Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Stuart G Turville"'
Autor:
KM Rifat Faysal, James C Walsh, Nadine Renner, Chantal L Márquez, Vaibhav B Shah, Andrew J Tuckwell, Michelle P Christie, Michael W Parker, Stuart G Turville, Greg J Towers, Leo C James, David A Jacques, Till Böcking
Publikováno v:
eLife, Vol 13 (2024)
The HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug approved for medical use. Here, we investigate the effect of lenacapavir on HIV capsid stabil
Externí odkaz:
https://doaj.org/article/08ba42401fe84baebde255dedc84b832
Autor:
Pantelis Poumbourios, Christine Langer, Irene Boo, Tasnim Zakir, Rob J Center, Anouschka Akerman, Vanessa Milogiannakis, Anupriya Aggarwal, Bronte A Johnstone, Jungmin Ha, Fasséli Coulibaly, Stuart G Turville, Heidi E Drummer
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1010981 (2023)
The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2 while the S2 subunit mediates virus-cell membrane fusion. S2 is a class I fusion glycoprote
Externí odkaz:
https://doaj.org/article/6d3cf0974e2e42daa96111a1d687d350
Autor:
Fiona Tea, Alberto Ospina Stella, Anupriya Aggarwal, David Ross Darley, Deepti Pilli, Daniele Vitale, Vera Merheb, Fiona X Z Lee, Philip Cunningham, Gregory J Walker, Christina Fichter, David A Brown, William D Rawlinson, Sonia R Isaacs, Vennila Mathivanan, Markus Hoffmann, Stefan Pöhlman, Ohan Mazigi, Daniel Christ, Dominic E Dwyer, Rebecca J Rockett, Vitali Sintchenko, Veronica C Hoad, David O Irving, Gregory J Dore, Iain B Gosbell, Anthony D Kelleher, Gail V Matthews, Fabienne Brilot, Stuart G Turville
Publikováno v:
PLoS Medicine, Vol 18, Iss 7, p e1003656 (2021)
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antibody neutralization response and its evasion by emerging viral variants and variant of concern (VOC) are unknown, but critical to understand reinfection risk and breakthrough infect
Externí odkaz:
https://doaj.org/article/9d1dac9be74d4ec29e5d0a3a9bd84bf7
Autor:
Samantha A McAllery, Chantelle L Ahlenstiel, Kazuo Suzuki, Geoff P Symonds, Anthony D Kelleher, Stuart G Turville
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
While current antiretroviral therapy has significantly improved, challenges still remain in life-long targeting of HIV-1 reservoirs. Lentiviral gene therapy has the potential to deliver protective genes into the HIV-1 reservoir. However, inefficient
Externí odkaz:
https://doaj.org/article/13bb28f649e7422586405c6b47543506
Autor:
Lachlan R Gray, Stuart G Turville, Tina L Hitchen, Wan-Jung Cheng, Anne M Ellett, Hamid Salimi, Michael J Roche, Steve L Wesselingh, Paul R Gorry, Melissa J Churchill
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90620 (2014)
Astrocytes are extensively infected with HIV-1 in vivo and play a significant role in the development of HIV-1-associated neurocognitive disorders. Despite their extensive infection, little is known about how astrocytes become infected, since they la
Externí odkaz:
https://doaj.org/article/8eba2162e2f944e3b4f5387b7505d61f
Autor:
Sarah K Mercier, Heather Donaghy, Rachel A Botting, Stuart G Turville, Andrew N Harman, Najla Nasr, Hong Ji, Ulrike Kusebauch, Luis Mendoza, David Shteynberg, Kerrie Sandgren, Richard J Simpson, Robert L Moritz, Anthony L Cunningham
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003700 (2013)
HIV-1 is taken up by immature monocyte derived dendritic cells (iMDDCs) into tetraspanin rich caves from which the virus can either be transferred to T lymphocytes or enter into endosomes resulting in degradation. HIV-1 binding and fusion with the DC
Externí odkaz:
https://doaj.org/article/b648816bfe1347eea9fbd8993249f6ff
The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes.
Autor:
Lachlan R Gray, Gilda Tachedjian, Anne M Ellett, Michael J Roche, Wan-Jung Cheng, Gilles J Guillemin, Bruce J Brew, Stuart G Turville, Steve L Wesselingh, Paul R Gorry, Melissa J Churchill
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62196 (2013)
HIV-1 establishes infection in astrocytes and macroage-lineage cells of the central nervous system (CNS). Certain antiretroviral drugs (ARVs) can penetrate the CNS, and are therefore often used in neurologically active combined antiretroviral therapy
Externí odkaz:
https://doaj.org/article/d97c6377d27544618061aac3fbdc631d
Autor:
Anupriya Aggarwal, Tina L Iemma, Ivy Shih, Timothy P Newsome, Samantha McAllery, Anthony L Cunningham, Stuart G Turville
Publikováno v:
PLoS Pathogens, Vol 8, Iss 6, p e1002762 (2012)
Paramount to the success of persistent viral infection is the ability of viruses to navigate hostile environments en route to future targets. In response to such obstacles, many viruses have developed the ability of establishing actin rich-membrane b
Externí odkaz:
https://doaj.org/article/5a0c17ebecea4f0d8243b1dff02bda93
Autor:
Stuart G Turville, Meropi Aravantinou, Todd Miller, Jessica Kenney, Aaron Teitelbaum, Lieyu Hu, Anne Chudolij, Tom M Zydowsky, Michael Piatak, Julian W Bess, Jeffrey D Lifson, James Blanchard, Agegnehu Gettie, Melissa Robbiani
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3162 (2008)
Anti-HIV microbicides are being investigated in clinical trials and understanding how promising strategies work, coincident with demonstrating efficacy in vivo, is central to advancing new generation microbicides. We evaluated Carraguard and a new ge
Externí odkaz:
https://doaj.org/article/b2e0ec5a9dda40b193d8963381ddb073
Autor:
Andreas Schweizer, Peter Rusert, Livia Berlinger, Claudia R Ruprecht, Axel Mann, Stéphanie Corthésy, Stuart G Turville, Meropi Aravantinou, Marek Fischer, Melissa Robbiani, Patrick Amstutz, Alexandra Trkola
Publikováno v:
PLoS Pathogens, Vol 4, Iss 7, p e1000109 (2008)
Here, we describe the generation of a novel type of HIV entry inhibitor using the recently developed Designed Ankyrin Repeat Protein (DARPin) technology. DARPin proteins specific for human CD4 were selected from a DARPin DNA library using ribosome di
Externí odkaz:
https://doaj.org/article/63f2e46f9bed439bb295b004f6d2249c