Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Stuart D. Greenhill"'
Autor:
Anderson Brito da Silva, Jane Pennifold, Ben Henley, Koustav Chatterjee, David Bateman, Roger W. Whittaker, Abhijit Joshi, Hrishikesh Kumar, Claire Nicholson, Mark R. Baker, Stuart D. Greenhill, Richard Walsh, Stefano Seri, Roland S. G. Jones, Gavin L. Woodhall, Mark O. Cunningham
Publikováno v:
Epilepsia Open, Vol 7, Iss 3, Pp 488-495 (2022)
Abstract Focal cortical dysplasia (FCD) is one of the most common malformations causing refractory epilepsy. Dysregulation of glutamatergic systems plays a critical role in the hyperexcitability of dysplastic neurons in FCD lesions. The pharmacoresis
Externí odkaz:
https://doaj.org/article/4f75c11420504a2b92f84ffdac58cc0c
Autor:
Sukhvir K. Wright, Richard E. Rosch, Max A. Wilson, Manoj A. Upadhya, Divya R. Dhangar, Charlie Clarke-Bland, Tamara T. Wahid, Sumanta Barman, Norbert Goebels, Jakob Kreye, Harald Prüss, Leslie Jacobson, Danielle S. Bassett, Angela Vincent, Stuart D. Greenhill, Gavin L. Woodhall
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Sukhvir Wright et al. present a NMDAR antibody-induced model of encephalitis in rats and use in vitro, in vivo, and in silico electrophysiology to examine alterations in neural circuit behavior. Their results suggest that reduction of NMDARs leads to
Externí odkaz:
https://doaj.org/article/044abfeed3bf450a87ab1e4b273bc087
Autor:
Sukhvir K. Wright, Max A. Wilson, Richard Walsh, William B. Lo, Nilesh Mundil, Shakti Agrawal, Sunny Philip, Stefano Seri, Stuart D. Greenhill, Gavin L. Woodhall
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 6, Pp 883-890 (2020)
Abstract Objective The amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) is increasingly recognized as a therapeutic target in drug‐refractory pediatric epilepsy. Perampanel (PER) is a non‐competitive AMPAR antagonis
Externí odkaz:
https://doaj.org/article/669feefa2ed045789242148cb5a471e8
Autor:
Alan D. Goddard, Stuart D. Greenhill, Alice J. Rothnie, James Heritage, Lucy Holder, Joanne R. Gough
Publikováno v:
Business Teaching Beyond Silos ISBN: 9781802209037
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3503bdd20fd3f98bde5b98bd04a4348c
https://doi.org/10.4337/9781802209037.00010
https://doi.org/10.4337/9781802209037.00010
Autor:
Andrea Markou, Lucas Unger, Mohammed Abir-Awan, Ahmed Saadallah, Andrea Halsey, Zita Balklava, Matthew Conner, Susanna Törnroth-Horsefield, Stuart D. Greenhill, Alex Conner, Roslyn M. Bill, Mootaz M. Salman, Philip Kitchen
The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the movement of water across biological membrane by osmosis, as well as facilitating the diffusion of small polar solutes. AQPs have been recognised as drug targets for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6225e190153f210863c0e8be13b43d06
https://publications.aston.ac.uk/id/eprint/43431/1/1_s2.0_S0005273621003011_main.pdf
https://publications.aston.ac.uk/id/eprint/43431/1/1_s2.0_S0005273621003011_main.pdf
Autor:
Sunny Philip, Shakti Agrawal, Stuart D. Greenhill, Sukhvir Wright, William B. Lo, Richard A. Walsh, Nilesh Mundil, Max A Wilson, Gavin L. Woodhall, Stefano Seri
Publikováno v:
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology, Vol 7, Iss 6, Pp 883-890 (2020)
Annals of Clinical and Translational Neurology, Vol 7, Iss 6, Pp 883-890 (2020)
Objective The amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) is increasingly recognized as a therapeutic target in drug‐refractory pediatric epilepsy. Perampanel (PER) is a non‐competitive AMPAR antagonist, and pr
Autor:
Claire Nicholson, Hrishikesh Kumar, Gavin L. Woodhall, Richard A. Walsh, Roger W. Whittaker, Stuart D. Greenhill, Abhijit Joshi, Mark O. Cunningham, Anderson Brito da Silva, Jane Pennifold, Ben Henley, Koustav Chatterjee, David Bateman, Mark R. Baker, Stefano Seri, Roland S.G. Jones
Publikováno v:
Epilepsia open. 7(3)
Focal cortical dysplasia (FCD) is one of the most common malformations causing refractory epilepsy. Dysregulation of glutamatergic systems plays a critical role in the hyperexcitability of dysplastic neurons in FCD lesions. The pharmacoresistant natu
Autor:
Harald Prüss, Angela Vincent, Manoj A. Upadhya, Stuart D. Greenhill, Sumanta Barman, Tamara T Wahid, Jakob Kreye, Charlie Clarke-Bland, Richard E. Rosch, Danielle S. Bassett, Norbert Goebels, Max A Wilson, Leslie Jacobson, Divya R Dhangar, Gavin L. Woodhall, Sukhvir Wright
Publikováno v:
Communications Biology
Communications biology 4(1), 1106 (2021). doi:10.1038/s42003-021-02635-8
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Communications biology 4(1), 1106 (2021). doi:10.1038/s42003-021-02635-8
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Seizures are a prominent feature in N-Methyl-D-Aspartate receptor antibody (NMDAR antibody) encephalitis, a distinct neuro-immunological disorder in which specific human autoantibodies bind and crosslink the surface of NMDAR proteins thereby causing
Autor:
Craig C. Garner, Angela M. Kaindl, Sukhvir Wright, Paul Turko, Imre Vida, Jonathan Wickel, A. van Casteren, H. Pruess, L. Stoeffler, M. Nikolaus, M.-L. Machule, Max A Wilson, Christian Geis, S. van Hoof, Stuart D. Greenhill, Masaki Fukata, Jakob Kreye, Yuko Fukata, Elisa Sanchez-Sendin, Hans-Christian Kornau, S. M. Reincke, Gavin L. Woodhall
Autoantibodies targeting the GABAA receptor (GABAAR) hallmark an autoimmune encephalitis presenting with frequent seizures and psychomotor abnormalities. Their pathogenic role is still not well-defined, given the common overlap with further autoantib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c623f9c08956048ce2e9777d1dc0fe1
https://doi.org/10.1101/2021.01.28.428602
https://doi.org/10.1101/2021.01.28.428602
Autor:
Stuart D. Greenhill, Divya R Dhangar, Charlie Clarke-Bland, Norbert Goebels, Richard E. Rosch, Gavin L. Woodhall, Danielle S. Bassett, Max A Wilson, Jakob Kreye, Leslie Jacobson, Angela Vincent, Sumanta Barman, Harald Prüss, Manoj A. Upadhya, Tamara T Wahid, Sukhvir Wright
Seizures are a prominent feature in N-Methyl-D-Aspartate receptor antibody (NMDAR-Ab) encephalitis, a distinct neuro-immunological disorder in which specific human autoantibodies bind and crosslink the surface of NMDAR proteins thereby causing intern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48bd33c685913d58f5ce38768d21fda3
https://doi.org/10.1101/2020.12.22.423962
https://doi.org/10.1101/2020.12.22.423962