeneration of injured neurons. We have previously demonstrated that contusive spinal cord injury (SCI) increases the levels of mRNA for basic fibroblast growth factor (FGF2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59dfe8ffb826adcc8594d6a147b2e5e
https://doi.org/10.1006/exnr.1996.0149
https://doi.org/10.1006/exnr.1996.0149
Publikováno v:
The Journal of Neuroscience. 14:1542-1554
The response of brain tissue to neurotrophins during rat development was examined using a novel in vitro assay for Trk/neurotrophin receptor activity. In this assay, brain tissues were exposed to neutrophins and ligand-induced Trk tyrosine phosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26119c0a72d6d92ff1645a81d0a03cd1
https://doi.org/10.1523/jneurosci.14-03-01542.1994
https://doi.org/10.1523/jneurosci.14-03-01542.1994
Autor:
Hans Rudolf Widmer, Franz Hefti, David L. Kaplan, Beat Knusel, Klaus D. Beck, Stuart J. Rabin
Publikováno v:
Journal of Neurochemistry. 60:2111-2123
Phospholipase C gamma 1 (PLC-gamma 1) is involved at an early step in signal transduction of many hormones and growth factors and catalyzes the hydrolysis of phosphatidylinositol (PI) 4,5-bisphosphate to diacylglycerol and inositol trisphosphate, two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec7084ca4f8c464a529086700468258
https://doi.org/10.1111/j.1471-4159.1993.tb03496.x
https://doi.org/10.1111/j.1471-4159.1993.tb03496.x