Výsledky vyhledávání - "Stuart Hazeldine"

Bioisosteric Heterocyclic Versions of 7-{[2-(4-Phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: Identification of Highly Potent and Selective Agonists for Dopamine D3 Receptor with Potent in Vivo Activity

Autor: Eldo Kuzhikandathil, Balaram Ghosh, Stuart Hazeldine, Aloke K. Dutta, Swati Biswas, Maarten E. A. Reith, Ingrid Parrington

Publikováno v: Journal of Medicinal Chemistry. 51:3005-3019

In the current report, we extend the SAR study on our hybrid structure 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol further to include heterocyclic bioisosteric analogues. Binding assays were carried out with HE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ac05a908834d97e79cc1a8bcbf07f6
https://doi.org/10.1021/jm701524h

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Further Structural Exploration of Trisubstituted Asymmetric Pyran Derivatives (2S,4R,5R)-2-Benzhydryl-5-benzylamino-tetrahydropyran-4-ol and Their Corresponding Disubstituted (3S,6S) Pyran Derivatives: A Proposed Pharmacophore Model for High-Affinity Interaction with the Dopamine, Serotonin, and Norepinephrine Transporters

Autor: Shijun Zhang, Aloke K. Dutta, Stuart Hazeldine, Jeffrey Deschamps, Fernando Fernandez, Maarten E. A. Reith, Juan Zhen

Publikováno v: Journal of Medicinal Chemistry. 49:4239-4247

In our previous report, we described a novel series of asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their enantiomers as blockers of monoamine transporters in the brain. In this report, we describe the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::064f9994a0478587e39d552321bb8a58
https://doi.org/10.1021/jm0601699

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Transplantable Syngeneic Rodent Tumors: Solid Tumors in Mice

Autor: Thomas H Corbett, Lisa Polin, Bill J Roberts, Alfred J Lawson, Wilbur R Leopold, Kathryn White, Juiwanna Kushner, Jennifer Paluch, Stuart Hazeldine, Richard Moore, James Rake, Jerome P Horwitz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2876c5df954d9b5def332ba4584f5586
https://doi.org/10.1385/1-59259-100-0:041

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Akademický článek

Further StructureâActivity Relationship Studies on 4-((((3S,6S)-6-Benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: Identification of Compounds with Triple Uptake Inhibitory Activity as Potential Antidepressant Agents.

Autor: Bhaskar Gopishetty, Stuart Hazeldine, Soumava Santra, Mark Johnson, Gyan Modi, Solav Ali, Juan Zhen, Maarten Reith, Aloke Dutta

Publikováno v: Journal of Medicinal Chemistry; Apr2011, Vol. 54 Issue 8, p2924-2932, 9p

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Akademický článek

Autor: Swati Biswas, Stuart Hazeldine, Balaram Ghosh, Aloke K. Dutta, Ingrid Parrington, Maarten E. A. Reith, Eldo Kuzhikandathil

Publikováno v: Journal of Medicinal Chemistry; Apr2008, Vol. 51 Issue 10, p3005-3019, 15p

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