Zobrazeno 1 - 10
of 547
pro vyhledávání: '"Stuart H. Ralston"'
Autor:
Jolien Geers, Rong Bing, Tania A. Pawade, Mhairi K. Doris, Marwa Daghem, Alexander J. Fletcher, Audrey C. White, Laura Forsyth, Emily Evans, Jacek Kwieciński, Michelle C. Williams, Edwin J. R. van Beek, Soongu Kwak, Frederique E.C.M. Peeters, Evangelos Tzolos, Piotr J Slomka, Christophe Lucatelli, Stuart H. Ralston, Bernard Prendergast, David E. Newby, Marc R. Dweck
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 18 (2024)
Background Patients with osteoporosis demonstrate increased vascular calcification but the effect of osteoporosis treatments on vascular calcification remains unclear. The present study aimed to examine whether coronary or aortic calcification are in
Externí odkaz:
https://doaj.org/article/4f7a7d04a66b432a8697c04e1d27cc5f
Autor:
Carolina Medina-Gomez, Benjamin H. Mullin, Alessandra Chesi, Vid Prijatelj, John P. Kemp, Chen Shochat-Carvalho, Katerina Trajanoska, Carol Wang, Raimo Joro, Tavia E. Evans, Katharina E. Schraut, Ruifang Li-Gao, Tarunveer S. Ahluwalia, M. Carola Zillikens, Kun Zhu, Dennis O. Mook-Kanamori, Daniel S. Evans, Maria Nethander, Maria J. Knol, Gudmar Thorleifsson, Ivana Prokic, Babette Zemel, Linda Broer, Fiona E. McGuigan, Natasja M. van Schoor, Sjur Reppe, Mikolaj A. Pawlak, Stuart H. Ralston, Nathalie van der Velde, Mattias Lorentzon, Kari Stefansson, Hieab H. H. Adams, Scott G. Wilson, M. Arfan Ikram, John P. Walsh, Timo A. Lakka, Kaare M. Gautvik, James F. Wilson, Eric S. Orwoll, Cornelia M. van Duijn, Klaus Bønnelykke, Andre G. Uitterlinden, Unnur Styrkársdóttir, Kristina E. Akesson, Timothy D. Spector, Jonathan H. Tobias, Claes Ohlsson, Janine F. Felix, Hans Bisgaard, Struan F. A. Grant, J. Brent Richards, David M. Evans, Bram van der Eerden, Jeroen van de Peppel, Cheryl Ackert-Bicknell, David Karasik, Erika Kague, Fernando Rivadeneira
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone biology, particularly to intramembranous ossification, not captured at other skeletal sites. We perform a genome-wide association meta-analy
Externí odkaz:
https://doaj.org/article/48a29b7a20594248bc9b5e7eb32dd872
Autor:
Manisha Korb, Allison Peck, Lindsay N. Alfano, Kenneth I. Berger, Meredith K. James, Nupur Ghoshal, Elise Healzer, Claire Henchcliffe, Shaida Khan, Pradeep P. A. Mammen, Sujata Patel, Gerald Pfeffer, Stuart H. Ralston, Bhaskar Roy, William W. Seeley, Andrea Swenson, Tahseen Mozaffar, Conrad Weihl, Virginia Kimonis, the VCP Standards of Care Working Group
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-15 (2022)
Abstract Valosin-containing protein (VCP) associated multisystem proteinopathy (MSP) is a rare inherited disorder that may result in multisystem involvement of varying phenotypes including inclusion body myopathy, Paget’s disease of bone (PDB), fro
Externí odkaz:
https://doaj.org/article/bf65cfbc490c497cb1d7639887c6cbbe
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Background: Paget’s disease of bone (PDB) is characterized by focal areas of dysregulated bone turnover resulting in increased bone loss and abnormal bone formation with variable severity. PDB has a complex etiology and both genetics and environmen
Externí odkaz:
https://doaj.org/article/d5bb0a6c76fe4c65859aaffb35280f5c
Autor:
Emily M. Rabjohns, Rishi R. Rampersad, Arin Ghosh, Katlyn Hurst, Amanda M. Eudy, Jaime M. Brozowski, Hyun Ho Lee, Yinshi Ren, Anthony Mirando, Justin Gladman, Jessica L. Bowser, Kathryn Berg, Sachin Wani, Stuart H. Ralston, Matthew J. Hilton, Teresa K. Tarrant
Publikováno v:
Cells, Vol 12, Iss 7, p 981 (2023)
Paget’s Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled receptor kin
Externí odkaz:
https://doaj.org/article/d4ebb64765294ed991aa8881105b3d2b
Autor:
Sachin Wani, Anna Daroszewska, Donald M. Salter, Rob J. van ‘t Hof, Stuart H. Ralston, Omar M. E. Albagha
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 4 (2022)
Paget's disease of bone (PDB) is characterized by focal increases in bone remodelling. Genome-wide association studies identified a susceptibility locus for PDB tagged by rs5742915, which is located within the PML gene. Here, we have assessed the can
Externí odkaz:
https://doaj.org/article/00fe2a8aa8354605822d6e6447d01bb6
Autor:
Silvia Marino, Daniëlle de Ridder, Ryan T. Bishop, Nathalie Renema, Marco Ponzetti, Antonia Sophocleous, Mattia Capulli, Abdullah Aljeffery, Giovana Carrasco, Marianela Dalghi Gens, Asim Khogeer, Stuart H. Ralston, Jürg Gertsch, Francois Lamoureux, Dominique Heymann, Nadia Rucci, Aymen I. Idris
Publikováno v:
EBioMedicine, Vol 44, Iss , Pp 452-466 (2019)
Background: Cancer-associated bone disease is a serious complication in bone sarcomas and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is an enzyme of the endocannabinoid system, and is responsible for the degra
Externí odkaz:
https://doaj.org/article/ebe9f63efbf641769fb4ae082d43376f
Publikováno v:
Bone Reports, Vol 14, Iss , Pp 100982- (2021)
Externí odkaz:
https://doaj.org/article/93970a74c7464e46845661da9b9fac61
Autor:
Jonathan H. Tobias, Emma L. Duncan, Erika Kague, Chrissy L. Hammond, Celia L. Gregson, Duncan Bassett, Graham R. Williams, Josine L. Min, Tom R. Gaunt, David Karasik, Claes Ohlsson, Fernando Rivadeneira, James R. Edwards, Fadil M. Hannan, John P. Kemp, Sophie J. Gilbert, Nerea Alonso, Neelam Hassan, Juliet E. Compston, Stuart H. Ralston
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
The discovery that sclerostin is the defective protein underlying the rare heritable bone mass disorder, sclerosteosis, ultimately led to development of anti-sclerostin antibodies as a new treatment for osteoporosis. In the era of large scale GWAS, m
Externí odkaz:
https://doaj.org/article/213a3053bba14147b16d8929aed76dac
Autor:
Antonia Sophocleous, Asim Azfer, Carmen Huesa, Eleni Stylianou, Giovanny Rodriguez Blanco, Stuart H. Ralston
Publikováno v:
Bone Reports, Vol 13, Iss , Pp 100666- (2020)
Externí odkaz:
https://doaj.org/article/02bab160bf6a4a25ab5db7cde4650707