Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Stuart J D, Neil"'
Autor:
Rui Pedro Galão, Harry Wilson, Kristina L Schierhorn, Franka Debeljak, Bianca S Bodmer, Daniel Goldhill, Thomas Hoenen, Sam J Wilson, Chad M Swanson, Stuart J D Neil
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010530 (2022)
Ebola virus (EBOV) causes highly pathogenic disease in primates. Through screening a library of human interferon-stimulated genes (ISGs), we identified TRIM25 as a potent inhibitor of EBOV transcription-and-replication-competent virus-like particle (
Externí odkaz:
https://doaj.org/article/34a54108f0ea4e32a9ec38404b2b6055
Autor:
Hataf Khan, Helena Winstone, Jose M Jimenez-Guardeño, Carl Graham, Katie J Doores, Caroline Goujon, David A Matthews, Andrew D Davidson, Suzannah J Rihn, Massimo Palmarini, Stuart J D Neil, Michael H Malim
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1009820 (2021)
Interferons play a critical role in regulating host immune responses to SARS-CoV-2, but the interferon (IFN)-stimulated gene (ISG) effectors that inhibit SARS-CoV-2 are not well characterized. The IFN-inducible short isoform of human nuclear receptor
Externí odkaz:
https://doaj.org/article/cc928219677448eabb1717d19393c336
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009726 (2021)
The zinc finger antiviral protein (ZAP) is a broad inhibitor of virus replication. Its best-characterized function is to bind CpG dinucleotides present in viral RNAs and, through the recruitment of TRIM25, KHNYN and other cofactors, target them for d
Externí odkaz:
https://doaj.org/article/3921d48fb14042fe8c66e8bbe29e190d
Autor:
Suzanne Pickering, PhD, Rahul Batra, MD, Blair Merrick, MBChB, Luke B Snell, MBBS, Gaia Nebbia, FRCPath, Sam Douthwaite, MRCP, Fiona Reid, MSc, Amita Patel, BSc, Mark Tan Kia Ik, BSc, Bindi Patel, BSc, Themoula Charalampous, PhD, Adela Alcolea-Medina, MPhil, Maria Jose Lista, PhD, Penelope R Cliff, PhD, Emma Cunningham, MSc, Jane Mullen, BSc, Katie J Doores, PhD, Jonathan D Edgeworth, ProfFRCPath, Michael H Malim, ProfDPhil, Stuart J D Neil, ProfPhD, Rui Pedro Galão, PhD
Publikováno v:
The Lancet Microbe, Vol 2, Iss 9, Pp e461-e471 (2021)
Summary: Background: Lateral flow devices (LFDs) for rapid antigen testing are set to become a cornerstone of SARS-CoV-2 mass community testing, although their reduced sensitivity compared with PCR has raised questions of how well they identify infec
Externí odkaz:
https://doaj.org/article/53b1e2b53fca40629950d528d1c01f7f
Autor:
Nicola Sweeney, Blair Merrick, Rui Pedro Galão, Suzanne Pickering, Alina Botgros, Harry D Wilson, Adrian W Signell, Gilberto Betancor, Mark Kia Ik Tan, John Ramble, Neophytos Kouphou, Sam Acors, Carl Graham, Jeffrey Seow, Eithne MacMahon, Stuart J D Neil, Michael H Malim, Katie Doores, Sam Douthwaite, Rahul Batra, Gaia Nebbia, Jonathan D Edgeworth
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249791 (2021)
During the first wave of the global COVID-19 pandemic the clinical utility and indications for SARS-CoV-2 serological testing were not clearly defined. The urgency to deploy serological assays required rapid evaluation of their performance characteri
Externí odkaz:
https://doaj.org/article/2e399c613b574b219ea8a3ec333a2c1b
Autor:
