Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Stuart Ellison"'
Systemic immune challenge exacerbates neurodegeneration in a model of neurological lysosomal disease
Autor:
Oriana Mandolfo, Helen Parker, Èlia Aguado, Yuko Ishikawa Learmonth, Ai Yin Liao, Claire O’Leary, Stuart Ellison, Gabriella Forte, Jessica Taylor, Shaun Wood, Rachel Searle, Rebecca J Holley, Hervé Boutin, Brian W Bigger
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1579-1602 (2024)
Abstract Mucopolysaccharidosis type IIIA (MPS IIIA) is a rare paediatric lysosomal storage disorder, caused by the progressive accumulation of heparan sulphate, resulting in neurocognitive decline and behavioural abnormalities. Anecdotal reports from
Externí odkaz:
https://doaj.org/article/6b33c2341e654421a1e1e4301ad75310
Autor:
Stuart Ellison, Karen Buckland, Yuko Learmonth, Victoria Day, Spandan Kalra, Lauren Howe, Francisco José Roman-Rodriguez, Jose Bonafont, Laura Booth, Rebecca Holley, Jon Smythe, Simon Jones, Adrian Thrasher, Claire Booth, Brian W. Bigger
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101271- (2024)
Hematopoietic stem cell gene therapy (HSCGT) is a promising therapeutic strategy for the treatment of neurodegenerative, metabolic disorders. The approach involves the ex vivo introduction of a missing gene into patients’ own stem cells via lentivi
Externí odkaz:
https://doaj.org/article/c6d56cc1cb214a2393e79a6e7acc9046
Autor:
Stuart Ellison, Aiyin Liao, Hélène F.E. Gleitz, Helen Parker, Laura Booth, John Robinson, Shaun Wood, Jessica Taylor, Rebecca Holley, Brian W. Bigger
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101127- (2023)
Mucopolysaccharidosis type II (MPSII) is a pediatric lysosomal storage disease caused by deficiencies in the IDS (iduronate-2-sulfatase) gene resulting in accumulation of glycosaminoglycans, multisystem disease, and profound neurodegeneration in seve
Externí odkaz:
https://doaj.org/article/9b7c441d02a944129089fa20c2a74363
Autor:
Shaun Roger Wood, Ahsan Chaudrhy, Stuart Ellison, Rachel Searle, Constance Burgod, Ghazala Tehseen, Gabriella Forte, Claire O'Leary, Helene F Gleitz, Aiyin Liao, James Cook, Rebecca Jane Holley, Brian Bigger
Mucopolysaccharidosis type II (MPSII) is a lysosomal storage disease caused by a mutation in the IDS gene, resulting in deficiency of the enzyme iduronate-2-sulfatase (IDS) causing heparan sulfate (HS) and dermatan sulfate (DS) accumulation in all ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde2ec6ef8b048fb8cd4a96350c9ba4e
http://hdl.handle.net/10044/1/104683
http://hdl.handle.net/10044/1/104683
Autor:
Robert F Wynn, Jane L Kinsella, Rebecca J Holley, Jane Potter, Adrian J. Thrasher, Claire Booth, Karen Buckland, Natalia Izotova, Stewart Rust, Daniel Weisberg, Heather J Church, Karen L Tylee, Kathryn L Brammeier, Helena Lee, Laura Ford, Atusa Sadegholnejat, Simon A Jones, Stuart Ellison, Brian Bigger
Publikováno v:
Blood. 140:1897-1898
Autor:
Simon A. Jones, Jane L. Kinsella, Jane Potter, Adrian Thrasher, Claire Booth, Karen Buckland, Natalia Izotova, Stewart Rust, Daniel Weisberg, Heather Church, Karen Tylee, Helena Lee, Laura Ford, Rebecca J. Holley, Stuart Ellison, Brian W. Bigger, Robert F. Wynn
Publikováno v:
Molecular Genetics and Metabolism. 135:S63-S64
Autor:
Claire Horgan, Simon Jones, Rebecca Holley, Laura Booth, April Hoyle, Stuart Ellison, Brian Bigger, Robert Wynn
Publikováno v:
Molecular Genetics and Metabolism. 135:S57
Autor:
David Carpentier, Kristis Vevis, Antonio Trabalza, Christos Georgiadis, Stuart Ellison, Rowan Asfahani & Nicholas D Mazarakis
Publikováno v:
Human Gene Therapy.
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 8(7)
SUMMARY BACKGROUND: We have previously shown that the receptor-like protein tyrosine phosphatase (PTP) CD148 is essential for initiating glycoprotein VI (GPVI) signaling in platelets. We proposed that CD148 does so by dephosphorylating the C-terminal
Autor:
Jenson Lim, Steve G. Thomas, Tarvinder S. Dhanjal, Jocelyn M. Auger, Alexandra Mazharian, Arthur Weiss, Steve P. Watson, Stuart Ellison, Yotis A. Senis, Kristin N. Kornerup, Jing W. Zhu, Yan Zhao, Neena Kalia, Michael G. Tomlinson
Publikováno v:
Blood
Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in pathologic conditions resulting from blocked blood vessels, including myocardial infarction and ischemic stroke. Platelet adhesion, activation, and aggregation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54445e558843f8b894e4293dfb75d993
http://eprints.bham.ac.uk/253/
http://eprints.bham.ac.uk/253/