Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Stuart J McDonald"'
Autor:
Sandy R Shultz, Caroline J Taylor, Riemke Aggio-Bruce, William T O’Brien, Mujun Sun, Adrian V Cioanca, George Neocleous, Georgia F Symons, Rhys D Brady, Anandwardhan A Hardikar, Mugdha V Joglekar, Daniel M Costello, Terence J O’Brien, Riccardo Natoli, Stuart J McDonald
Publikováno v:
Biomarker Insights, Vol 17 (2022)
Introduction: Sports-related concussion (SRC) is a common form of brain injury that lacks reliable methods to guide clinical decisions. MicroRNAs (miRNAs) can influence biological processes involved in SRC, and measurement of miRNAs in biological flu
Externí odkaz:
https://doaj.org/article/6e5d1e47e8f3487faaf1d38c5e9fd355
Autor:
Ker Rui Wong, William T O’Brien, Mujun Sun, Glenn Yamakawa, Terence J O’Brien, Richelle Mychasiuk, Sandy R Shultz, Stuart J McDonald, Rhys D Brady
Publikováno v:
Biomarker Insights, Vol 16 (2021)
Introduction: Serum neurofilament light (NfL) is an emerging biomarker of traumatic brain injury (TBI). However, the effect of peripheral injuries such as long bone fracture and skeletal muscle injury on serum NfL levels is unknown. Therefore, the ai
Externí odkaz:
https://doaj.org/article/28958bc4c5ce4401a11c422960c37ffe
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 4, Pp 989-999 (2024)
Abstract Objective Huntington's disease (HD) is an inherited neurodegenerative disease involving progressive motor abnormalities, cognitive decline, and psychiatric disturbances. Depression and cognitive difficulties are among the most impactful symp
Externí odkaz:
https://doaj.org/article/871d1e7b69a6439a97efe08a56f4b870
Autor:
Lauren P. Giesler, William T. O'Brien, Georgia F. Symons, Sabrina Salberg, Gershon Spitz, Robb Wesselingh, Terence J. O'Brien, Richelle Mychasiuk, Sandy R. Shultz, Stuart J. McDonald
Publikováno v:
Neurotrauma Reports, Vol 5, Iss 1, Pp 74-80 (2024)
Traumatic brain injuries (TBIs) and concussions are prevalent in collision sports, and there is evidence that levels of exposure to such sports may increase the risk of neurological abnormalities. Elevated levels of fluid-based biomarkers have been o
Externí odkaz:
https://doaj.org/article/12b7caa5a7f249388a0e051cc18bdca7
Autor:
Tamara L. Baker, David K. Wright, Alessandro D. Uboldi, Christopher J. Tonkin, Anh Vo, Trevor Wilson, Stuart J. McDonald, Richelle Mychasiuk, Bridgette D. Semple, Mujun Sun, Sandy R. Shultz
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-31 (2024)
Abstract Traumatic brain injury (TBI) is a key contributor to global morbidity that lacks effective treatments. Microbial infections are common in TBI patients, and their presence could modify the physiological response to TBI. It is estimated that o
Externí odkaz:
https://doaj.org/article/dd19e4fc213b4406a1fdbe90f4f928eb
Autor:
Josh Allen, Louise Pham, Simon T. Bond, William T. O’Brien, Gershon Spitz, Sandy R. Shultz, Brian G. Drew, David K. Wright, Stuart J. McDonald
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionMild traumatic brain injuries (mTBIs) are the most common form of acquired brain injury. Symptoms of mTBI are thought to be associated with a neuropathological cascade, potentially involving the dysregulation of neurometabolites, lipids,
Externí odkaz:
https://doaj.org/article/7adb297148da47d298204a3936049e59
Autor:
Tamara L. Baker, Alessandro D. Uboldi, Christopher J. Tonkin, David K. Wright, Anh Vo, Trevor Wilson, Richelle Mychasiuk, Stuart J. McDonald, Bridgette D. Semple, Mujun Sun, Sandy R. Shultz
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2023)
IntroductionPost-traumatic epilepsy (PTE) is a debilitating chronic outcome of traumatic brain injury (TBI), and neuroinflammation is implicated in increased seizure susceptibility and epileptogenesis. However, how common clinical factors, such as in
Externí odkaz:
https://doaj.org/article/4592529e97cd40d78e368d66a3902479
Autor:
Rhys D. Brady, Stefanie Bird, Mujun Sun, Glenn R. Yamakawa, Brendan P. Major, Richelle Mychasiuk, Terence J. O'Brien, Stuart J. McDonald, Sandy R. Shultz
Publikováno v:
Neurotrauma Reports, Vol 2, Iss 1, Pp 330-342 (2021)
Neurodegeneration after traumatic brain injury (TBI) is increasingly recognized as a key factor contributing to poor chronic outcomes. Activation (i.e., phosphorylation) of the protein kinase R-like endoplasmic reticulum kinase (PERK) pathway has bee
Externí odkaz:
https://doaj.org/article/d42263c43b084e5d849bcdded32346bd
Autor:
Stefan Piantella, William T. O'Brien, Matthew W. Hale, Paul Maruff, Stuart J. McDonald, Bradley J. Wright
Publikováno v:
Comprehensive Psychoneuroendocrinology, Vol 10, Iss , Pp 100131- (2022)
Jockeys work in high-risk environments that rely heavily on attention- and decision-making to perform well and safely. Workplace stress literature has often overlooked the impact of stress on cognition, and designs that include physiological measures
Externí odkaz:
https://doaj.org/article/fff6b85beabc4568af9fd19bf2c099bf
Autor:
William T. O’Brien, Louise Pham, Georgia F. Symons, Mastura Monif, Sandy R. Shultz, Stuart J. McDonald
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract There is a great clinical need to identify the underlying mechanisms, as well as related biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a central pathophysiological feature of TBI. NLRP3 inflammasom
Externí odkaz:
https://doaj.org/article/a1bb0c6461bd448c8601bfbb5729f59a