Rayhane Nchioua, Dorota Kmiec, Janis A. Müller, Carina Conzelmann, Rüdiger Groß, Chad M. Swanson, Stuart J. D. Neil, Steffen Stenger, Daniel Sauter, Jan Münch, Konstantin M. J. Sparrer, Frank Kirchhoff
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Recent evidence shows that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is sensitive to interferons (IFNs). However, the most effective types of IFNs and the underlying antiviral effectors remain to be defined. Here, we show
Externí odkaz:
https://doaj.org/article/ce8641cdf3aa423a894bfbb5ce1d791c
Autor:
Suzanne Pickering, Gilberto Betancor, Rui Pedro Galão, Blair Merrick, Adrian W Signell, Harry D Wilson, Mark Tan Kia Ik, Jeffrey Seow, Carl Graham, Sam Acors, Neophytos Kouphou, Kathryn J A Steel, Oliver Hemmings, Amita Patel, Gaia Nebbia, Sam Douthwaite, Lorcan O'Connell, Jakub Luptak, Laura E McCoy, Philip Brouwer, Marit J van Gils, Rogier W Sanders, Rocio Martinez Nunez, Karen Bisnauthsing, Geraldine O'Hara, Eithne MacMahon, Rahul Batra, Michael H Malim, Stuart J D Neil, Katie J Doores, Jonathan D Edgeworth
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008817 (2020)
There is a clear requirement for an accurate SARS-CoV-2 antibody test, both as a complement to existing diagnostic capabilities and for determining community seroprevalence. We therefore evaluated the performance of a variety of antibody testing tech
Externí odkaz:
https://doaj.org/article/9e47f97b555e4d8f826354c685f40001
Autor:
Jonathan D. Edgeworth, Rahul Batra, Gaia Nebbia, Karen Bisnauthsing, Eithne MacMahon, Malur Sudhanva, Sam Douthwaite, Simon Goldenberg, Geraldine O’Hara, Manu Shankar-Hari, Katie J. Doores, Rocio Martinez-Nunez, Carolyn Hemsley, Nicholas M. Price, Jill Lockett, Robert I. Lechler, Stuart J. D. Neil, Michael H. Malim, Carolyn B. Coyne
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9 (2020)
Externí odkaz:
https://doaj.org/article/267de135fcda4e588444060c1f323993
Autor:
Luke B Snell, Adela Alcolea-Medina, Themoula Charalampous, Christopher Alder, Tom G S Williams, Flavia Flaviani, Rahul Batra, Prijay Bakrania, Rajeni Thangarajah, Stuart J D Neil, Claire van Nispen tot Pannerden, Alina Botgros, Emma Aarons, Samuel T Douthwaite, Jonathan D Edgeworth, Gaia Nebbia
Publikováno v:
Clinical Infectious Diseases. 76:1125-1128
The management of coronavirus disease 2019 has become more complex due to the expansion of available therapies. The presence of severe acute respiratory syndrome coronavirus 2 variants and mutations further complicates treatment due to their differin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::168e85568bc8f3b320c51b672c2f1dc4
https://doi.org/10.1093/cid/ciac864
https://doi.org/10.1093/cid/ciac864
Autor:
Jérémie Prévost, Suzanne Pickering, Mitchell J. Mumby, Halima Medjahed, Gabrielle Gendron-Lepage, Gloria G. Delgado, Brennan S. Dirk, Jimmy D. Dikeakos, Christina M. Stürzel, Daniel Sauter, Frank Kirchhoff, Frederic Bibollet-Ruche, Beatrice H. Hahn, Mathieu Dubé, Daniel E. Kaufmann, Stuart J. D. Neil, Andrés Finzi, Jonathan Richard
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT The HIV-1 accessory protein Vpu enhances viral release by counteracting the restriction factor BST-2. Furthermore, Vpu promotes NK cell evasion by downmodulating cell surface NTB-A and PVR, known ligands of the NK cell receptors NTB-A and DN
Externí odkaz:
https://doaj.org/article/a9c7f1cd222240a497b7cabeef046a5f