Identification of a pre-active conformation of a pentameric channel receptor

Autor: Anaïs Menny, Solène N Lefebvre, Philipp AM Schmidpeter, Emmanuelle Drège, Zaineb Fourati, Marc Delarue, Stuart J Edelstein, Crina M Nimigean, Delphine Joseph, Pierre-Jean Corringer

Publikováno v: eLife, Vol 6 (2017)

Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical signaling through global allosteric transitions. Despite the existence of several high-resolution structures of pLGICs, their dynamical properties remain elusive. Using the proton-ga

Externí odkaz: https://doaj.org/article/5a8e01664d3d46f19fbee713e5512e76

Ligand-dependent opening of the multiple AMPA receptor conductance states: a concerted model.

Autor: Ranjita Dutta-Roy, Christian Rosenmund, Stuart J Edelstein, Nicolas Le Novère

Publikováno v: PLoS ONE, Vol 10, Iss 1, p e0116616 (2015)

Modulation of the properties of AMPA receptors at the post-synaptic membrane is one of the main suggested mechanisms underlying fast synaptic transmission in the central nervous system of vertebrates. Electrophysiological recordings of single channel

Externí odkaz: https://doaj.org/article/fba8d16c57794d3e9af6405ce963aece

Neurogranin Stimulates Ca2+/calmodulin-dependent Kinase II by Inhibiting Calcineurin at Specific Calcium Spike Frequencies

Autor: Stewart T. Cole, Stuart J. Edelstein, N. Le Novere, Massimo Lai, Lu Li

Calmodulin sits at the centre of molecular mechanisms underlying learning and memory. Its complex, and sometimes opposite influences, via the binding to various proteins, are yet to be fully understood. Calcium/calmodulin-dependent protein kinase II

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f32918480eb6ca4cc693e13dfeb563
https://doi.org/10.1101/597278

Identification of a pre-active conformation of a pentameric channel receptor

Autor: Solène N Lefebvre, Philipp A. M. Schmidpeter, Stuart J. Edelstein, Zaineb Fourati, Crina M. Nimigean, Emmanuelle Drège, Pierre-Jean Corringer, Anaïs Menny, Delphine Joseph, Marc Delarue

Publikováno v: eLife
eLife, eLife Sciences Publication, 2017, 6, pp.e23955. ⟨10.7554/eLife.23955⟩
eLife, Vol 6 (2017)
eLife, 2017, 6, pp.e23955. ⟨10.7554/eLife.23955⟩

Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical signaling through global allosteric transitions. Despite the existence of several high-resolution structures of pLGICs, their dynamical properties remain elusive. Using the proton-ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc1a6b98fc71833a67d0c1babd952c2
https://doi.org/10.7554/elife.23955

A Novel Equation for Cooperativity of the Allosteric State Function

Autor: Stuart J. Edelstein

Publikováno v: Journal of Molecular Biology

The MWC (Monod–Wyman–Changeux) allosteric model postulates concerted conformational changes between two states: the intrinsically more stable T state with relatively weak ligand binding and the R state with relatively strong ligand binding. The m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2ddc23ae0d05c5400650e834820f4b
https://doi.org/10.1016/j.jmb.2013.09.010