Výsledky vyhledávání - "Stuart Hwang"

Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer

Autor: Franz von Nussbaum, Ulrich Lücking, Dirk Kosemund, Stuart Ince, Hans Briem, Philip Lienau, Martina Schäfer, Arne Scholz, Ulf Bömer, Dominik Mumberg, Stuart Hwang, Niels Böhnke, Gerhard Siemeister, Karsten Denner, Ildiko Terebesi, Rolf Bohlmann, Raquel Izumi

Publikováno v: Journal of Medicinal Chemistry. 64:11651-11674

Selective inhibition of exclusively transcription-regulating positive transcription elongation factor b/CDK9 is a promising new approach in cancer therapy. Starting from atuveciclib, the first selective CDK9 inhibitor to enter clinical development, l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801ed520b97118562e070f0649f13e62
https://doi.org/10.1021/acs.jmedchem.1c01000

Zobrazit plný text záznamu

Abstract 1859: VIP152, a selective CDK9 inhibitor, demonstrates sensitivity in gynecologic cell lines that are cisplatin sensitive or resistant and delivers in vivo antitumor efficacy

Autor: Melanie M. Frigault, Hermes Garban, Joy M. Greer, Stuart Hwang, Raquel Izumi, Amy J. Johnson, Beatrix Stelte-Ludwig, Ahmed Hamdy

Publikováno v: Cancer Research. 82:1859-1859

Background: The Myc transcription factor has a short half-life of 20-30 minutes (Ramsay et al. 1984) and oncogenic activation and transcriptional addiction leads to sustained levels of Myc, (Gabay et al. 2014). Mechanisms of activation include MYC ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f52e80565ae2a68e0489248b695b364a
https://doi.org/10.1158/1538-7445.am2022-1859

Zobrazit plný text záznamu

VIP152 Is a Novel CDK9 Inhibitor with Efficacy in Chronic Lymphocytic Leukemia

Autor: Steven Sher, Raquel Izumi, Ahmed Hamdy, John C. Byrd, Pearlly S. Yan, Brandi R. Walker, Larry Beaver, Rosa Lapalombella, Amy J. Johnson, Katie Williams, Melanie M. Frigault, Joy M. Greer, James S. Blachly, Alexander Pan, Charles Thomas Gregory, Matthew Purcell, Stuart Hwang, Shelley Orwick

Publikováno v: Blood. 138:270-270

Background: Chronic Lymphocytic Leukemia (CLL) is a genetically heterogeneous disease characterized by clonal expansion of B-lymphocytes that induce secondary immune suppression. CLL is now treated with inhibitors of Bruton tyrosine kinase (BTK) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65e672ee0965ed4ea5b57a45d555a2fd
https://doi.org/10.1182/blood-2021-153812

Zobrazit plný text záznamu

VIP152, a Selective CDK9 Inhibitor, Induces Complete Regression in a High-Grade B-Cell Lymphoma (HGBL) Model and Depletion of Short-Lived Oncogenic Driver Transcripts, MYC and MCL1, with a Once Weekly Schedule

Autor: Raquel Izumi, Harvey Wong, Ahmed Hamdy, Hermes Garban, Amy J. Johnson, Joy M. Greer, Stuart Hwang, Beatrix Stelte-Ludwig, Melanie M. Frigault

Publikováno v: Blood. 138:1192-1192

Background: High-grade B-cell lymphoma (HGBL), previously known as double-hit lymphoma (DHL), is an aggressive type of B-cell non-Hodgkin lymphoma characterized by rearrangements in MYC and BCL2 or BCL6, which drive oncogenic transcription and anti-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29757622de39706ba8772f68b9a589b8
https://doi.org/10.1182/blood-2021-150917

Zobrazit plný text záznamu

PDGF C Is A Selective α Platelet-Derived Growth Factor Receptor Agonist That Is Highly Expressed in Platelet α Granules and Vascular Smooth Muscle

Autor: Bradley J. Stringer, László G. Kömüves, Neill A. Giese, S. Stuart Hwang, David R. Phillips, Paquita Nurden, Shirlee Yonkovich, Nathalie Lokker, Yibing Yan, Li Fang, Sarah Galbraith, Carol M. Sullivan

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 24:787-792

Objective— The platelet-derived growth factor (PDGF) family consists of four members, PDGF A, PDGF B, and 2 new members, PDGF C and PDGF D, which signal through the α and β PDGF receptor (PDGFR) tyrosine kinases. This study was performed to deter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6a945035ceba7096e8366b290cc449
https://doi.org/10.1161/01.atv.0000120785.82268.8b

Zobrazit plný text záznamu

Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells

Autor: Michael Ziman, Stuart Hwang, James E. Tomlinson, Mary E. Gerritsen, Constance Zlot

Publikováno v: British Journal of Pharmacology. 140:595-610

Hepatocyte growth factor (HGF) and vascular endothelial cell growth factor (VEGF) are two potent endothelial mitogens with demonstrated angiogenic activities in animal models of therapeutic angiogenesis. Several recent studies suggest that these grow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0b700751a0c65d0edc3f1471fa4a084
https://doi.org/10.1038/sj.bjp.0705494

Zobrazit plný text záznamu

Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells

Autor: Mary E, Gerritsen, James E, Tomlinson, Constance, Zlot, Michael, Ziman, Stuart, Hwang

Publikováno v: British journal of pharmacology. 140(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c2ceb5ebc956759393e490f18fde067
https://pubmed.ncbi.nlm.nih.gov/14504135

Zobrazit plný text záznamu

In Situ-Synthesized Novel Microarray Optimized for Mouse Stem Cell and Early Developmental Expression Profiling

Autor: Mark G. Carter, Pius M. Brzoska, Naomi T. Ko, Condie E. Carmack, Dawood B. Dudekula, Alexei A. Sharov, Toshio Hamatani, Yong Qian, Minoru S.H. Ko, S. Stuart Hwang, Kazuhiro Aiba

Applications of microarray technologies to mouse embryology/genetics have been limited, due to the nonavailability of microarrays containing large numbers of embryonic genes and the gap between microgram quantities of RNA required by typical microarr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21be7ac3cd92c1c3f384cb1a9b70e535
https://europepmc.org/articles/PMC430900/

Zobrazit plný text záznamu

Anti-AML Activity of Combined Epigenetic Therapy with Novel DNMT1 Inhibitors SGI-110 or SGI-1036 and Histone Deacetylase Inhibitor Panobinostat

Autor: Sanjeev Redkar, Warren Fiskus, Kapil N. Bhalla, Stuart Hwang, Anand Jillella, Rajeshree Joshi, Rekha Rao, Peter Atadja, Pace Johnston, Celalettin Ustun

Publikováno v: Blood. 112:3355-3355

Lysine specific histone methylation and deacetylation and DNA hypermethylation are involved in the epigenetic silencing of tumor suppressor genes (TSG), e.g., p15 and p16. DNA methyltransferase (DNMT) inhibitors 5-azacytidine and 5-aza-2’-deoxycyti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13a9642ddf2d39a76c72b04c4ac0db9e
https://doi.org/10.1182/blood.v112.11.3355.3355

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání