Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Stuart G. Cull-Candy"'
Autor:
Ian D. Coombs, David Soto, Thomas P. McGee, Matthew G. Gold, Mark Farrant, Stuart G. Cull-Candy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
AMPA-type glutamate receptors, which mediate fast excitatory signaling throughout the brain, exhibit profound desensitization, causing a progressive current decline in the continued presence of agonist. Here authors show that homomeric Q/R edited AMP
Externí odkaz:
https://doaj.org/article/a50e120ec8be4c268b59eed05b410716
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1123-1135 (2017)
Summary: Fast excitatory transmission in the CNS is mediated mainly by AMPA-type glutamate receptors (AMPARs) associated with transmembrane AMPAR regulatory proteins (TARPs). At the high glutamate concentrations typically seen during synaptic transmi
Externí odkaz:
https://doaj.org/article/1b016edfb63f49ab918fe04dff457cd5
Autor:
Ondrej Cais, Beatriz Herguedas, Karolina Krol, Stuart G. Cull-Candy, Mark Farrant, Ingo H. Greger
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 728-740 (2014)
AMPA-type glutamate receptors (AMPARs) mediate fast neurotransmission at excitatory synapses. The extent and fidelity of postsynaptic depolarization triggered by AMPAR activation are shaped by AMPAR auxiliary subunits, including the transmembrane AMP
Externí odkaz:
https://doaj.org/article/6a1e1169981048bfbc0552a473bbf56b
Enhanced functional detection of synaptic calcium-permeable AMPA receptors using intracellular NASPM
Autor:
Ian Coombs, Cécile Bats, Craig A Sexton, Dorota Studniarczyk, Stuart G Cull-Candy, Mark Farrant
Publikováno v:
eLife, Vol 12 (2023)
Calcium-permeable AMPA-type glutamate receptors (CP-AMPARs) contribute to many forms of synaptic plasticity and pathology. They can be distinguished from GluA2-containing calcium-impermeable AMPARs by the inward rectification of their currents, which
Externí odkaz:
https://doaj.org/article/49f9a89f7bef4f0c803556abfb71db58
Publikováno v:
Molecular Pharmacology. 101:343-356
AMPA-type gultamate receptors (AMPARs) mediate excitatory signaling in the brain and are therapeutic targets for the treatment of diverse neurological disorders. The receptors interact with a variety of auxiliary subunits, including the transmembrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48668a95fe9b0aac76c01d66d93f78f2
https://doi.org/10.1124/molpharm.121.000473
https://doi.org/10.1124/molpharm.121.000473
Publikováno v:
Biographical Memoirs of Fellows of the Royal Society. 71:423-450
For nearly five decades, Ricardo Miledi was among the foremost researchers in elucidating how nerves transmit signals across synapses. Born in Chihuahua, Mexico, he qualified as a medical doctor, obtained a PhD with Arturo Rosenblueth and then, while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3afc6268ca92838037fc83428dd62372
https://doi.org/10.1098/rsbm.2021.0020
https://doi.org/10.1098/rsbm.2021.0020
Autor:
Ian D. Coombs, Julie Ziobro, Volodymyr Krotov, Taryn‐Leigh Surtees, Stuart G. Cull‐Candy, Mark Farrant
Publikováno v:
EpilepsiaREFERENCES. 63(12)
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors (AMPARs) are ligand-gated cationic channels formed from combinations of GluA1-4 subunits. Pathogenic variants of GRIA1-4 have been described in patients with developmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bebea3fe3f57404473b91f0434ba6d
https://pubmed.ncbi.nlm.nih.gov/36161652
https://pubmed.ncbi.nlm.nih.gov/36161652
Autor:
Stuart G. Cull-Candy, Mark Farrant
Publikováno v:
The Journal of Physiology
AMPA receptors are tetrameric glutamate‐gated ion channels that mediate a majority of fast excitatory neurotransmission in the brain. They exist as calcium‐impermeable (CI‐) and calcium‐permeable (CP‐) subtypes, the latter of which lacks th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6f2d6ac93e98968b1a3bc6a5320bbf
https://doi.org/10.1113/jp279029
https://doi.org/10.1113/jp279029
Calcium-permeable AMPA-type glutamate receptors (CP-AMPARs) contribute to many forms of synaptic plasticity and pathology. They can be distinguished from GluA2-containing calcium-impermeable AMPARs by the inward rectification of their currents, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d378e00a7390147208722bbf036b992
https://doi.org/10.1101/2021.02.18.431828
https://doi.org/10.1101/2021.02.18.431828
