Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Stuart G. Campbell"'
Autor:
Jenette G. Creso, Ilhan Gokhan, Michael J. Rynkiewicz, William Lehman, Jeffrey R. Moore, Stuart G. Campbell
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Dilated cardiomyopathy (DCM) is an inherited disorder often leading to severe heart failure. Linkage studies in affected families have revealed hundreds of different mutations that can cause DCM, with most occurring in genes associated with the cardi
Externí odkaz:
https://doaj.org/article/355e6c5f02564a29bfeacfe09de5bd03
Autor:
Katherine L. Leiby, Yifan Yuan, Ronald Ng, Micha Sam Brickman Raredon, Taylor S. Adams, Pavlina Baevova, Allison M. Greaney, Karen K. Hirschi, Stuart G. Campbell, Naftali Kaminski, Erica L. Herzog, Laura E. Niklason
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract Engineered whole lungs may one day expand therapeutic options for patients with end-stage lung disease. However, the feasibility of ex vivo lung regeneration remains limited by the inability to recapitulate mature, functional alveolar epithe
Externí odkaz:
https://doaj.org/article/343c803588cf4335a13da17cd8eca48c
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 3, Iss , Pp 100025- (2023)
Externí odkaz:
https://doaj.org/article/0b1cb2821fd84341b69ee14b6c6fdc4c
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103208- (2021)
Summary: Paradoxically, many microRNAs appear to exhibit entirely opposite functions when placed in different contexts. For example, miR-125b has been shown to be pro-apoptotic in some studies, but anti-apoptotic in others. To investigate this phenom
Externí odkaz:
https://doaj.org/article/6558ce772050497a963f879c45a2d37f
Autor:
Tyler L. Stevens, Heather R. Manring, Michael J. Wallace, Aaron Argall, Trevor Dew, Peter Papaioannou, Steve Antwi-Boasiako, Xianyao Xu, Stuart G. Campbell, Fadi G. Akar, Maegen A. Borzok, Thomas J. Hund, Peter J. Mohler, Sara N. Koenig, Mona El Refaey
Publikováno v:
Cells, Vol 11, Iss 19, p 3049 (2022)
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by fibro-fatty infiltration with an increased propensity for ventricular arrhythmias and sudden death. Genetic variants in desmosomal genes are associated with ACM. Incomplete
Externí odkaz:
https://doaj.org/article/63890685f8b04fc6b2be5d434329bc0f
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 12 (2021)
Externí odkaz:
https://doaj.org/article/f9193ec5b2a848cfa566e25398772edc
Autor:
Lorenzo R. Sewanan, MS, Jonas Schwan, PhD, Jonathan Kluger, BSE, Jinkyu Park, PhD, Daniel L. Jacoby, MD, Yibing Qyang, PhD, Stuart G. Campbell, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 4, Pp 495-505 (2019)
Summary: Hypertrophic cardiomyopathy (HCM) is often caused by single sarcomeric gene mutations that affect muscle contraction. Pharmacological correction of mutation effects prevents but does not reverse disease in mouse models. Suspecting that disea
Externí odkaz:
https://doaj.org/article/aeb99494d02840d79b8504d6e2152e7a
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Most patients who develop heart failure are unable to elevate their cardiac output on demand due to impaired contractility and/or reduced ventricular filling. Despite decades of research, few effective therapies for heart failure have been developed.
Externí odkaz:
https://doaj.org/article/efec4f4e74c840b19d15c92bedd34fc3
Autor:
Jonas Schwan, Stuart G. Campbell
Publikováno v:
Biomarker Insights, Vol 2015, Iss Suppl. 1, Pp 91-103 (2015)
Externí odkaz:
https://doaj.org/article/28fafd46378f42a0a3445323b44d87bd
Autor:
Jonas Schwan, Stuart G. Campbell
Publikováno v:
Biomarker Insights, Vol 10s1 (2015)
Cardiomyocytes derived from human stem cells are quickly becoming mainstays of cardiac regenerative medicine, in vitro disease modeling, and drug screening. Their suitability for such roles may seem obvious, but assessments of their contractile behav
Externí odkaz:
https://doaj.org/article/1b6bbd3d3c9349efaff0305da930cd8b