Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Stuart J John Hirst"'
2
Heparin and structurally related polymers attenuate eotaxin-1 (CCL11) release from human airway smooth muscle
Autor: Brian J. O'Connor, David E. Simcock, Katharina Mahn, Varsha Kanabar, Stuart J John Hirst, Clive P. Page, Charlotta Karner
Publikováno v: British Journal of Pharmacology. 154:833-842
Background and purpose: The glycosaminoglycan heparin has anti-inflammatory activity and is exclusively found in mast cells, which are localized within airway smooth muscle (ASM) bundles of asthmatic airways. Interleukin (IL)-13 induces the productio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72e396d5a44db331206d9a88bad3527d
https://doi.org/10.1038/bjp.2008.109
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3
Proangiogenic Activity in Bronchoalveolar Lavage Fluid from Patients with Asthma
Autor: Graham W. Clarke, Stuart J John Hirst, Tak H. Lee, David E. Simcock, Brian J. O'Connor, Varsha Kanabar
Publikováno v: American Journal of Respiratory and Critical Care Medicine. 176:146-153
Asthmatic airways have an increased number and size of vascular structures, which contribute to airflow obstruction and hyperresponsiveness.We examined whether proangiogenic mediators are elevated in bronchoalveolar lavage fluid (BALF) from subjects
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36706f5521244e22898072509e624712
https://doi.org/10.1164/rccm.200701-042oc
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4
Repeated Allergen Inhalation Induces Cytoskeletal Remodeling in Smooth Muscle from Rat Bronchioles
Autor: K. Fan Chung, Varsha Kanabar, Katharina Mahn, Stuart J John Hirst, Lyn M Moir, Clare G. McVicker, Sum-Yee Leung
Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 36:721-727
Airway hyperresponsiveness (AHR) is associated with airway wall structural remodeling and alterations in airway smooth muscle (ASM) function. Previously, in bronchioles from Brown Norway rats challenged by repeated ovalbumin (OVA) inhalation, we have
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7075b3e9d5f286930c9c07cce9db92f8
https://doi.org/10.1165/rcmb.2006-0409oc
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5
Some structural determinants of the antiproliferative effect of heparin-like molecules on human airway smooth muscle
Autor: Varsha Kanabar, Brian J. O'Connor, Stuart J John Hirst, Clive P. Page
Publikováno v: British Journal of Pharmacology. 146:370-377
Accumulation of airway smooth muscle (ASM) and its infiltration by mast cells are key pathological features of airway remodelling in asthma. Heparin, a major component of mast cell granules, inhibits ASM proliferation by an unknown mechanism. Here, u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0af7542a9c9815a34106a0906abc001a
https://doi.org/10.1038/sj.bjp.0706333
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6
Multiple β1 Integrins Mediate Enhancement of Human Airway Smooth Muscle Cytokine Secretion by Fibronectin and Type I Collagen
Autor: Qi Peng, Stuart J John Hirst, Takeshi Matsuda, Dilys Lai, Vivien Chan, Trang T-B Nguyen
Publikováno v: The Journal of Immunology. 174:2258-2264
Altered airway smooth muscle (ASM) function and enrichment of the extracellular matrix (ECM) with interstitial collagen and fibronectin are major pathological features of airway remodeling in asthma. We have previously shown that these ECM components
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8c7dc9c45a6a654494206148ea5fed
https://doi.org/10.4049/jimmunol.174.4.2258
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8
Proliferative aspects of airway smooth muscle
Autor: Qutayba Hamid, Elizabeth D. Fixman, Qi Peng, David Ramos-Barbón, Stuart J John Hirst, James G. Martin, Alastair G. Stewart, Clare G. McVicker, John V Bonacci, Lyn M Moir, Jean-Pierre Lavoie, Vivien Chan, Berenice Herszberg, Trang T-B Nguyen
Publikováno v: Journal of Allergy and Clinical Immunology. 114:S2-S17
Increased airway smooth muscle (ASM) mass is perhaps the most important component of the airway wall remodeling process in asthma. Known mediators of ASM proliferation in cell culture models fall into 2 categories: those that activate receptors with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51fbeaccf0f7f29e1da78d17fbb99b3
https://doi.org/10.1016/j.jaci.2004.04.039
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9
Regulation of airway smooth muscle cell immunomodulatory function: role in asthma
Autor: Stuart J John Hirst
Publikováno v: Respiratory Physiology & Neurobiology. 137:309-326
General agreement exists that in asthma, airway smooth muscle contracts, narrowing the airway lumen and thereby causing airflow obstruction and dyspnoea. New evidence is emerging that airway smooth muscle may also fulfil an immunomodulatory role by p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde90542056dfdc0d88d2a482545c1c4
https://doi.org/10.1016/s1569-9048(03)00155-1
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10
Repeated allergen inhalation induces phenotypic modulation of smooth muscle in bronchioles of sensitized rats
Autor: Jeremy P.T. Ward, Clare G. McVicker, Paul R. Eynott, Lyn M Moir, K. Fan Chung, Stuart J John Hirst, Sum-Yee Leung
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 284:L148-L159
Repeated ovalbumin (OA) or saline exposure of sensitized Brown Norway rats was examined on agonist reactivity, airway smooth muscle (ASM) content, and contractile protein expression in small bronchioles at 24 h, 7 days, and 35 days after challenge. O
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611ed3774f008cc3b7b1b4879c87438e
https://doi.org/10.1152/ajplung.00105.2002
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